DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema3g

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001094352.1	Gene:	Sema3g / 290562	RGDID:	1306079	Length:	780	Species:	Rattus norvegicus

Alignment Length:	616	Identity:	180/616 - (29%)
Similarity:	275/616 - (44%)	Gaps:	92/616 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDL 123
            |:..|:||          :.|||...|..  ....:|.::      :.|.:|.|:.:::|.:...
  Rat    41 LLTTNRSA----------IFLGPRGSLDL--QVMYLDEYR------DRLFLGGRDALYSLRLDQA 87

  Fly   124 VEQQRLVWTSPEDDTKM-CLVKGKDE-EACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISD- 185
            ....|.|...|:...|: |:.||||. ..|.|::|::...:...|..|||.:|:|:|....:..
  Rat    88 WPDPREVLWPPQPGQKVECVRKGKDPLTECANFVRVLQPHNRTHLLACGTGAFQPICTFITVGHR 152

  Fly   186 SNYTL----EATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR----EPLQTEQY 242
            ..:.|    .:.:||:..||::|.....|.....|||:|..|||.|.:.:|:|    .|......
  Rat   153 GEHVLHLDPSSIENGRGRCPHEPSRPFASTFVGGELYTGLTADFLGREAMIFRSGGPRPALRSDS 217

  Fly   243 DSLSLNAPNFV-------SSFTQGDFVYFFFRETAVE-FINCGKAIYSRVARVCKWDKGGPHRFR 299
            |...|:.|.||       :|....|.|||||.||... ....|....|||.|||..|.||.....
  Rat   218 DQSLLHDPRFVMAARIPDNSDRDDDKVYFFFSETVPSPDGGPGHVTVSRVGRVCVNDAGGQRVLV 282

  Fly   300 NRWTSFLKSRLNCSI--PGDYPFYFNEIQ--------SASNLVEGQYGSMSSKLIYGVFNTPSNS 354
            |:|::|||:||.||:  ||....:|::::        :..||.           :|.:|:|.|..
  Rat   283 NKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKNLE-----------VYALFSTVSAV 336

  Fly   355 IPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC-----------HNDSRA 408
            ..|.|||.:.:.||.:.|.|.|..:.|....|.|. ..|||.||||.|           ...::.
  Rat   337 FRGFAVCVYHMVDIWEVFNGPFAHRDGPQHQWGPY-GGKVPFPRPGVCPSKMTAQPGRPFGSTKD 400

  Fly   409 LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGK 473
            .||..|.|::.|.||.:.|.....:|:||:|....:..||.|| :::...| ||||||:|||.|.
  Rat   401 YPDEVLQFVRGHPLMFQPVRPRRGRPVLVKTHLAQQLCQIVVD-RVEAEDG-TYDVIFLGTDSGS 463

  Fly   474 IIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQV 538
            ::|.: |.......:...||:||:.|.....||..:||            |.....|.:.:...|
  Rat   464 VLKII-ALQGSGLPEPEEVVLEELQVFKVPTPITEMEI------------SVKRQTLYVGSPLGV 515

  Fly   539 VAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAACPSG 603
            ..:|||:|.... ::|:||...:|||||||   |...:...|...:..:..|::..|..|....|
  Rat   516 ARLQLHQCETYG-SACAECCLARDPYCAWD---GTSCARYRPSSGKRRFRRQDIRHGNPAVQCLG 576

  Fly   604 KINSKDANAG---EQKGFRNDMDLLDSRRQS 631
            :..|:|..:|   ...|..::...|:.|.:|
  Rat   577 QGQSQDKASGLVTRVFGTEHNSTFLECRPKS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	148/494 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/33 (36%)
Sema3g	NP_001094352.1	Sema	50..523	CDD:301699	152/507 (30%)
		PSI	522..568	CDD:214655	14/49 (29%)
		Ig_Semaphorin_classIII	591..676	CDD:143279	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910