DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema5b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_038944267.1	Gene:	Sema5b / 303901	RGDID:	1308914	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	1027	Identity:	304/1027 - (29%)
Similarity:	443/1027 - (43%)	Gaps:	237/1027 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EDVLKFVGN---ESVVDHFKL-VTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCL 142
            ||:..:|.|   ..|.|..:| :....|.|::||||.:|.||:.::...|...|.|.||..:.|.
  Rat    51 EDLKPWVSNFTYPGVRDFSQLALDPSRNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQ 115

  Fly   143 VKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHN 207
            .|||.||.||||:|:::| |..::|:||||:|.|:|::..:.:.:..:|.. ||.|.||||||||
  Rat   116 SKGKTEEECQNYVRVLIV-SGRKVFMCGTNAFSPVCSSRQVGNLSRAIEKI-NGVARCPYDPRHN 178

  Fly   208 STSVL-ADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFF 266
            ||:|: :..|||:.||.||||.||.|||.     ||:|.||:|..||.||||::|..|.|.|||.
  Rat   179 STAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAFDIGLFAYFFL 243

  Fly   267 RETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNL 331
            ||.|||. :||:.:|||||||||.|.||.....:.||:|:|:|||||.||:.|||:||:|||.:|
  Rat   244 RENAVEH-DCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHL 307

  Fly   332 VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
            .|       ..||||||.|..|||..||||||.|..|:..|.|.|:.|....:.|||:.| .:|:
  Rat   308 PE-------QDLIYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENPRAAWLPIAN-PIPN 364

  Fly   397 ------PRPGSCHN-DSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVD-AQ 453
                  |..|...| ..|:|.|....|     ||.|.|.....:|.:.:.|.  ||:.:.|| .|
  Rat   365 FQCGTLPETGPNENLTERSLQDAQRLF-----LMSEAVQPVTPEPCVTQDSV--RFSHLVVDLVQ 422

  Fly   454 IKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLT--KSEPIRNLEIVRTMQ 516
            .|   ...|.|:::||:.|.|:|:::..|.    .:....:||:.||.  :.||:|:|.|:.:.:
  Rat   423 AK---DTLYHVLYIGTESGTILKALSTASR----SLRGCYLEELHVLPPGRLEPLRSLRILHSAR 480

  Fly   517 YDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPR 581
                        .|.:....:|:.:.|.||  ....|...|:..:||||.||.....|.:
  Rat   481 ------------ALYVGLSDRVLRVPLERC--SAYLSQGACLGARDPYCGWDGKRQLCST----- 526

  Fly   582 WLEE----NYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDS--------RRQSKDQ 634
             ||:    :.:.||:     .|||...: ::|...|....:: ..:.||.        |.:|.|.
  Rat   527 -LEDSSNMSLWIQNI-----TACPVRNV-TRDGGFGPWSPWK-PCEHLDGDNSGSCLCRARSCDS 583

  Fly   635 --------EIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGF------------ 679
                    |.:        ||.|  .|.|..........:..|....|..:||
  Rat   584 PRPRCGGLECL--------GPAI--HIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCSNPAP 638

  Fly   680 -FTGYFCGRRCHKDE--DDNLPYPDTEY-------------------EYFEQRQNVNSFPSSCRI 722
             ..|..|..:..::.  ::|.|.|...:                   ......:|.||.| .|.:
  Rat   639 RHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCGGGVQSRRRSCENGNSCP-GCGV 702

  Fly   723 QQE---PKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQ---- 780
            :.:   |:..|:|...|...|.|                    |::....|...|..|:|.
  Rat   703 EFKTCNPEACPEVRRNTPWTPWL--------------------PVNVTQGGARQEQRFRFTCRAP 747

  Fly   781 -PDGYNTQQSYR-------GRDNFGTLRSHQVMGDNYRRGD--------GFST------------ 817
             ||.:..|...|       ..|..|...:..::.|..|.|.        |::|
  Rat   748 LPDPHGLQFGKRRTETRTCPADGTGACDTDALVEDLLRSGSTSPHTLSGGWATWGLWSSCSRDCE 812

  Fly   818 --TRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQ---------SQQPHSSSG 871
              .|..|:...|...||..|       |..|...:::..:||....:         ||...|..|
  Rat   813 LGFRVRKRTCTNPEPRNGGL-------PCVGDAAEYQDCNPQACPVRGAWSCWTAWSQCSASCGG 870

  Fly   872 SSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRDXLICNTKSMPLIQAQS----------THAQP 926
            .....:.|.:|||     |||.|.  .|..::.: .:|.|::.|  :..|          ..||.
  Rat   871 GHYQRTRSCTSPA-----PSPGED--ICLGLHTEEALCATQACP--EGWSLWSEWGVCTEDGAQS 926

  Fly   927 HPQSHPHPLPPPGPTTPPAQPRARSPMIGRTYAKSMPVTPVQPQSPLAETPS 978
            ..:|....:|.||.....:......|     |:: :||  :.|.|.:.||.|
  Rat   927 RSRSCEELVPGPGACVGNSSQSRPCP-----YSE-IPV--ILPASSVEETAS 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	191/471 (41%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/33 (33%)
Sema5b	XP_038944267.1	Sema	60..496	CDD:417757	190/472 (40%)
		PSI	497..544	CDD:396154	16/59 (27%)
		TSP1	609..662	CDD:214559	8/52 (15%)
		TSP1	667..713	CDD:214559	6/46 (13%)
		TSP1	798..850	CDD:214559	11/58 (19%)
		TSP1	855..907	CDD:214559	15/58 (26%)
		TSP_1	911..952	CDD:417691	7/40 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810