DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema6c

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001258953.1	Gene:	Sema6c / 20360	MGIID:	1338032	Length:	963	Species:	Mus musculus

Alignment Length:	1111	Identity:	324/1111 - (29%)
Similarity:	447/1111 - (40%)	Gaps:	281/1111 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGN----QSAWQENIRPKLYVEL----------GPEDVLKFVGNESVVDHFKLVTKDG 104
            |||.:|::.:    |:|:.::..|.|..:|          |.||  ..|..|..:|..:.:|.:
Mouse    10 LLLLLLLLSSLPQAQAAFPQDPTPLLTSDLQGASPSSWFRGLED--DAVAAELGLDFQRFLTLN- 71

  Fly   105 NSLLIGARNTVFNLSI------HDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSP 163
            .:||:.||:.||:..:      ..||..:.|.|.|  .|.:.|.|:||..:.|.||||::|..:.
Mouse    72 RTLLVAARDHVFSFDLQAQEEGEGLVPNKFLTWRS--QDMENCAVRGKLTDECYNYIRVLVPWNS 134

  Fly   164 GRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGS 228
            ..|..||||||.|||.:|.|:......|.. :|||.||:|...::.::.|:..|||.|.|||..|
Mouse   135 QTLLACGTNSFSPMCRSYGITSLQQEGEEL-SGQARCPFDATQSTVAIFAEGSLYSATAADFQAS 198

  Fly   229 DPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVC 288
            |.::||.     ||::.:|||..|..|:||.:...|:.|||||||.:||....|:..:|||||||
Mouse   199 DAVVYRSLGPQPPLRSAKYDSKWLREPHFVYALEHGEHVYFFFREVSVEDARLGRVQFSRVARVC 263

  Fly   289 KWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPS 352
            |.|.|| |......||||||.|||||:|||..|||:.:||    :.|.........::|||.|.:
Mouse   264 KRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFDVLQS----LTGPVNLHGRSALFGVFTTQT 324

  Fly   353 NSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRAL 409
            |||||||||||.|.||...|||:||||..::..|.||:..|||.||||||        .:.|:.|
Mouse   325 NSIPGSAVCAFYLDDIERGFEGKFKEQRSLDGAWTPVSEDKVPSPRPGSCAGVGAAASFSSSQDL 389

  Fly   410 PDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKI 474
            ||..|.|||.|.|:|..||....||:|..||... .||:|||.........|  |:|:|::.|.:
Mouse   390 PDDVLLFIKAHPLLDPAVPPATHQPLLTLTSRAL-LTQVAVDGMAGPHRNTT--VLFLGSNDGTV 451

  Fly   475 IKSV--NAESADSADKVTSVVIEEIDVLT------KSEP-----IRNLEIVRTMQYDQPKDGSYD 526
            :|.:  ..:|..|    ..:|:||||..:      |..|     |..||:            ..:
Mouse   452 LKVLPPGGQSLGS----EPIVLEEIDAYSHARCSGKRSPRAARRIIGLEL------------DTE 500

  Fly   527 DGKLIIVTDSQVVAIQLHRC--HNDKITSCS-ECVALQDPYCAWDKIAGKCRSHGAPRWLEENYF 588
            ..:|.:.....:|.:.|.||  |.    :|. .|:|..||||.|.:..| |.|...|...:.: .
Mouse   501 GHRLFVAFPGCIVYLSLSRCARHG----ACQRSCLASLDPYCGWHRSRG-CMSIRGPGGTDVD-L 559

  Fly   589 YQNVATGQHAACPSGKINSK------------------------DANAGEQ--------KGFRND 621
            ..|..:.:|..|..|...|:                        ||..|.|        :|.|.|
Mouse   560 TGNQESTEHGDCQDGATGSQSGPGDSAYVLLGPGPSPETPSSPSDAQQGPQSSTLGAHTQGVRRD 624

  Fly   622 MDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFC- 685
            :....:.|             :...|.:.|.:..|         ..|..|:..|||.      |
Mouse   625 LSPASASR-------------SIPIPLLLACVAAA---------FALGASVSGLLVS------CA 661

  Fly   686 ----GRRCHKD-EDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQ 745
                .||..|| |...||.|             .|..|..|:....                 |:
Mouse   662 CRRANRRRSKDIETPGLPRP-------------LSLRSLARLHGGG-----------------PE 696

  Fly   746 PPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGD--- 807
            ||||     ||:       ....|.|...|.|...|||.:..:       ...|.:.:...:
Mouse   697 PPPP-----PKD-------GDAAQTPQLYTTFLPPPDGGSPPE-------LACLPTPETTPELPV 742

  Fly   808 NYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPR----------HGIVTQHRSNSPQQQQQ- 861
            .:.|..|.....       |.|..|.|.|..|  |||          ..:|.......|.|..:
Mouse   743 KHLRASGGPWEW-------NQNGNNASEGPGR--PPRGCSGAGGPAPRVLVRPPPPGCPGQAVEV 798

  Fly   862 ----------QSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRDXLICNTKSMPL 916
                      ...|| ...||.|:.|...:| .||:|.|.        :.::.|
Mouse   799 TTLEELLRYLHGPQP-PRKGSEPLASAPFTS-RPPASEPG--------ASLFVD----------- 842

  Fly   917 IQAQSTHAQPHPQSHPHPL----PPPGP-TTPPAQP--RARSPMIGRTYAKSMPV-TPVQPQSPL 973
                   :.|.|:....||    ||.|. ..|..:|  .|.:|.:|...::.:|. |...|...|
Mouse   843 -------SSPMPRDGVPPLRLDVPPEGKRAAPSGRPALSAPAPRLGVGGSRRLPFPTHRAPPGLL 900

  Fly   974 AETPS--YELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPHLIASPPLPPPR 1036
            ...||  ...|.........:.|..:..........|..|  .::|.||      :||||.|.|.
Mouse   901 TRVPSGGPARYSGGPGRHLLYLGRPEGHRGRSLKRVDVKS--PLSPKPP------LASPPQPAPH 957

  Fly  1037 --RFRF 1040
              .|.|
Mouse   958 GGHFNF 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	189/487 (39%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/36 (39%)
Sema6c	NP_001258953.1	Sema	54..518	CDD:387663	189/490 (39%)
		PSI	519..>540	CDD:214655	10/24 (42%)
		PHA03247	<714..956	CDD:223021	62/293 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860