Protein Alignment Sema1a and Sema4g

DIOPT Version :10

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_036106.1
• Gene: Sema4g / 26456
• MGIID: 1347047
• Length: 837
• Species: Mus musculus
• Alignment Length: 865
• Identity: 216/865 - (24%)
• Similarity: 340/865 - (39%)
• Gaps: 226/865 - (26%)

  Fly    45 YGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK---------LV 100
            :|..|..:|..|||..:...|.    .||...::..|...:.: ...|.:.|||         |:
Mouse     2 WGRLWPLLFSFLTVTAVPGPSL----RRPSRELDATPRLTISY-EELSQIRHFKGQTQNYSTLLL 61

  Fly   101 TKDGNSLLIGARNTVFNLSIHDLVEQ--QRLVW-TSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            .:....||:|||..:|:||..|:.::  :.:.| .|||..:| |..|||:.:. |.|::|.:...
Mouse    62 EEASERLLVGARGALFSLSARDIRDRTHKEIHWEASPEMQSK-CHQKGKNNQTECFNHVRFLQRL 125

  Fly   162 SPGRLFVCGTNSFRPMC-----NTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGT 221
            :....:.|||::|:|:|     .|:|:..|      .:.|:..|||||....|.::.|..||:.|
Mouse   126 NATHFYACGTHAFQPLCAAIDAETFILPTS------FEEGKEKCPYDPARGFTGLIIDGGLYTAT 184

  Fly   222 VADFSGSDPIIYR----EPLQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFF--RETA 270
            ..:|. |.|.|.|    ..|:||:.....||...||          |:....|.:||||  ||..
Mouse   185 RYEFR-SIPDIRRSRHPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEG 248

  Fly   271 VEFINCGKAIY--SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVE 333
            .......::.:  :|||||||.|.||....:.:||||||:||.|.||     .:..::...:|
Mouse   249 SSSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----QYETLRGVCSL-- 306

  Fly   334 GQYGSMSSKLIYGVF--NTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD 396
             ...:.|....|.||  .|...::..||:|.:.|.:|...|.|.|.|.......|...... ||:
Mouse   307 -NADTSSHTHFYAVFTLTTQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRWGRYEGG-VPE 369

  Fly   397 PRPGSC---------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDA 452
            ||||||         :|.|:.||...|:|:|.|.||...|.....:|:|::.:.  |:|.: ...
Mouse   370 PRPGSCITDSLRSRGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNV--RYTHL-TGT 431

  Fly   453 QIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQY 517
            .:.||.|.|||::|:||..|.|.|:|...|.       ..:||||.|..:.:.:.|| ::..||:
Mouse   432 HVSTPAGPTYDLLFLGTADGWIHKAVVLGSG-------MHIIEEIQVFREPQSVDNL-VISPMQH 488

  Fly   518 DQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-------- 574
                       .|.:...|.|:...|..|  .:..||.:|:..:||||.||.....|
Mouse   489 -----------SLYVGAASGVLQFPLSSC--SRYQSCYDCILARDPYCGWDSSIHACMVATTVAN 540

  Fly   575 ------------------RSHGAPRWLEENYFYQNVATGQHAACPSGK----------INSKDAN 611
                              |..|.|..|:.    ::|..|.....|..:          :|...:.
Mouse   541 RTELIQDIERGNRGCEGSRDAGPPPPLKT----RSVLRGDDVLLPCDQPSNLARALWLLNGSKSL 601

  Fly   612 AGEQKGFRNDMD---LLDSRRQSK-------DQEIIDNIDKNFE------------------GPQ 648
            :..|.|:|..:|   :.|::.:..       ::..:..:..::.                  |.|
Mouse   602 SDGQDGYRVGVDGLLVTDTQLEHSGNYGCYAEENGLRMLLASYSLTVRPATPAPAPQAPATPGAQ 666

  Fly   649 ISADIINAQYTVETLVMA----VLAGSIFSLLVGFFTGYFCGRR--------------------- 688
            ::.| :...|.|...::.    :||.|:  |.|....|...|||
Mouse   667 LAHD-MRMFYVVAIAILGGLCLILASSL--LYVACLKGGRRGRRRKYSLGRAGRAGGSAVQLQTV 728

  Fly   689 ---CHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750
               |..:||:.           :..:......|.|.     :::|       .|....|.||||
Mouse   729 SGQCPGEEDEG-----------DDGEGTGGLESGCL-----QIIP-------GEGAPAPPPPPP- 769

  Fly   751 KMHSPKNTLRKPPMHQMHQG 770
                      .||..::..|
Mouse   770 ----------PPPPAELTNG 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/501 (31%)
		PSI	545..601	CDD:396154	17/81 (21%)
Sema4g	NP_036106.1	Sema	47..504	CDD:472829	151/495 (31%)
		PSI	505..555	CDD:396154	11/51 (22%)
		Ig_Sema4B_like	565..648	CDD:409456	10/86 (12%)
		Ig strand A	565..571	CDD:409456	1/9 (11%)
		Ig strand B	575..583	CDD:409456	2/7 (29%)
		Ig strand C	589..595	CDD:409456	0/5 (0%)
		Ig strand C'	597..600	CDD:409456	0/2 (0%)
		Ig strand D	607..611	CDD:409456	2/3 (67%)
		Ig strand E	613..620	CDD:409456	1/6 (17%)
		Ig strand F	626..635	CDD:409456	0/8 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..776		14/88 (16%)