DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema4g

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001101996.1	Gene:	Sema4g / 361764	RGDID:	1310436	Length:	837	Species:	Rattus norvegicus

Alignment Length:	865	Identity:	214/865 - (24%)
Similarity:	336/865 - (38%)	Gaps:	226/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK---------LV 100
            :|..|..:|..||...:...|.    .||...::..|...:.: ...|.:.|||         |:
  Rat     2 WGRLWPLLFSFLTATAVPGPSL----RRPSRELDATPRMTISY-EELSWIRHFKGQAQNYSTLLL 61

  Fly   101 TKDGNSLLIGARNTVFNLSIHDLVE--QQRLVW-TSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            .:....||:|||..:|:||..|:.:  .:.:.| .|||..:| |..|||:.:. |.|::|.:...
  Rat    62 EEASQRLLVGARGALFSLSARDIGDGTHKEIHWEASPEMQSK-CHQKGKNNQTECFNHVRFLQRL 125

  Fly   162 SPGRLFVCGTNSFRPMC-----NTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGT 221
            :....:.|||::|:|:|     ..:|:..|      .:.|:..|||||....|.::.|..||:.|
  Rat   126 NASHFYACGTHAFQPLCAAIDAEAFILPTS------FEEGKEKCPYDPARGFTGLIIDGGLYTAT 184

  Fly   222 VADFSGSDPIIYR----EPLQTEQYDSLSLNAPNFVSSFT----------QGDFVYFFF--RETA 270
            ..:|. |.|.|.|    ..|:||:.....||...||.|..          ..|.:|:||  ||..
  Rat   185 RYEFR-SIPDIRRSRHPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSVVGDDDKIYYFFMEREEG 248

  Fly   271 VEFINCGKAIY--SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVE 333
            .......::.:  :|||||||.|.||....:.:||||||:||.|.||     .:..::...:|
  Rat   249 SSSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSL-- 306

  Fly   334 GQYGSMSSKLIYGVF--NTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
             ...:.|....|.||  .|...::..||:|.:.|.:|...|.|.|.|.......|...... ||:
  Rat   307 -DADTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRWGRYEGG-VPE 369

  Fly   397 PRPGSC---------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDA 452
            ||||||         :|.|:.||...|:|:|.|.||...|.....:|:|::.:.  |:|.: ...
  Rat   370 PRPGSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNV--RYTHL-TGT 431

  Fly   453 QIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQY 517
            .:..|.|.|||::|:||..|.|.|:|...|.       ..:||||.|..:|:.:.|| ::..||:
  Rat   432 HVSIPAGPTYDLLFLGTADGWIHKAVVLGSG-------MHIIEEIQVFRESQSVDNL-VISPMQH 488

  Fly   518 DQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-------- 574
                       .|.:...|.|:...|..|  .:..||.:|:..:||||.||.....|
  Rat   489 -----------SLYVGAASGVIQFPLSSC--SRYRSCYDCILARDPYCGWDSSTHACMVATTIAN 540

  Fly   575 ------------------RSHGAPRWLEENYFYQNVATGQHAACPSGK----------INSKDAN 611
                              |..|.|    ..:..::|..|.....|..:          :|...:.
  Rat   541 RTALIQDIERGNRGCEGSRDAGPP----PPFKTRSVLRGDDVLLPCDQPSNLARALWLLNGSKSL 601

  Fly   612 AGEQKGFRNDMD---LLDSRRQSK-------DQEIIDNIDKNFE------------------GPQ 648
            :..|.|:|..:|   :.|::.:..       ::..:..:..::.                  |.|
  Rat   602 SDGQDGYRVGVDGLLVTDTQLEHSGNYGCYAEENGLRMLLASYSLIVRPATPAPAPQAPATPGAQ 666

  Fly   649 ISADIINAQYTVETLVMA----VLAGSIFSLLVGFFTGYFCGRR--------------------- 688
            ::.| :...|.|...::.    :||.|:  |.|....|...|||
  Rat   667 LAHD-MRLFYVVAIAILGGLCLILASSL--LYVACLRGGRRGRRRKYSLGRAGRAGGSAVQLQTV 728

  Fly   689 ---CHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750
               |..:|||.           :..:...|..|.|.     :::|       .|....|.||||
  Rat   729 SGQCPGEEDDG-----------DDGEGAGSLESGCL-----QIIP-------GEGAPAPPPPPP- 769

  Fly   751 KMHSPKNTLRKPPMHQMHQG 770
                      .||..::..|
  Rat   770 ----------PPPPAELTNG 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	151/501 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/59 (20%)
Sema4g	NP_001101996.1	Sema	47..504	CDD:301699	149/495 (30%)
		PSI	505..>533	CDD:279745	10/29 (34%)
		Ig_Sema4B_like	565..648	CDD:143280	9/82 (11%)
		IG_like	571..648	CDD:214653	9/76 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910