DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema3ab

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_571136.1	Gene:	sema3ab / 30267	ZFINID:	ZDB-GENE-991209-6	Length:	778	Species:	Danio rerio

Alignment Length:	853	Identity:	235/853 - (27%)
Similarity:	375/853 - (43%)	Gaps:	179/853 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YGWMQVFLLLTVLVIGNQSAWQEN------IRPKLYVELGPEDVLKFVG--NESVVDHFKLVTKD 103
            |.|..|.|:.|::.....:..|.:      ::|.....|...::|.|.|  |.|.. |..|:.::
Zfish     3 YLWWIVLLIWTLIAPERGTVAQRSKSNVPRLKPSYKEMLESNNLLTFNGLANSSAY-HTFLLDEE 66

  Fly   104 GNSLLIGARNTVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRL 166
            ...|.:||::.|.:.::.|: ::||.:.|.|.......|...||| ::.|.|:|:::...:...|
Zfish    67 RGRLFVGAKDHVLSFNLVDINMDQQLISWPSSPSRRDECKWAGKDVQKECANFIKVLQPFNQTHL 131

  Fly   167 FVCGTNSFRPMC-----------NTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSG 220
            :.|||.:|.|:|           ||:.:..|      .:||:...||||:..:.|:|.|.|||:|
Zfish   132 YACGTGAFHPVCAHVEVGKRSEDNTFRLGSS------FENGRGKSPYDPKLQTASMLIDGELYAG 190

  Fly   221 TVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEF 273
            |.|||.|.|..|:|     .|::|||:||..||.|.||       |...:.|.:|.||||.|::.
Zfish   191 TSADFMGRDFAIFRTLGKHHPIRTEQHDSRWLNDPRFVSVHLIPESDNAEDDKIYLFFRENAIDG 255

  Fly   274 INCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEGQY 336
            ....||.::|:.::||.|.||.....|:||:|||:||.||:||  ....:|:|:|...
Zfish   256 EQISKATHARIGQLCKNDFGGHRSLVNKWTTFLKARLVCSVPGLNGIDTHFDELQDVF------- 313

  Fly   337 GSMSSK-----LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
             .||||     :||.||.|.||...|||||.:::.||...|.|.:..:.|.|..|:|..| :||.
Zfish   314 -LMSSKDPKNPIIYAVFTTSSNIFKGSAVCMYSMADIRRVFLGPYAHRDGPNYQWVPFLN-RVPY 376

  Fly   397 PRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQI 454
            ||||:|       ...::..||..:.|.::|..|...|....:.||:::|...|:||||.|| ::
Zfish   377 PRPGTCPSKTFDGFESTKDFPDDVITFARSHPAMYNPVFPINNHPIIIKTDVDYQFTQIVVD-RV 440

  Fly   455 KTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQ 519
            :...|: |||:|:|||.|.::|.|:.......| :..|::||:.|..:...|..:|:....|
Zfish   441 EAEDGQ-YDVMFIGTDMGTVLKVVSIPRGTWHD-LEEVLLEEMTVFREPTAITAMELSTKQQ--- 500

  Fly   520 PKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKI-TSCSECVALQDPYCAWDKIAGKCRSHGAPRWL 583
                     :|.:.:...|..:.||||  |.. .:|:||...:|||||||  ..:|
Zfish   501 ---------QLYLGSAIGVSQMPLHRC--DVYGKACAECCLARDPYCAWD--GSQC--------- 543

  Fly   584 EENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDN-------ID 641
             ..||            |:.|..::          |.|:...|...|..|.:..|.       :|
Zfish   544 -SRYF------------PTAKRRTR----------RQDIRNGDPLTQCSDLQHHDEADGEAGLLD 585

  Fly   642 KNFEGPQISADIINA------------------QYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR 688
            |...|.:.|:..:..                  .:.:|......:.|:...||:         |.
Zfish   586 KTVYGVENSSSFLECSPKSQRALIYWQFQRHGEDHKLEIKSDERVLGTEQGLLI---------RS 641

  Fly   689 CHKDEDDNLPYPDTEYEYFEQ---RQNVNSFPS---SCRIQQEPKLLPQVEE-----VTYAEPVL 742
            .|: :|..:.|.......|.|   |..:|..|:   ...:.::|   |...:     :.|.:.:.
Zfish   642 LHQ-KDSGVYYCHAVEHGFIQTLLRLTLNVIPAEHLDDLLHRDP---PDTNDPANGKMWYRDFLS 702

  Fly   743 LPQPPPPNKM---------HSPKNTLRKPPMHQMHQGPNSETLFQFQPDG--YNTQQSYRGRDNF 796
            |..||.||.:         ...|...:|..:....|...|:.|...|...  ...|::.:||:.
Zfish   703 LINPPSPNSVDQLCEQVWKRERKQRRQKANLLHASQSHTSQILHSSQSHAKWKLLQENKKGRNR- 766

  Fly   797 GTLRSHQV 804
               |:|::
Zfish   767 ---RTHEM 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	163/493 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/34 (41%)
sema3ab	NP_571136.1	Sema	27..519	CDD:301699	171/524 (33%)
		PSI	517..>553	CDD:214655	18/61 (30%)
		Ig_Semaphorin_classIII	583..673	CDD:143279	16/99 (16%)
		IG_like	586..654	CDD:214653	11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..778		10/49 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920