Protein Alignment Sema1a and Sema6d

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_006499174.1
• Gene: Sema6d / 214968
• MGIID: 2387661
• Length: 1086
• Species: Mus musculus
• Alignment Length: 1111
• Identity: 327/1111 - (29%)
• Similarity: 477/1111 - (42%)
• Gaps: 246/1111 - (22%)

  Fly    89 GNESVVDH---FKLVTKDGNSLLIGARNTVFNLSIHDL-----VEQQRLVWTSPEDDTKMCLVKG 145
            ||||  .|   |:|:.|..::|.|..|:.|:.::::::     :..::|.|.|.:.|.:.|.:||
Mouse    50 GNES--QHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQQDRENCAMKG 112

  Fly   146 KDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTS 210
            |.::.|.|:|::.|..:...:||||||:|.|||..|.:....|..|.. :|.|.||:|.|..:.:
Mouse   113 KHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLRTLEYDGEEI-SGLARCPFDARQTNVA 176

  Fly   211 VLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETA 270
            :.||.:|||.|||||..||.:|||     ..|:|.:|||..:..|:|:.:...|::|||||||.|
Mouse   177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIA 241

  Fly   271 VEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG 334
            ||..|.|||:||||||:||.|.||..| ....||||||:|||||:|||..|||:.:||.::::
Mouse   242 VEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDII-- 304

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
            |...:.:  :.|||.|..|||||||||||::.||...|:|:||||...:|.|..|...|||.|||
Mouse   305 QINGIPT--VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

  Fly   400 GSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |.|        :..|...||.||.|||:|.|||..||....:|...:|...||.|.|.||   ::
Mouse   368 GCCAKHGLAEAYKTSIDFPDDTLAFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVD---RS 429

  Fly   457 PGG-KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVL------TKSEPIRNLEIVRT 514
            .|. :.|.|||||::.|.::|.:...|..|.:  .||::|||:..      .:||..|.   |.:
Mouse   430 AGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLN--DSVLLEEIEAYNPAKCSAESEEDRK---VVS 489

  Fly   515 MQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCAWDKIAGKC---- 574
            :|.|:      |...|.:...|.||.|.|.||  ::..||.: |:|.:||||.| ...|.|
Mouse   490 LQLDK------DHHALYVAFSSCVVRIPLSRC--ERYGSCKKSCIASRDPYCGW-LSQGVCERVT 545

  Fly   575 -------------RSHGAPRWLEENYFYQNVA-TGQ-HAACP----------------------- 601
                         .:| :|...|::..|.|.| .|. |.:.|
Mouse   546 LGMLLLTEDFFAFHNH-SPGGYEQDTEYGNTAHLGDCHESLPPSTTPDYKIFGGPTSDMEVSSSS 609

  Fly   602 ------SGKINSKDANAGEQKGFRNDMDLLDSRR--------QSKDQEIIDNIDKNFEGPQISAD 652
                  |.:|.||..:....|       |..||:        .|...:.|..|.|.... ::.:.
Mouse   610 VTTVASSPEITSKVIDTWRPK-------LTSSRKFVVQDDPNTSDFTDTISGIPKGVRW-EVQSG 666

  Fly   653 IINAQYTVETLVMAVLAGSIFSLLVGFFTG--YFC--------GRRCHKDEDDNLPYPDTEYEYF 707
            ..|....:..|:..|.|..:   |..|..|  .:|        .|:.|||.:......|:...:.
Mouse   667 ESNQMVHMNVLITCVFAAFV---LGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFA 728

  Fly   708 -----------EQRQNVNSFPS--SCRIQQEPKLLPQVEEVTYA------EPVLLPQPPPPN--- 750
                       |.:||::| |.  |..:....:|.|..:..:.|      .|.|...|.|.:
Mouse   729 KLNGLFDSPVKEYQQNIDS-PKLYSNLLTSRKELPPNTDTKSMAVDHRGQPPELAALPTPESTPV 792

  Fly   751 ---------KMHSPK----NTLRK---------PPMHQ-MHQG--PNSETLFQFQPDGYNTQQSY 790
                     |.||.|    ...||         ||.|. :..|  |::..|.....| |||
Mouse   793 LHQKTLQAMKSHSEKAHSHGASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHD-YNT---- 852

  Fly   791 RGRDNFGTLRSH------QVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVT 849
                :|....:|      |.|.....:.   |:.|..:::|::.||.|..|        :|  :.
Mouse   853 ----SFSNSNAHKAEKKLQSMDHPLTKS---SSKREHRRSVDSRNTLNDLL--------KH--LN 900

  Fly   850 QHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPS----PQESPKNCSYIYRDXLICN 910
            ...|| |:....:....|.:....||...:...|..|:...|    |...|:|......|  :..
Mouse   901 DPNSN-PKAILGEIHMAHQTLMLDPVGPMAEVPPKVPNREASLYSPPSTLPRNSPTKRVD--VPT 962

  Fly   911 TKSMPL--IQAQSTHAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGR------------TYAKS 961
            |..:|:  ::.|..:.:...|.|.....|....:|.....:|.|.:.|            .|.:.
Mouse   963 TPGVPMTSLERQRGYHKNSSQRHSISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQG 1027

  Fly   962 MPVTPVQPQSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPHL 1026
            .||: |..|..|:...||.     |:......|           .:.|.||....||.|...|..
Mouse  1028 TPVS-VHLQPSLSRQSSYT-----SNGTLPRTG-----------LKRTPSLKPDVPPKPSFVPQT 1075

  Fly  1027 IASPPL 1032
            .:..||
Mouse  1076 TSVRPL 1081

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	195/483 (40%)
		PSI	545..>579	CDD:214655	14/51 (27%)
Sema6d	XP_006499174.1	Sema	49..513	CDD:417757	196/483 (41%)
		PSI	514..>543	CDD:396154	13/31 (42%)
		PHA03247	<922..1069	CDD:223021	34/165 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4157
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850