DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema4a

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_006501250.1	Gene:	Sema4a / 20351	MGIID:	107560	Length:	798	Species:	Mus musculus

Alignment Length:	676	Identity:	202/676 - (29%)
Similarity:	302/676 - (44%)	Gaps:	124/676 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LVTKDGNSLLIGARNTVFNLSIHD--LVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMV 159
            |::.|||:|.:|||..|..|:|.:  :...:.:: |.:.|.....|..|.|..|. |.|:||::|
Mouse   106 LLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLV 170

  Fly   160 VPSPGRLFVCGTNSFRPMCNTYIISDS---NYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGT 221
            ..:...|:.|||.:|.|.|....:.||   ...::...:|:...|:||.|..|:||.|..|||||
Mouse   171 SYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGT 235

  Fly   222 VADFSGSDPIIYR----EP-LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIY 281
            :.:|.||:||:.|    :| |:|:.:........:||::......|||||.|||.||....:...
Mouse   236 MNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYI 300

  Fly   282 SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYG 346
            ||||:|||.|.||....:.:||:|||::|.|:.||..|  ||.|:.|..|   ...|.|...||.
Mouse   301 SRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLP--FNIIRHAVLL---PADSPSVSRIYA 360

  Fly   347 VFNTPSNSIPG---SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRA 408
            || |....:.|   ||||||:|.||...|:|::||.....|.|.....::| .||||||.....:
Mouse   361 VF-TSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEV-SPRPGSCSMGPSS 423

  Fly   409 LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGK 473
              |..|.|:|.|.||||:|   ...|:||::...|  |::||:: .:...|.::.|:::||..|.
Mouse   424 --DKALTFMKDHFLMDEHV---VGTPLLVKSGVEY--TRLAVES-ARGLDGSSHVVMYLGTSTGS 480

  Fly   474 IIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGS----YDDGKLIIVT 534
            :.|:|..:.:      ::.::|||.:...|||:|||::.       |..|:    :..|
Mouse   481 LHKAVVPQDS------SAYLVEEIQLSPDSEPVRNLQLA-------PAQGAVFAGFSGG------ 526

  Fly   535 DSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-------------RSHGAPRWLEEN 586
                 ..::.|.:.....||.:||..:||:||||..:..|             ...|.|.|:
Mouse   527 -----IWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWV--- 583

  Fly   587 YFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEI-----IDNIDKNFEG 646
                 ...|..|..|                          ||||..|.|     :.|.......
Mouse   584 -----CTRGPMARSP--------------------------RRQSPPQLIKEVLTVPNSILELPC 617

  Fly   647 PQISADIINAQY-------TVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEY 704
            |.:||   .|.|       .:......|..||:..|......|.:   :|...| :...||...|
Mouse   618 PHLSA---LASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLY---QCVATE-NGYSYPVVSY 675

  Fly   705 EYFEQRQNVNSFPSSCRIQQEPKLLP 730
            ....|.|.:...|....:.:|...:|
Mouse   676 WVDSQDQPLALDPELAGVPRERVQVP 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	157/465 (34%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/46 (26%)
Sema4a	XP_006501250.1	Sema	93..533	CDD:387663	157/465 (34%)
		PSI	534..578	CDD:214655	11/43 (26%)
		Ig	603..675	CDD:386229	15/78 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910