DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema4f

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_062145.1	Gene:	Sema4f / 29745	RGDID:	3658	Length:	776	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	212/792 - (26%)
Similarity:	340/792 - (42%)	Gaps:	149/792 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVL---VIGN--QSAWQENIRPKLYVELGPED--VLKFVGNESVVDHFKLVTKDGNSL 107
            :.:.|||.:|   |.|.  :|.      |:..:.:...|  :.:|..:.:......||....::|
  Rat    24 LSLLLLLAILSAPVCGRVPRSV------PRTSLPISEADSYLTRFAASHTYNYSALLVDPASHTL 82

  Fly   108 LIGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGT 171
            .:|||:::|.|::....|: :|:.|..||...:.|..|||.|:.|.|:|:|:.:.:...|..|||
  Rat    83 YVGARDSIFALTLPFSGERPRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIVNASHLLTCGT 147

  Fly   172 NSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREP 236
            .:|.|.|....:| |...:|..::|:..||::|...|.:|:|...||:.||.:|.|::|||.|..
  Rat   148 FAFDPKCGVIDVS-SFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAV 211

  Fly   237 LQTEQY---DSLS--LNAPNFVSSFTQG----------DFVYFFFRETAVEFINCGKAIYSRVAR 286
            .:.|.:   ::||  ||||.||::....          |.::|||.||:....:..:....||||
  Rat   212 GRAEDWIRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVAR 276

  Fly   287 VCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTP 351
            ||..|.||....:.|||:|||:.|.|  ||......:.:..|...:..|.|: .:.:.||:|::.
  Rat   277 VCAGDLGGRKTLQQRWTTFLKADLLC--PGPEHGRASGVLQAMAELRPQPGA-GTPIFYGIFSSQ 338

  Fly   352 SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---------HNDSR 407
            ......||||||..|||.....|.|:|.....:..|||.:.:||.||||.|         ...|.
  Rat   339 WEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIANNMKLQQFGSSL 403

  Fly   408 ALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDA-QIKTPGGKTYDVIFVGTDH 471
            :|||..|.||:.|.|||..|.....:|:||.|.|.|    :.|.| ::.:..||.|||:::||:.
  Rat   404 SLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAY----LRVVAHRVTSLSGKEYDVLYLGTED 464

  Fly   472 GKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDS 536
            |.:.::|...:..|       |:|::.:..:.:|:.::::             |.|. |::.:.:
  Rat   465 GHLHRAVRIGAQLS-------VLEDLALFPEPQPVESMKL-------------YHDW-LLVGSHT 508

  Fly   537 QVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSH-GAPRWLEEN-------------- 586
            :|..:....|  .::.|||||:..|||.|||......|.:| |..|.:.::
  Rat   509 EVTQVNTSNC--GRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSSLCPKEP 571

  Fly   587 -----YFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNF-- 644
                 .|...|||..|...|....::..:....|.   :.:..|..||...:..:.......:
  Rat   572 GEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQP---SGVTALTPRRDGLEVVVTPGAMGAYAC 633

  Fly   645 EGPQISADIINAQYTV------------ETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNL 697
            |..:..|..:.|.|::            .|:|.|.|.|.:..:|....|....|||..:.....|
  Rat   634 ECQEGGAARVVAAYSLVWGSQRGPSNRAHTVVGAGLVGFLLGVLAASLTLLLIGRRQQRRRQREL 698

  Fly   698 -------------PYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYA----------- 738
                         |...|.|.                 |..|...|:.|.:..|
  Rat   699 LARDKVGLDLGAPPSGTTSYS-----------------QDPPSPSPEDERLPLALGKRGSGFGGF 746

  Fly   739 -EPVLLPQPPPP 749
             .|.||...|.|
  Rat   747 PPPFLLDSCPSP 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	148/480 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/34 (41%)
Sema4f	NP_062145.1	Sema_4F	57..516	CDD:200522	149/487 (31%)
		PSI	517..568	CDD:279745	16/52 (31%)
		Ig	575..654	CDD:299845	14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..741		8/55 (15%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q9Z123	774..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910