DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema3g

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001020550.1	Gene:	Sema3g / 218877	MGIID:	3041242	Length:	780	Species:	Mus musculus

Alignment Length:	569	Identity:	179/569 - (31%)
Similarity:	262/569 - (46%)	Gaps:	86/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDL 123
            |:..|:||          :.|||...|..  ....:|.::      :.|.:|:|:.:::|.:...
Mouse    40 LLSTNRSA----------IFLGPRGSLDL--QVMYLDEYR------DRLFLGSRDALYSLRLDQA 86

  Fly   124 VEQQRLVWTSPEDDTKM-CLVKGKDE-EACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYII--- 183
            ....|.|...|:...|: |:.||||. ..|.|::|::...:...|..|||.:|:|:| |:|.
Mouse    87 WPDPREVLWLPQPGQKVECVRKGKDPLTECANFVRVLQPHNRTHLLACGTGAFQPIC-TFITVGH 150

  Fly   184 -SDSNYTLEAT--KNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR----EPLQTEQ 241
             .:....|:|:  :||:..||::|.....|.....|||:|..|||.|.:.:|:|    .|.....
Mouse   151 RGEHVLRLDASSVENGRGRCPHEPSRPFASTFVGGELYTGLTADFLGREAMIFRSGGPRPALRSD 215

  Fly   242 YDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVE-FINCGKAIYSRVARVCKWDKGGPHRF 298
            .|...|:.|.||       :|....|.|||||.||... ....|....|||.|||..|.||....
Mouse   216 SDQSLLHEPRFVMAARIPDNSDRDDDKVYFFFSETVPSPDGGPGHVTISRVGRVCVNDAGGQRVL 280

  Fly   299 RNRWTSFLKSRLNCSI--PGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVC 361
            .|:|::|||:||.||:  ||....:|::::....|......|:.   :|.:|:|.|....|.|||
Mouse   281 VNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLE---VYALFSTVSAVFQGFAVC 342

  Fly   362 AFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC-----------HNDSRALPDPTLN 415
            .:.:.||.:.|.|.|..:.|....|.|. ..|||.||||.|           ...::..||..|.
Mouse   343 VYHMVDIWEVFNGPFAHRDGPQHQWGPY-GGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQ 406

  Fly   416 FIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNA 480
            |::.|.||.:.|.....:|:||:|....|..||.|| :::...| ||||||:|||.|.::| |.|
Mouse   407 FVRDHPLMFQPVRPRRGRPVLVKTHLAQRLRQIVVD-RVEAEDG-TYDVIFLGTDSGSVLK-VIA 468

  Fly   481 ESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHR 545
            .......:...||:||:.|.....||..:||            |.....|.:.:...|..:|||:
Mouse   469 LQGGGLTEPEEVVLEELQVFKVPTPITEMEI------------SVKRQTLYVGSPLGVARLQLHQ 521

  Fly   546 CHNDKITSCSECVALQDPYCAWDKIA--------GKCR------SHGAP 580
            |.... ::|:||...:|||||||..|        ||.|      .||.|
Mouse   522 CETYG-SACAECCLARDPYCAWDGTACARYRPSSGKRRFRRQDIRHGNP 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/487 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	16/47 (34%)
Sema3g	NP_001020550.1	Sema	49..522	CDD:301699	157/500 (31%)
		PSI	521..567	CDD:214655	15/46 (33%)
		Ig_Semaphorin_classIII	591..676	CDD:143279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910