Protein Alignment Sema1a and Sema6a

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_003751830.1
• Gene: Sema6a / 361324
• RGDID: 1305493
• Length: 1048
• Species: Rattus norvegicus
• Alignment Length: 1140
• Identity: 298/1140 - (26%)
• Similarity: 453/1140 - (39%)
• Gaps: 379/1140 - (33%)

  Fly    13 SASNSNYNKGHKMHLKSATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYV 77
            |.|:.||.|.:.:.:.....:.|..:|:|.       :|:.:::
  Rat    28 SISHGNYTKQYPVFVGHKPGRNTTQRHRLD-------IQMIMIM--------------------- 64

  Fly    78 ELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSI-----HDLVEQQRLVWTSPEDD 137
                                      ..:|.|.||:.::.:.|     .::...::|.|.|.:.|
  Rat    65 --------------------------NRTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQAD 103

  Fly   138 TKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPY 202
            ...|.:|||.::.|.|:|::::..:...|||||||:|.|.|..|.: |:..|.....:|.|.|||
  Rat   104 VDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRV-DTLETFGDEFSGMARCPY 167

  Fly   203 DPRHNSTSVLADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFV 262
            |.:|.:.::.||.:|||.||.||...|.:|||.     .|:|.::||..|..|.||.:...||::
  Rat   168 DAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFVQAVDYGDYI 232

  Fly   263 YFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQ 326
            ||||||.|||:...||.::.|||:|||.|.||..| ...:||||||:|||||:|||..||||.:|
  Rat   233 YFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQ 297

  Fly   327 SASNL--VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPV 389
            :.:::  :.|:      .::...|:||.||||||||||:.:.|||:.|.|:||||...:|.|.||
  Rat   298 AVTDVIRINGR------DVVLATFSTPYNSIPGSAVCAYDMLDIANVFTGRFKEQKSPDSTWTPV 356

  Fly   390 NNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFT 446
            .:.:||.||||.|        :..|...||.||||||||.||||.||:..::|..:||...||.|
  Rat   357 PDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYRLT 421

  Fly   447 QIAVDAQIKTPGG-KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLE 510
            :||||   .|.|. :.:.|:|:|::.|.|:|.: |....|.....|:.:||::|.
  Rat   422 KIAVD---NTAGPYENHTVVFLGSEKGIILKFL-ARIGSSGFLNGSLFLEEMNVY---------- 472

  Fly   511 IVRTMQYDQPKDGSYD---------------DGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVA 559
                    .|:..|||               .|.|.:...:.|:.:.|.||  ::...|.: |:|
  Rat   473 --------NPEKCSYDGVEDKRIMGMQLDKASGSLYVAFSTCVIKVPLGRC--ERHGKCKKTCIA 527

  Fly   560 LQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ---------------------------- 596
            .:||||.|.|..|.| :|.:|  |....|.|::..|.
  Rat   528 SRDPYCGWVKETGSC-AHLSP--LSRLAFEQDIERGNTDGLGDCHNSFVALNDISTPLPDYEMSF 589

  Fly   597 -------HAACPSGKINSKDANAG--EQKGFRNDMDLLDS-------------RRQSKDQEIIDN 639
                   .:..||...:...:..|  .|.|..:..|||.:             ..|.|...|.::
  Rat   590 NTVYGRASSLYPSTTTSDSASRDGHESQGGMLDWNDLLKAPGNTDPLGAVSSHNHQDKKGVIRES 654

  Fly   640 IDKNFEGPQISADIINAQYTVETL-----VMAVLAGSIFSLLVGF-------------------- 679
            ..|:           |.|....||     ::|.:.|::||.::.:
  Rat   655 YLKS-----------NDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVAVVQRKEKEL 708

  Fly   680 -------------FTGYFCGRRCHKDEDDN----------------------------------L 697
                         .:|.| |....||....                                  |
  Rat   709 THSRRGSMSSVTKLSGLF-GDSQSKDPKPEAILTPLMHNGKLATPSNTAKMLIKADQHHLDLTAL 772

  Fly   698 PYPDTE------------YEYFEQRQN-VNS------------FPSSCRIQQEPKLLPQVEEVTY 737
            |.|::.            ...:|:.|| :|:            .|:...::..|..:|.|
  Rat   773 PTPESTPTLQQKRKPNRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSV----- 832

  Fly   738 AEPVLLP------------QPPPPN-------------------KMH----SPKNTLR------- 760
               |:||            ||....                   |.|    ||.:.:.
  Rat   833 ---VVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDS 894

  Fly   761 ---KPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFG-----------TLRSHQVMGDNYRR 811
               |.|..:...||...:|.|   .|.:.:...:...::|           ..||||
  Rat   895 LPPKVPQREASLGPTGASLSQ---TGLSKRLEMQHSSSYGLEYKRSYPTNSLTRSHQ-------- 948

  Fly   812 GDGFSTTRSVKKAVNNTN-------TRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQ---SQQP 866
                :||  :|:  ||||       :||:||||....||....|...:.:|||...|.   |:||
  Rat   949 ----ATT--LKR--NNTNSSNSSHLSRNQSLGRGDNPPPAPQRVDSIQVHSPQPSGQAVTVSRQP 1005

  Fly   867 HSSSGSSPVMSNSSSSPA-PPSSSPSPQESPKNCS 900
            ..::.:|...|....:|: .|...|.|..:|.:.|
  Rat  1006 SLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTS 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	182/491 (37%)
		PSI	545..>579	CDD:214655	14/34 (41%)
Sema6a	XP_003751830.1	Sema_6A	48..513	CDD:200527	185/547 (34%)
		PSI	514..>544	CDD:396154	13/32 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.960