Protein Alignment Sema1a and Sema7a

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_035482.1
• Gene: Sema7a / 20361
• MGIID: 1306826
• Length: 664
• Species: Mus musculus
• Alignment Length: 626
• Identity: 158/626 - (25%)
• Similarity: 270/626 - (43%)
• Gaps: 98/626 - (15%)

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGN-SLLIGARN 113
            :::.|||...|....:.......|::......:|.:.|...|   .|..|..:.|: |:.:|.|.
Mouse    29 LRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVDFSQPE---PHTVLFHEPGSFSVWVGGRG 90

  Fly   114 TVFNLSIHDLVEQQRLVWTSPEDDTK-MCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPM 177
            .|::.:..:  .:...|.|.....|| .|    :|::.|.|||.::.....| |.|||||:.:|.
Mouse    91 KVYHFNFPE--GKNASVRTVNIGSTKGSC----QDKQDCGNYITLLERRGNG-LLVCGTNARKPS 148

  Fly   178 CNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTV--ADFSGSDPIIYREPLQTE 240
            | ..:::||.........|.|  |:.|..||..:...:|:|| |:  .:::|..|...|...::|
Mouse   149 C-WNLVNDSVVMSLGEMKGYA--PFSPDENSLVLFEGDEVYS-TIRKQEYNGKIPRFRRIRGESE 209

  Fly   241 QY--DSLSLNAPNFVSSF------TQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHR 297
            .|  |::..| |.|:.:.      ...|.:|:||||...:.........||||::|:.|:||...
Mouse   210 LYTSDTVMQN-PQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESS 273

  Fly   298 FR-NRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVC 361
            .. ::|.:|||:.|.||...... .||.:|... |:....|......:||||:.|.|.   ||||
Mouse   274 LSVSKWNTFLKAMLVCSDAATNR-NFNRLQDVF-LLPDPSGQWRDTRVYGVFSNPWNY---SAVC 333

  Fly   362 AFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLMDEN 426
            .::|.||...|          .::.|...:..:|:||||.|....:.:|..|.....:|..:.:.
Mouse   334 VYSLGDIDRVF----------RTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQR 388

  Fly   427 V--------PAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESA 483
            |        |.|.|:         |.:.::.|. :::...|:|:.|:::.||.|.|.|.|
Mouse   389 VEPMGPLKTPLFHSK---------YHYQKVVVH-RMQASNGETFHVLYLTTDRGTIHKVV----- 438

  Fly   484 DSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHN 548
            :|.|:..|.|...:::    :|......::.:..|.      |..||.:.:..:|..:.|..|
Mouse   439 ESGDQDHSFVFNIMEI----QPFHRAAAIQAISLDA------DRRKLYVTSQWEVSQVPLDMC-- 491

  Fly   549 DKITS--CSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ-HAACPSGKINSKDA 610
             ::.|  |..|:..:||||.||:  .:|.|    .:..:....|::...: |..||    |.|..
Mouse   492 -EVYSGGCHGCLMSRDPYCGWDQ--DRCVS----IYSSQRSVLQSINPAEPHRECP----NPKPD 545

  Fly   611 NAGEQKG--FRNDMDLLDSRRQSKDQEII----DNIDKNFE 645
            .|..||.  .||....|....:|:....:    :|::::.|
Mouse   546 EAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCE 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	124/475 (26%)
		PSI	545..>579	CDD:214655	12/35 (34%)
Sema7a	NP_035482.1	Sema_7A	70..489	CDD:200504	123/473 (26%)
		Cell attachment site. /evidence=ECO:0000255	265..267		0/1 (0%)
		Interaction with integrins. /evidence=ECO:0000250	265..267		0/1 (0%)
		PSI	491..>518	CDD:279745	11/31 (35%)
		Ig	547..617	CDD:299845	9/40 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000