DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema4g

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_036106.1	Gene:	Sema4g / 26456	MGIID:	1347047	Length:	837	Species:	Mus musculus

Alignment Length:	865	Identity:	216/865 - (24%)
Similarity:	340/865 - (39%)	Gaps:	226/865 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 YGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK---------LV 100
            :|..|..:|..|||..:...|.    .||...::..|...:.: ...|.:.|||         |:
Mouse     2 WGRLWPLLFSFLTVTAVPGPSL----RRPSRELDATPRLTISY-EELSQIRHFKGQTQNYSTLLL 61

  Fly   101 TKDGNSLLIGARNTVFNLSIHDLVEQ--QRLVW-TSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            .:....||:|||..:|:||..|:.::  :.:.| .|||..:| |..|||:.:. |.|::|.:...
Mouse    62 EEASERLLVGARGALFSLSARDIRDRTHKEIHWEASPEMQSK-CHQKGKNNQTECFNHVRFLQRL 125

  Fly   162 SPGRLFVCGTNSFRPMC-----NTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGT 221
            :....:.|||::|:|:|     .|:|:..|      .:.|:..|||||....|.::.|..||:.|
Mouse   126 NATHFYACGTHAFQPLCAAIDAETFILPTS------FEEGKEKCPYDPARGFTGLIIDGGLYTAT 184

  Fly   222 VADFSGSDPIIYR----EPLQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFF--RETA 270
            ..:|. |.|.|.|    ..|:||:.....||...||          |:....|.:||||  ||..
Mouse   185 RYEFR-SIPDIRRSRHPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEG 248

  Fly   271 VEFINCGKAIY--SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVE 333
            .......::.:  :|||||||.|.||....:.:||||||:||.|.||     .:..::...:|
Mouse   249 SSSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSL-- 306

  Fly   334 GQYGSMSSKLIYGVF--NTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
             ...:.|....|.||  .|...::..||:|.:.|.:|...|.|.|.|.......|...... ||:
Mouse   307 -NADTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRWGRYEGG-VPE 369

  Fly   397 PRPGSC---------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDA 452
            ||||||         :|.|:.||...|:|:|.|.||...|.....:|:|::.:.  |:|.: ...
Mouse   370 PRPGSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNV--RYTHL-TGT 431

  Fly   453 QIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQY 517
            .:.||.|.|||::|:||..|.|.|:|...|.       ..:||||.|..:.:.:.|| ::..||:
Mouse   432 HVSTPAGPTYDLLFLGTADGWIHKAVVLGSG-------MHIIEEIQVFREPQSVDNL-VISPMQH 488

  Fly   518 DQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-------- 574
                       .|.:...|.|:...|..|  .:..||.:|:..:||||.||.....|
Mouse   489 -----------SLYVGAASGVLQFPLSSC--SRYQSCYDCILARDPYCGWDSSIHACMVATTVAN 540

  Fly   575 ------------------RSHGAPRWLEENYFYQNVATGQHAACPSGK----------INSKDAN 611
                              |..|.|..|:.    ::|..|.....|..:          :|...:.
Mouse   541 RTELIQDIERGNRGCEGSRDAGPPPPLKT----RSVLRGDDVLLPCDQPSNLARALWLLNGSKSL 601

  Fly   612 AGEQKGFRNDMD---LLDSRRQSK-------DQEIIDNIDKNFE------------------GPQ 648
            :..|.|:|..:|   :.|::.:..       ::..:..:..::.                  |.|
Mouse   602 SDGQDGYRVGVDGLLVTDTQLEHSGNYGCYAEENGLRMLLASYSLTVRPATPAPAPQAPATPGAQ 666

  Fly   649 ISADIINAQYTVETLVMA----VLAGSIFSLLVGFFTGYFCGRR--------------------- 688
            ::.| :...|.|...::.    :||.|:  |.|....|...|||
Mouse   667 LAHD-MRMFYVVAIAILGGLCLILASSL--LYVACLKGGRRGRRRKYSLGRAGRAGGSAVQLQTV 728

  Fly   689 ---CHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750
               |..:||:.           :..:......|.|.     :::|       .|....|.||||
Mouse   729 SGQCPGEEDEG-----------DDGEGTGGLESGCL-----QIIP-------GEGAPAPPPPPP- 769

  Fly   751 KMHSPKNTLRKPPMHQMHQG 770
                      .||..::..|
Mouse   770 ----------PPPPAELTNG 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/501 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/59 (20%)
Sema4g	NP_036106.1	Sema	47..504	CDD:417757	151/495 (31%)
		PSI	505..555	CDD:396154	11/51 (22%)
		Ig_Sema4B_like	565..648	CDD:409456	10/86 (12%)
		Ig strand B	578..582	CDD:409456	0/3 (0%)
		Ig strand C	590..594	CDD:409456	0/3 (0%)
		Ig strand E	613..617	CDD:409456	1/3 (33%)
		Ig strand F	627..632	CDD:409456	0/4 (0%)
		Ig strand G	644..647	CDD:409456	0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..776		14/88 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910