DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema6d

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_038960912.1	Gene:	Sema6d / 311384	RGDID:	1310910	Length:	1086	Species:	Rattus norvegicus

Alignment Length:	1112	Identity:	331/1112 - (29%)
Similarity:	477/1112 - (42%)	Gaps:	248/1112 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GNESVVDH---FKLVTKDGNSLLIGARNTVFNLSIHDL-----VEQQRLVWTSPEDDTKMCLVKG 145
            ||||  .|   |:|:.|..::|.|..|:.|:.::::|:     :..::|.|.|.:.|.:.|.:||
  Rat    50 GNES--QHRLDFQLMLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKG 112

  Fly   146 KDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTS 210
            |.::.|.|:|::.|..:...:||||||:|.|||..|.:|...|..|.. :|.|.||:|.|..:.:
  Rat   113 KHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI-SGLARCPFDARQTNVA 176

  Fly   211 VLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETA 270
            :.||.:|||.|||||..||.:|||     ..|:|.:|||..:..|:|:.:...|::|||||||.|
  Rat   177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIA 241

  Fly   271 VEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG 334
            ||..|.|||:||||||:||.|.||..| ....||||||:|||||:|||..|||:.:||.::::
  Rat   242 VEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDII-- 304

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
            |...:.:  :.|||.|..|||||||||||::.||...|:|:||||...:|.|..|...|||.|||
  Rat   305 QINGIPT--VIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

  Fly   400 GSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |.|        :..|...||.||:|||:|.|||..||....:|...:|...||.|.|.||   ::
  Rat   368 GCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVD---RS 429

  Fly   457 PGG-KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVL------TKSEPIRNLEIVRT 514
            .|. :.|.|||||::.|.::|.:...|..|.:  .||::|||:..      .:||..|.   |.:
  Rat   430 AGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLN--DSVLLEEIEAYNPAKCSAESEEDRK---VVS 489

  Fly   515 MQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCAWDKIAGKC---- 574
            :|.|:      |...|.:...|.||.|.|.||  ::..||.: |:|.:||||.| ...|.|
  Rat   490 LQLDR------DHHALYVAFSSCVVRIPLSRC--ERYGSCKKSCIASRDPYCGW-LSQGVCERVT 545

  Fly   575 -------------RSHGAPRWLEENYFYQNVA-TGQ-HAACP----------------------- 601
                         .:|.|..: |::..|.|.| .|. |.:.|
  Rat   546 LGMLLLTEDFFAFHNHSAGGY-EQDTEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSSS 609

  Fly   602 ------SGKINSKDANAGEQKGFRNDMDLLDSRR--------QSKDQEIIDNIDKNFEGPQISAD 652
                  |.:|.||..:....|       |..||:        .|...:.|..|.|.......|.|
  Rat   610 VTTVASSPEITSKVIDTWRPK-------LTSSRKFVVQDDPNTSDFTDTISGIPKGVRWEVQSGD 667

  Fly   653 IINAQYTVETLVMAVLAGSIFSLLVGFFTG--YFC--------GRRCHKDEDDNLPYPDTEYEYF 707
             .|....:..|:..|.|..:   |..|..|  .:|        .|:.|||.:......|:...:.
  Rat   668 -SNQMVHMNVLITCVFAAFV---LGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFA 728

  Fly   708 -----------EQRQNV------------------NSFPSSCRIQ---QEPKL--LPQVEEVTYA 738
                       |.:||:                  |:.|.|..:.   |.|:|  ||..|    :
  Rat   729 KLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNTDPKSMAMDHRGQPPELAALPTPE----S 789

  Fly   739 EPVLLPQPPPPNKMHSPK----NTLRK---------PPMHQ-MHQG--PNSETLFQFQPDGYNTQ 787
            .|||..:.....|.||.|    ...||         ||.|. :..|  |::..|.....| |||.
  Rat   790 TPVLHQKTLQAMKSHSDKAHGHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHD-YNTS 853

  Fly   788 QSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHR 852
            .|     |....::.:.:.:........|:.|..:::|::.||.|..|        :|
  Rat   854 FS-----NSNAHKAEKKLQNVDHPLTKSSSKREHRRSVDSRNTLNDLL--------KH------- 898

  Fly   853 SNSPQQQQQ----QSQQPHSSSGSSPVMSNSSSSPAPPSSSPS----PQESPKNCSYIYRDXLIC 909
            .|.|....:    :....|.:....||...|...|..|:...|    |...|:|......|  :.
  Rat   899 LNDPNSNAKAIMGEIHMAHQTLMLDPVGPMSEVPPKVPNREASLYSPPSTLPRNSPTKRVD--VP 961

  Fly   910 NTKSMPL--IQAQSTHAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGR------------TYAK 960
            .|..:|:  ::.|..:.:...|.|.....|....:|.....:|.|.:.|            .|.:
  Rat   962 TTPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQ 1026

  Fly   961 SMPVTPVQPQSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPH 1025
            ..||: |..|..|:...||.     |:......|           .:.|.||....||.|...|.
  Rat  1027 GTPVS-VHLQPSLSRQSSYT-----SNGTLPRTG-----------LKRTPSLKPDVPPKPSFVPQ 1074

  Fly  1026 LIASPPL 1032
            ..:..||
  Rat  1075 TTSVRPL 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	197/483 (41%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/51 (27%)
Sema6d	XP_038960912.1	Sema	49..513	CDD:417757	198/483 (41%)
Sema6d	XP_038960912.1	PSI	514..>543	CDD:396154	13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860