DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema5a

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_033180.2	Gene:	Sema5a / 20356	MGIID:	107556	Length:	1074	Species:	Mus musculus

Alignment Length:	955	Identity:	290/955 - (30%)
Similarity:	410/955 - (42%)	Gaps:	213/955 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 YVELGPEDVLKFVGNESVVDHFKLVTKDG-NSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTK 139
            |.|:||  .|:....|:.||..:|....| ..|::||||.:|.|.:.||...|.:.|...|...|
Mouse    40 YKEIGP--WLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLELEDLSLIQAVEWECDEATKK 102

  Fly   140 MCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYT-LEATKNGQAVCPYD 203
            .|..|||.:|.||||||:::| ...|||.||||:|.|:|.  |.|.||.| :....:|.|.|||.
Mouse   103 ACYSKGKSKEECQNYIRVLLV-GGDRLFTCGTNAFTPVCT--IRSLSNLTEIHDQISGMARCPYS 164

  Fly   204 PRHNSTSVL-ADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFV 262
            |:||||::| |..|||:.|..||.|.||.|||.     ||:|.||:|..||.||||||:..|:|.
Mouse   165 PQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPNFVSSYDIGNFT 229

  Fly   263 YFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQS 327
            ||||||.|||. :|||.::||.|||||.|.||.....:.||:|:|:|||||.||:.|||:||:|.
Mouse   230 YFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQG 293

  Fly   328 ASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNA 392
            ...|.|       ..||||:|.|..|||..||||.|.|..|:..|.|.||.|....|.|||
Mouse   294 TFFLPE-------LDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP---- 347

  Fly   393 KVPDPRPG-SC---------HNDSRALPDPTLNFIKTHSLMD--ENVPAFFSQPILVRTSTIYRF 445
             .|:|.|. .|         :...|.|.| ...||..|.::.  ..||:|....        .||
Mouse   348 -YPNPNPNFQCGTMDQGLYVNLTERNLQD-AQKFILMHEVVQPVTTVPSFMEDN--------SRF 402

  Fly   446 TQIAVDAQIKTPGGKT-YDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVL--TKSEPIR 507
            :.:|||.   ..|.:| ..:|::.||:| .||.|.|..:.|:.   |.::|||::.  .:|||||
Mouse   403 SHLAVDV---VQGRETLVHIIYLATDYG-TIKKVRAPLSQSSG---SCLLEEIELFPERRSEPIR 460

  Fly   508 NLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAG 572
            :|:|:            :....|.:.....|..|.|.|||..:..|.  |:..|||||.||.:..
Mouse   461 SLQIL------------HSQSVLFVGLQEHVAKIPLKRCHFHQTRSA--CIGAQDPYCGWDAVMK 511

  Fly   573 KCRSHGAPRWLEEN----YFYQNVATGQHAACPSGKINSKDANAGEQKGF----RNDMDLLDS-- 627
            ||.|      |||:    .:.|::.|     ||:..: :.|.:.|....:    ..|...:.|
Mouse   512 KCTS------LEESLSMTQWDQSIPT-----CPTRNL-TVDGSFGPWSPWTPCTHTDGTAVGSCL 564

  Fly   628 -RRQSKDQEIIDNIDKNFEGPQISADIINAQ----YTVET--LVMAVLAGSIFS----------- 674
             |.:|.|...........|||::  :|.|..    :|..|  ...:...|..|.
Mouse   565 CRSRSCDSPAPQCGGWQCEGPRM--EITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTP 627

  Fly   675 -----LLVG------------------FFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSF 716
                 :.||                  |:||:....||.......:.         .:|:...:.
Mouse   628 RHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQ---------ARRRTCENG 683

  Fly   717 P--SSCRIQQEP---KLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETL 776
            |  :.|.::.:|   ...|::::.|       |..|             ..|::....|.:.|..
Mouse   684 PDCAGCNVEYQPCNTNACPELKKTT-------PWTP-------------WTPVNISDNGGHYEQR 728

  Fly   777 FQFQ-----PD-------GYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTN 829
            |::.     ||       ....:..|...|......:..:.||..|.|      |.....||...
Mouse   729 FRYTCKARLPDPNLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAG------RYSAHTVNGAW 787

  Fly   830 TRNRSLGRARRQPPRHGIVTQHR-SNSPQQQ-------------QQQSQQPHSSSGSSPVMSNSS 880
            :...|..:..|...| ||..:.| .|:|:.:             |:.:..|....|.....|:.|
Mouse   788 SAWTSWSQCSRDCSR-GIRNRKRVCNNPEPKFGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWS 851

  Fly   881 SSPAP----------PSSSPSPQESPKNCSYIYRDXLICNTKSMP 915
            ...|.          ..|:|:|......|..::.: .:|||::.|
Mouse   852 KCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQTCP 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	195/477 (41%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	15/33 (45%)
Sema5a	NP_033180.2	Sema_5A	50..485	CDD:200524	194/478 (41%)
		PSI	486..533	CDD:396154	20/59 (34%)
		TSP1	544..595	CDD:214559	11/52 (21%)
		TSP1	598..651	CDD:214559	6/52 (12%)
		TSP1	656..702	CDD:214559	8/54 (15%)
		TSP1	787..839	CDD:214559	10/52 (19%)
		TSP1	853..896	CDD:214559	8/42 (19%)
		TSP1	899..940	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810