Protein Alignment Sema1a and Sema6c

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_059004.1
• Gene: Sema6c / 29744
• RGDID: 3659
• Length: 960
• Species: Rattus norvegicus
• Alignment Length: 1115
• Identity: 320/1115 - (28%)
• Similarity: 442/1115 - (39%)
• Gaps: 288/1115 - (25%)

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVEL----------GPEDVLKFVGNESVVDHFKLVTKDG 104
            |.:.|||.:.:...|:|:.::..|.|..:|          |.||  ..|..|..:|..:.:|.:
  Rat     8 MPLLLLLLLSLPQAQTAFPQDPIPLLTSDLQGTSPSSWFRGLED--DAVAAELGLDFQRFLTLN- 69

  Fly   105 NSLLIGARNTVFNLSI------HDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSP 163
            .:||:.||:.||:..:      ..||..:.|.|.|  .|.:.|.|:||..:.|.||||::|....
  Rat    70 RTLLVAARDHVFSFDLQAQEEGEGLVPNKFLTWRS--QDMENCAVRGKLTDECYNYIRVLVPWDS 132

  Fly   164 GRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGS 228
            ..|..||||||.|:|.:|.|:......|.. :|||.||:|...::.::.|:..|||.|.|||..|
  Rat   133 QTLLACGTNSFSPVCRSYGITSLQQEGEEL-SGQARCPFDATQSTVAISAEGSLYSATAADFQAS 196

  Fly   229 DPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVC 288
            |.::||.     ||::.:|||..|..|:||.:...||.|||||||.:||....|:..:|||||||
  Rat   197 DAVVYRSLGPQPPLRSAKYDSKWLREPHFVYALEHGDHVYFFFREVSVEDARLGRVQFSRVARVC 261

  Fly   289 KWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPS 352
            |.|.|| |......||||||.|||||:|||..|||:.:||    :.|.........::|||.|.:
  Rat   262 KRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQS----LTGPVNLHGRSALFGVFTTQT 322

  Fly   353 NSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRAL 409
            |||||||||||.|.||...|||:||||..::..|.||:..|||.||||||        .:.|:.|
  Rat   323 NSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAALFSSSQDL 387

  Fly   410 PDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKI 474
            ||..|.|||.|.|:|..||....||:|..||... .||:|||.........|  |:|:|::.|.:
  Rat   388 PDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTT--VLFLGSNDGTV 449

  Fly   475 IK-------SVNAESADSADKVTSVVIEEIDVLT------KSEP-----IRNLEIVRTMQYDQPK 521
            :|       |:..|         .:::||||..:      |..|     |..||:
  Rat   450 LKVLPPGGQSLGPE---------PIILEEIDAYSHARCSGKRSPRAARRIIGLEL---------- 495

  Fly   522 DGSYDDGKLIIVTDSQVVAIQLHRC--HNDKITSCS-ECVALQDPYCAWDKIAGKCRSHGAPRWL 583
              ..:..:|.:.....:|.:.|.||  |.    :|. .|:|..||||.|.:..| |.:...|...
  Rat   496 --DTEGHRLFVAFPGCIVYLSLSRCARHG----ACQRSCLASLDPYCGWHRFRG-CVNIRGPGGT 553

  Fly   584 EENYFYQNVATGQHAACPSGKINSK------------------------DANAGEQ--------K 616
            :.: ...|..:.:|..|..|...|:                        ||:.|.|        :
  Rat   554 DVD-LTGNQESMEHGDCQDGATGSQSGPGDSAYVLLGPGPSPETPSSPSDAHPGPQSSTLGAHTQ 617

  Fly   617 GFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFT 681
            |.|.|:....:.|             :...|.:.|.:..|         ..|..|:..|||.
  Rat   618 GVRRDLSPASASR-------------SIPIPLLLACVAAA---------FALGASVSGLLVS--- 657

  Fly   682 GYFC-----GRRCHKD-EDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEP 740
               |     .||..|| |...||.|             .|..|..|:....
  Rat   658 ---CACRRANRRRSKDIETPGLPRP-------------LSLRSLARLHGGG-------------- 692

  Fly   741 VLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQ--------------SYR 791
               |:||||     ||:       ....|.|...|.|...|:|.:..:              ...
  Rat   693 ---PEPPPP-----PKD-------GDAAQTPQLYTTFLPPPEGGSPPELACLPTPETTPELPVKH 742

  Fly   792 GRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSP 856
            .|.:.|....:| .|:|...|.|                |.|....|....|| .:|.......|
  Rat   743 LRASGGPWEWNQ-NGNNASEGPG----------------RPRGCSAAGGPAPR-VLVRPPPPGCP 789

  Fly   857 QQQQQ-----------QSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRDXLICN 910
            .|:.:           ...|| ...||.|:.|...:| .||:|.|.
  Rat   790 GQEVEVTTLEELLRYLHGPQP-PRKGSEPLASAPFTS-RPPASEPG------------------- 833

  Fly   911 TKSMPLIQAQSTHAQPHPQSHPHPL----PPPGP-TTPPAQP--RARSPMIGRTYAKSMPV-TPV 967
                   .|....:.|.|:....||    ||.|. ..|..:|  .|.:|.:|.:.::.:|. |..
  Rat   834 -------AALFVDSSPMPRDCVPPLRLDVPPDGKRAAPSGRPALSAPAPRLGVSGSRRLPFPTHR 891

  Fly   968 QPQSPLAETPS--YELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPHLIASP 1030
            .|...|...||  ...|.........:.|..|..........|..|  .::|.||      :|:|
  Rat   892 APPGLLTRVPSGGPSRYSGGPGRHLLYLGRPDGHRGRSLKRVDVKS--PLSPKPP------LATP 948

  Fly  1031 PLPPPRRFRF 1040
            |.|.|....|
  Rat   949 PQPAPHGSHF 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	188/492 (38%)
		PSI	545..>579	CDD:214655	13/36 (36%)
Sema6c	NP_059004.1	Sema	52..516	CDD:417757	188/495 (38%)
		PSI	517..>538	CDD:396154	10/24 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..624		12/69 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..725		14/68 (21%)
		PHA03307	730..>956	CDD:223039	58/279 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..792		13/64 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	806..960		44/189 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.820