DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema3aa

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_571135.1	Gene:	sema3aa / 30266	ZFINID:	ZDB-GENE-991209-3	Length:	860	Species:	Danio rerio

Alignment Length:	928	Identity:	257/928 - (27%)
Similarity:	422/928 - (45%)	Gaps:	193/928 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VFLLLTVLVIGNQSAWQ---ENIRPKL---YVE-LGPEDVLKFVG--NESVVDHFKLVTKDGNSL 107
            :||||..:.:..:.|.|   ||: |:|   |.| |...:::.|.|  |.|..|.| |:..:...|
Zfish     7 IFLLLCGVALPGRVAPQHTKENV-PRLKLSYNEMLESSNLVTFTGLANSSGYDTF-LMDGERGRL 69

  Fly   108 LIGARNTVFNLSIHDLV----EQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLF 167
            |:||.:.||:.   |||    :.:::.|.:.......|...||| .:.|.|::|::...:...::
Zfish    70 LVGAEDHVFSF---DLVNINRDVKQIAWPATPSKRDECKWAGKDLRKDCSNFVRVLQSYNQTHIY 131

  Fly   168 VCGTNSFRPMCNTYII----SDSNYTLEAT--KNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226
            :|||.:|.|:|:...:    .|:.:.|:|.  :||:...||||:..|:|:|.|.||||||.|||.
Zfish   132 ICGTGAFHPICSFLEMGKRAEDNIFRLDANYFENGRGKSPYDPKMQSSSLLLDGELYSGTSADFM 196

  Fly   227 GSDPIIYR-----EPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFINCGKA 279
            |.|..|:|     .|::|||:||..||.|.|:       |...:.|.::.||:|.|::..:.|||
Zfish   197 GRDFAIFRTLGSHHPIRTEQHDSRWLNEPRFLGIHLIPESDNPEDDKIFLFFKENAMDGEHTGKA 261

  Fly   280 IYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEGQYGSMSSK 342
            ..||:.::||.|.||.....|:||:|||::|.||:||  ....:|:|:|...        .||:|
Zfish   262 TISRIGQLCKNDMGGHRSLVNKWTTFLKAKLTCSVPGLNGIDTHFDELQDVF--------LMSAK 318

  Fly   343 -----LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC 402
                 :||.||.|.||...|||:|.:::.||...|.|.:..:.|.|..|:|. ..:||.||||:|
Zfish   319 DPKNPVIYAVFTTSSNIFRGSAICMYSMADIRRVFLGPYAHRDGPNYQWVPF-QGRVPYPRPGTC 382

  Fly   403 -------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGK 460
                   .:.::.|||..:.|.:.|..|...|.....:||:|||:..|:|||:.|| :::...|:
Zfish   383 PSKTFGGFDSTKDLPDDVITFARLHPAMYNPVQPMGGKPIVVRTNVEYQFTQLVVD-RVEAEDGQ 446

  Fly   461 TYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSY 525
             |||:|:|||.|.::|.|.. ..:|...:..||:||:.|..:..||..:|:....|
Zfish   447 -YDVMFIGTDLGTVLKVVTI-PRESWHDLEEVVLEEMTVFREPTPITAMELSTKQQ--------- 500

  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKI--TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYF 588
               :|.:.:|..:..:.||||   ::  .:|:||...:|||||||  ..:|          ..||
Zfish   501 ---QLYLGSDLGISQMPLHRC---EVYGKACAECCLARDPYCAWD--GTEC----------SRYF 547

  Fly   589 YQNVATGQHAACPSGKINSK--DANAGEQKGFRNDM---DLLDSRRQSKDQEI--IDNIDKNFE- 645
                        |:.|..::  |...|:.....:|:   |.|:.....:::.:  ::|.....|
Zfish   548 ------------PTAKRRTRRQDIRNGDPLSQCSDLHHNDDLEGYSSVEERSVYGVENSSMFLEC 600

  Fly   646 GPQISADII-------NAQYTVETLVMAVLAGSIFSLLVGFFT----GYFCGRRCHKDEDDNLPY 699
            .|:....:|       |.:...|.::...|:.:...||:...|    |.|.   ||.
Zfish   601 SPKSQRALIYWQLQKPNDERKHEIVIDERLSLTGQGLLIRSLTQADSGVFL---CHA-------- 654

  Fly   700 PDTEYEYFE--QRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKP 762
              .|:.:.:  :|.|:...||.           :|.|       ||.:....:|..:||:.|...
Zfish   655 --VEHGFIQPLRRINLQVIPSQ-----------RVGE-------LLLRAGTNDKDPAPKHKLWYR 699

  Fly   763 PMHQMHQGPNSETLFQFQPDGYNTQQSYRGRD----NFGTLRSHQVMGDNYRRGDGFSTT----- 818
            ....:.:.|:..::.:|....:..::..:|:.    |.||       |.:.:......||
Zfish   700 DFMSLLEHPDLNSVDEFCERIWKREKKPKGKKAPKVNPGT-------GVSIKNEKTPQTTAQSLQ 757

  Fly   819 ------RSVKKAVNNTNTR--NRSLGRARRQPPRHGIVTQHRSNSPQQQ---QQQSQQPHSSSGS 872
                  ::..|..||.:.:  .:|.|..|.|.|...:.|:.:|..|..|   :.|..||
Zfish   758 NPTQRAQNAPKVPNNPSVQIFPKSTGLQRSQSPGGTVSTESQSTKPDTQKASESQRAQP------ 816

  Fly   873 SPVMSNSSSSPAPPSSSP 890
                :.:...|..|...|
Zfish   817 ----NQAKKGPQTPQRGP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	165/491 (34%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/35 (37%)
sema3aa	NP_571135.1	Sema	26..519	CDD:301699	177/524 (34%)
		PSI	517..569	CDD:214655	19/78 (24%)
		Ig_Semaphorin_classIII	583..673	CDD:143279	17/102 (17%)
		IG_like	586..654	CDD:214653	13/70 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..860		25/123 (20%)
		DUF4887	<744..859	CDD:292845	20/97 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920