DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and SEMA3D

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001371829.1	Gene:	SEMA3D / 223117	HGNCID:	10726	Length:	777	Species:	Homo sapiens

Alignment Length:	637	Identity:	202/637 - (31%)
Similarity:	320/637 - (50%)	Gaps:	97/637 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVL------KFVGNESVVDHFK--LVTKDGNSLL 108
            :.|.:|:|.:......::|| |:|  :|..:|:|      .|:|:...:| |:  |:.::...||
Human    23 MMLSMTMLFLPVTGTLKQNI-PRL--KLTYKDLLLSNSCIPFLGSSEGLD-FQTLLLDEERGRLL 83

  Fly   109 IGARNTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGT 171
            :||::.:|.||:.||.:. :::.|.:.::..::|.:.|||... |.|:||::...:...::||||
Human    84 LGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQPYNKTHIYVCGT 148

  Fly   172 NSFRPMCNTYI-----ISDSNYTLEA--TKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSD 229
            .:|.|:|. ||     ..|..:.|:.  .::|:..||:||:....||:.|..|||||.:||.|.|
Human   149 GAFHPICG-YIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKD 212

  Fly   230 PIIYRE--P------LQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETAVEFINCGKA 279
            ....|.  |      ::|:..:...||...|:.:|       ...|.:||||||::.|.....|.
Human   213 TAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGSTSDKT 277

  Fly   280 IYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGD--YPFYFNEIQSASNLVEGQYGSMSSK 342
            |.|||.||||.|.||.....|:||:|||:||.|||||.  ...||:|:|....|   ......:.
Human   278 ILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSDGADTYFDELQDIYLL---PTRDERNP 339

  Fly   343 LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHN--- 404
            ::||||.|.|:...|||||.:::.||...|.|.:..:...:..|:.. :.::|.||||:|.:
Human   340 VVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESADHRWVQY-DGRIPYPRPGTCPSKTY 403

  Fly   405 -----DSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDV 464
                 .:|..||..::|||.||:|.::|......|...|.:..||.|||.||..|...|  .|||
Human   404 DPLIKSTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDG--QYDV 466

  Fly   465 IFVGTDHGKIIKSVNAESADSADK--VTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDD 527
            :|:|||.|.::|.|:.    |.:|  :..||:||:.:...|..|.|:|:  :::..|...||.|.
Human   467 MFLGTDIGTVLKVVSI----SKEKWNMEEVVLEELQIFKHSSIILNMEL--SLKQQQLYIGSRDG 525

  Fly   528 GKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNV 592
                      :|.:.|||| :....:|::|...:|||||||   |...|..||
Human   526 ----------LVQLSLHRC-DTYGKACADCCLARDPYCAWD---GNACSRYAP------------ 564

  Fly   593 ATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDS-RRQSKDQEIIDNIDKN 643
             |.:..|      ..:|...|:.  .....|:.|| ..::.|:::|..|:.|
Human   565 -TSKRRA------RRQDVKYGDP--ITQCWDIEDSISHETADEKVIFGIEFN 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	164/492 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
SEMA3D	NP_001371829.1	Sema_3D	61..534	CDD:200513	166/496 (33%)
		PSI	533..570	CDD:214655	16/53 (30%)
		Ig_Sema3	595..686	CDD:409455	4/13 (31%)
		Ig strand B	609..613	CDD:409455
		Ig strand C	621..625	CDD:409455
		Ig strand E	648..652	CDD:409455
		Ig strand F	662..667	CDD:409455
		Ig strand G	679..682	CDD:409455
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920