DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema6b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001123928.1	Gene:	Sema6b / 20359	MGIID:	1202889	Length:	886	Species:	Mus musculus

Alignment Length:	1065	Identity:	296/1065 - (27%)
Similarity:	445/1065 - (41%)	Gaps:	272/1065 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLK----FVGN--------ESVVD-HFKLVT 101
            :..||||.:.|  ....:.|...|   :.:.|.|.|.    |||:        |...| :.:.|.
Mouse    13 LSFFLLLLLGV--TYGLFPEEPPP---LSVAPRDYLSHYPVFVGSGPGRLTAAEGAEDLNIQRVL 72

  Fly   102 KDGNSLLIGARNTVFNLSIH-----DLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVP 161
            :...:|.||.|:.::.:.:.     :|..|::|.|.|...|..:|.:|||.|..|:|:::::::.
Mouse    73 RVNRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLR 137

  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226
            ....|||||:|:|.|:|..|.: |:...|..:.:|.|.|||||:|.:.::.:|..|::.||.||.
Mouse   138 DESTLFVCGSNAFNPICANYSM-DTLQLLGDSISGMARCPYDPKHANVALFSDGMLFTATVTDFL 201

  Fly   227 GSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVAR 286
            ..|.:|||.     .|:|.::||.....|.||.:...|..|||||||.|:||....|.:.|||||
Mouse   202 AIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVAR 266

  Fly   287 VCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK-LIYGVFN 349
            |||.|.|| |.....:||||||:|||||:|||..||||.:|:.:.:|     |:..: :|..||:
Mouse   267 VCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVV-----SLGGRPVILAVFS 326

  Fly   350 TPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC------HNDSRA 408
            ||||||||||||||.:..:|..|||:|:||....|.|.||...:||.||||.|      :|.|.|
Mouse   327 TPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSA 391

  Fly   409 LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGK 473
            |||..|||:|||.||||.||:....|.:|||...::.|::|||......|.:|  ::|:|::.|.
Mouse   392 LPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAVDVGAGPWGNQT--IVFLGSEAGT 454

  Fly   474 IIK-SVNAESADSADKVTSVVIEEIDVLTK------------SEPIRNLEIVRTMQYDQPKDGSY 525
            ::| .|...::.|.....|:.:||.:....            .:.:.:||:          |.:
Mouse   455 VLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLEL----------DAA- 508

  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKITSC-SECVALQDPYCAWDKIAGKC--RSHGAPRWLEENY 587
             .|.|:......||.:.:.||  ...:.| ..|:..|||||.|.. .|.|  ...|.....|:
Mouse   509 -SGGLLAAFPRCVVRVPVARC--QLYSGCMKNCIGSQDPYCGWAP-DGSCIFLRPGTSATFEQ-- 567

  Fly   588 FYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISAD 652
                                 |.:.....|..:...||  |....|..               |.
Mouse   568 ---------------------DVSGASTSGLGDCTGLL--RASLSDDR---------------AG 594

  Fly   653 IINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR------CHKDEDDNLPYPDTEYEYFEQRQ 711
            :::....|.:.|.|.:.|::.|   ||..|:|.|.|      ..||::..|.:..:|
Mouse   595 LVSVNLLVTSSVAAFVVGAVVS---GFSVGWFVGLRERRELARRKDKEAILAHGGSE-------- 648

  Fly   712 NVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSP--KNTLRKPPMHQMHQGPNS- 773
               :..|..|:.:.....|.........|     ..||..:.:|  :|...|..:  :|.||:.
Mouse   649 ---AVLSVSRLGERRGTGPGGRGGAGGGP-----GGPPEALLAPLMQNGWTKAAL--LHGGPHDL 703

  Fly   774 ETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRA 838
            :|                     |.|.:.:             .|...:|.:...:....:|| :
Mouse   704 DT---------------------GLLPTPE-------------QTPLPQKRLPTPHPHAHALG-S 733

  Fly   839 RRQPPRHGIVTQHRSNS-----PQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQE---S 895
            |.....|.:::...|.|     |.:..:|.|.|                     :.|.|:.   :
Mouse   734 RAWDHSHALLSASASTSLLLLAPARASEQPQVP---------------------AEPGPESRLCA 777

  Fly   896 PKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQ---SHP-HPLPP------PGPTTPPAQPRAR 950
            |::|.       ..:....||    :.||.|..:   |.| .||.|      |||.:|||....|
Mouse   778 PRSCR-------ASHPGDFPL----TPHASPDRRRVVSAPTGPLDPSVGDGLPGPWSPPATSSLR 831

  Fly   951 SPMIGRTYAKSMPVTPVQPQSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMI 1015
            .|               .|..|    |:..|...|    ||:.|:..........|
Mouse   832 RP---------------GPHGP----PTAALRRTH----TFNSGEARPGGHRPRRH--------- 864

  Fly  1016 TPPPPYDTPHLI-------ASPPLP 1033
               ||.|:.||:       .:||:|
Mouse   865 ---PPADSTHLLPCGTGERTAPPVP 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	181/486 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/36 (33%)
Sema6b	NP_001123928.1	Sema_6B	58..526	CDD:200528	181/487 (37%)
		PSI	527..573	CDD:214655	15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..677		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..731		8/67 (12%)
		PHA03269	708..>875	CDD:165527	49/247 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..886		41/191 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	317	1.000	Domainoid score	I1262
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8703
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820