DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema4d

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001164034.1	Gene:	Sema4d / 306790	RGDID:	1310554	Length:	862	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	191/589 - (32%)
Similarity:	303/589 - (51%)	Gaps:	85/589 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VFLLLTVLVIGNQSAWQENIR----PKLYVELGPEDVLKFVGNESVVDHFK--LVTKDGNSLLIG 110
            :||.|.       :.|:..:.    |::..|.|...::||  :|..:.::.  |:::|.::|.:|
  Rat    10 LFLALV-------AVWRTAVAFAPVPRITWEHGEVGLVKF--HEPGIFNYSSLLMSEDKDTLYVG 65

  Fly   111 ARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGTNS 173
            ||..||.::..|:.|:|..| |...||....|..|||.::. |.||||::...|...|:|||||:
  Rat    66 AREAVFAVNALDISEKQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIRVLQPLSSTSLYVCGTNA 130

  Fly   174 FRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR---- 234
            |:|.|:...::...: |..:::|:..||:||.|:.|||:...||||||..:|.||:|||.|
  Rat   131 FQPTCDHLNLTSFKF-LGKSEDGKGRCPFDPAHSYTSVMVGGELYSGTSYNFLGSEPIISRNSSH 194

  Fly   235 EPLQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCK 289
            .||:|| |....||.|:||          .:..:.|.|||||.|.:||:....|.:..|||||||
  Rat   195 SPLRTE-YAIPWLNEPSFVFADVIHKSPDGTEAEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCK 258

  Fly   290 WDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNS 354
            .|:||....:.:||||||:||.||.| |....||.:|....|   :...:...:.|.||....|:
  Rat   259 GDQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNILQDVFVL---RAPGLKEPVFYAVFTPQLNN 319

  Fly   355 IPGSAVCAFALQDIADTF-EGQFKEQTGI---NSNWLPVNNAKVPDPRPGSC-HNDSRA------ 408
            :..|||||:.|..:...| .|::.:...:   ::.|:.. |..||.||||:| .:::||
  Rat   320 VGLSAVCAYTLSTVEAVFSRGKYMQSATVEQSHTKWVRY-NGPVPTPRPGACIDSEARAANYTSS 383

  Fly   409 --LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDH 471
              |||.||.|:|.|.|||::|....::|.|::....|  |||.|| :.:...|..|||:|:.||.
  Rat   384 LNLPDKTLQFVKDHPLMDDSVTPIDNRPKLIKKDVNY--TQIVVD-RTQALDGTFYDVMFLSTDR 445

  Fly   472 GKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDS 536
            |.:.|:|             ::.:|:.|:.:::..::.|.|.::.....|      |:..:...|
  Rat   446 GALHKAV-------------ILAKEVHVVEETQLFQDFEPVLSLLLSSKK------GRKFVYAGS 491

  Fly   537 QVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC----RSHGAPR-WLEENYFYQNVATGQ 596
            ....:|.......|.:||.:||..:||||||......|    ::.|:.| |:::       .:|.
  Rat   492 NSGVVQAPLAFCGKHSSCEDCVLARDPYCAWSPAIKACVTLHQAEGSSRGWIQD-------MSGD 549

  Fly   597 HAAC 600
            .::|
  Rat   550 TSSC 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	165/485 (34%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/37 (32%)
Sema4d	NP_001164034.1	Sema_4D	31..501	CDD:200520	169/500 (34%)
		PSI	503..548	CDD:396154	15/51 (29%)
		Ig	563..646	CDD:416386
		Ig strand B	569..577	CDD:409353
		Ig strand C	583..589	CDD:409353
		Ig strand C'	591..594	CDD:409353
		Ig strand D	600..604	CDD:409353
		Ig strand E	607..614	CDD:409353
		Ig strand F	620..629	CDD:409353
		Ig strand G	633..646	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910