DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema3b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001073411.1	Gene:	Sema3b / 363142	RGDID:	1310079	Length:	749	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	220/788 - (27%)
Similarity:	337/788 - (42%)	Gaps:	147/788 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVP 161
            ||.::...|.:||.|.|.:||:.::.:: ::|.|.:|.:..:.|...||| ...|.|:::::...
  Rat    59 LVDEERGRLFVGAENHVASLSLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAY 123

  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDS------NYTLEATKNGQAVCPYDPRHNSTSVLADNELYSG 220
            :...|..|||.:|.|.|....:...      ...|...::|:...||||||.:.|||...|||||
  Rat   124 NHTHLLACGTGAFHPTCAFVEVGHRLEEPMLRLDLRKLEDGKGKSPYDPRHRAASVLVGEELYSG 188

  Fly   221 TVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETAVEF 273
            ..||..|.|..|:|.     .|:||.:||..||.|.||..|       ...|.:||||||:|||.
  Rat   189 VAADLMGRDFTIFRSLGQNPSLRTEPHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFRESAVEA 253

  Fly   274 INC-GKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-DYPFYFNEIQSASNLVEGQY 336
            ... |:...|||.::|:.|.||.....|:||:|||:||.||:|| :...:|:::|....|
  Rat   254 APAMGRMTVSRVGQICRNDLGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLL----- 313

  Fly   337 GSMSSK-----LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
               ||:     .:|.||:|.|....|||||.:::.|:...|.|.|..:.|....|:.. ..:||.
  Rat   314 ---SSRDRQTPFLYAVFSTSSGIFQGSAVCVYSMNDVRRAFLGPFAHKEGPTHQWVSY-QGRVPY 374

  Fly   397 PRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQI 454
            ||||.|       .:.::..||..:.|.:.|.||..:|.....:|:.::....|.|||||.|...
  Rat   375 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPMGGRPLFLQVGAGYTFTQIAADRVA 439

  Fly   455 KTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQ 519
            ...|  .|||:|:|||.|.::|.::.... |......:::||:.|...|..|.:::|
  Rat   440 AADG--HYDVLFIGTDVGTVLKVISVPKG-SRPNSEGLLLEELQVFEDSAAITSMQI-------- 493

  Fly   520 PKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLE 584
                |....:|.|.:.|.|..|.|||| .....:|:||...:|||||||   |...:...|. .:
  Rat   494 ----SSKRHQLYIASPSAVAQIALHRC-PALGRACAECCLARDPYCAWD---GSACTRFQPT-AK 549

  Fly   585 ENYFYQNVATGQHAA-C---PSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFE 645
            ..:..|::..|..:. |   ||..:..:....|.::|        .:..:.:.:.:..:::..|.
  Rat   550 RRFRRQDIRNGNPSTLCSGDPSHSVLLERKVLGVERG--------SAFLECEPRSLQAHVEWTFH 606

  Fly   646 GPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQ- 709
            .   :.:..:.|...|..|.....|   .||.|.       ||    :|..:.......:.|.|
  Rat   607 R---AGEAAHTQVLAEERVERTARG---LLLRGL-------RR----QDSGVYLCVAVEQGFSQP 654

  Fly   710 -RQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNS 773
             |:.|....|:.          |.|.:..||...:|.||.|...:.....|.:|   ....|.||
  Rat   655 LRRLVLHVLSAA----------QAERLARAEEAAVPAPPGPKLWYRDFLQLVEP---GGGGGANS 706

  Fly   774 ETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLG-- 836
            ..:.:.||.                  .|.|..|:.|:|                  |||.:.
  Rat   707 LRMCRPQPG------------------PHSVAADSRRKG------------------RNRRMHVS 735

  Fly   837 --RARRQP 842
              ||.|.|
  Rat   736 ELRAERGP 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	156/480 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
Sema3b	NP_001073411.1	Sema	46..516	CDD:301699	156/480 (33%)
		PSI	515..>551	CDD:214655	14/40 (35%)
		Ig	575..665	CDD:299845	17/114 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920