DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema4a

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001012078.2	Gene:	Sema4a / 310630	RGDID:	1304636	Length:	762	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	219/737 - (29%)
Similarity:	332/737 - (45%)	Gaps:	134/737 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGP-EDVLKFVGNESVVD-HFKLVTKD 103
            ||.|:    .|:||||: |...:.:..|..: |::....|. ...|.|...:.:.| ...|::.|
  Rat    16 LSVFF----FQLFLLLS-LPPASGTGGQGPV-PRVKYHAGDGHRALSFFQQKGLRDFDTLLLSGD 74

  Fly   104 GNSLLIGARNTVFNLSIHD--LVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPG 164
            ||:|.:|||..:..|:|.:  :...:.:: |.:.|.....|..|.|..|. |.|:||::|..:..
  Rat    75 GNTLYVGAREAILALNIENPGIPRLRNMIPWPASEKKKNECAFKKKSNETQCFNFIRVLVSYNAT 139

  Fly   165 RLFVCGTNSFRPMCNTYIISDSNYTLEATK----NGQAVCPYDPRHNSTSVLADNELYSGTVADF 225
            .|:.|||.:|.|.| |:|....::.|...|    :|:...|:||.|..|:||.|..|||||:.:|
  Rat   140 HLYACGTFAFSPAC-TFIELQDSFLLPILKDKVTDGKGQSPFDPAHKHTAVLVDGMLYSGTMNNF 203

  Fly   226 SGSDPIIYR----EP-LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVA 285
            .||:||:.|    :| |:|:.:........:||::......|||||.|||.||....:...||||
  Rat   204 LGSEPILMRTLGSQPVLKTDIFLRWLHPDASFVAAIPSTQVVYFFFEETASEFDFFEELYTSRVA 268

  Fly   286 RVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNT 350
            :|||.|.||....:.:||:|||::|.|:.||..|  ||.|:.|..|   ...|.|...||.|| |
  Rat   269 QVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLP--FNIIRHAVLL---PADSPSVPRIYAVF-T 327

  Fly   351 PSNSIPG---SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDP 412
            ....:.|   ||||||:|.||...|:|::||.....|.|.....::| :||||||.....:  |.
  Rat   328 SQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEV-NPRPGSCSMGPSS--DK 389

  Fly   413 TLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKS 477
            .|.|:|.|.||||:|   ...|:||::...|  ||:||:. .:...|.::.|:::||..|.:.|:
  Rat   390 ALTFMKDHFLMDEHV---VGAPLLVKSGVEY--TQLAVET-AQGLDGSSHVVLYLGTSTGSLHKA 448

  Fly   478 VNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGS----YDDGKLIIVTDSQV 538
            |..:::      ::.::|||.:...|||::||::.       |..|:    :.:|
  Rat   449 VVPQNS------SAYLVEEIQLSPNSEPVQNLQLA-------PTQGAVFAGFSEG---------- 490

  Fly   539 VAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-------------RSHGAPRWLEENYFYQ 590
             ..::.|.:.....||.:||..:||:||||..:..|             ...|.|.|
  Rat   491 -IWRVPRANCSVYKSCVDCVLARDPHCAWDPESRLCSLLSGSPLTWKQDMERGNPEW-------- 546

  Fly   591 NVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEI-----IDNIDKNFEGPQIS 650
                    ||..|.:                  ....||||..|.|     :.|.......||:|
  Rat   547 --------ACARGPM------------------ARSPRRQSSPQLIKEVLTVPNSILELPCPQLS 585

  Fly   651 ADIINAQY-------TVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFE 708
            |   .|.|       .:......|..||:..|......|.:   :|...| :...||...|....
  Rat   586 A---LASYHWSHGKAKIPEASSTVYNGSLLLLPQDGVGGLY---QCVATE-NGYSYPVVSYWVDS 643

  Fly   709 QRQNVNSFPSSCRIQQEPKLLP 730
            |.|.:...|....:.:|...:|
  Rat   644 QDQPLALDPELAGVPRERVQVP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	159/475 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/46 (26%)
Sema4a	NP_001012078.2	Sema	57..497	CDD:301699	160/479 (33%)
		PSI	498..542	CDD:214655	11/43 (26%)
		Ig	567..639	CDD:299845	16/78 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910