DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema3e

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_035478.2	Gene:	Sema3e / 20349	MGIID:	1340034	Length:	775	Species:	Mus musculus

Alignment Length:	740	Identity:	200/740 - (27%)
Similarity:	327/740 - (44%)	Gaps:	139/740 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 HFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQR-LVWTSPEDDTKMCLVKGKDEEACQNYIRIMV 159
            |..|:.:....|.:|.|:.|::|::..:.:..| :.|.|.....:.|::||||...|.||||::.
Mouse    59 HTMLLDEYQERLFVGGRDLVYSLNLERVSDGYREIYWPSTAVKVEECIMKGKDANECANYIRVLH 123

  Fly   160 VPSPGRLFVCGTNSFRPMCNTYIISDSN----YTLEA--TKNGQAVCPYDPRHNSTSVLADNELY 218
            ..:...|..|.|.:|.|.|....:...:    :.||:  ::.|:..||:||..:..|.|..|||:
Mouse   124 HYNRTHLLTCATGAFDPHCAFIRVGHHSEEPLFHLESHRSERGRGRCPFDPNSSFVSTLVGNELF 188

  Fly   219 SGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGD-------FVYFFFRETAV 271
            :|..:|:.|.|..|:|.     .::||..|...|..|.||.|:...|       .:||||.|.|:
Mouse   189 AGLYSDYWGRDSAIFRSMGKLGHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKMYFFFTEKAL 253

  Fly   272 EFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEG 334
            |..|....||:||.|:|..|.||.....|:|::|||:||.||:||  ....||:|::....|
Mouse   254 EAENNAHTIYTRVGRLCVNDMGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLL--- 315

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
            ......:.:|:|:|||.||...|.|||.:.:..|.:.|.|.:..:.|...:| .:...|||.|||
Mouse   316 PTRDPKNPVIFGLFNTTSNIFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHW-SLYEGKVPYPRP 379

  Fly   400 GSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |||        :..::..||..:.|.:.|.||.:.:.....:||||:|...|...|:||| :::.
Mouse   380 GSCASKVNGGKYGTTKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAVD-RVEA 443

  Fly   457 PGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPK 521
            ..|: |||:|:|||.|.::|.:...:.:: :.:..|::||:.:.....||.::||....|
Mouse   444 EDGQ-YDVLFIGTDTGIVLKVITIYNQET-EWMEEVILEELQIFKDPAPIISMEISSKRQ----- 501

  Fly   522 DGSYDDGKLIIVTDSQVVAIQLHRCHNDKI-TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEE 585
                   :|.|.:.|.|..::.|.|  |.. ::|::|...:|||||||.|:  |          .
Mouse   502 -------QLYIGSASAVAQVRFHHC--DMYGSACADCCLARDPYCAWDGIS--C----------S 545

  Fly   586 NYFYQNVATGQHAACPSGKINSKDANAGEQ-------------------KGFRNDMDLLDSRRQS 631
            .|:    .||.||.....:.:.:..||.:|                   .|..::..||:...:|
Mouse   546 RYY----PTGAHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDRTEERLAYGIESNSTLLECTPRS 606

  Fly   632 KDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-YFCG--------- 686
            ...::|..:.|       ..|:...:...:..|:.:..|.:|..:.....| |||.
Mouse   607 LQAKVIWFVQK-------GRDVRKEEVKTDDRVVKMDLGLLFLRVRKSDAGTYFCQTVEHNFVHT 664

  Fly   687 -RRC--------------HKDEDD----NLPYPDTE---------YEYFEQRQNVNSFPSS---- 719
             |:.              |||.::    .:|.|...         |:.|.|....::|...
Mouse   665 VRKITLEVVEEHKVEGMFHKDHEEERHHKMPCPPLSGMSQGTKPWYKEFLQLIGYSNFQRVEEYC 729

  Fly   720 ----CRIQQEPKLLPQVEEVTYAEP 740
                |..::..||.....:..||.|
Mouse   730 EKVWCTDKKRKKLKMSPSKWKYANP 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	149/478 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/34 (38%)
Sema3e	NP_035478.2	Sema_3E	49..519	CDD:200514	149/478 (31%)
		PSI	518..566	CDD:214655	18/65 (28%)
		Ig_Semaphorin_classIII	585..675	CDD:143279	15/96 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910