DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and Sema3a

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001230001.1	Gene:	Sema3a / 20346	MGIID:	107558	Length:	772	Species:	Mus musculus

Alignment Length:	861	Identity:	235/861 - (27%)
Similarity:	387/861 - (44%)	Gaps:	203/861 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GWMQ----VFLLLTVLVIGNQSAWQENIRPKL---YVE-LGPEDVLKFVG--NESVVDHFKLVTK 102
            ||..    :|..:.:....|.:..:.|: |:|   |.| |...:|:.|.|  |.|.. |..|:.:
Mouse     2 GWFTGIACLFWGVLLTARANYANGKNNV-PRLKLSYKEMLESNNVITFNGLANSSSY-HTFLLDE 64

  Fly   103 DGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRL 166
            :.:.|.:||::.:|:.::.::.:.|::||.........|...||| .:.|.|:|:::...:...|
Mouse    65 ERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHL 129

  Fly   167 FVCGTNSFRPMCNTYI------------ISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYS 219
            :.|||.:|.|:| |||            :.||::     :||:...||||:..:.|:|.|.||||
Mouse   130 YACGTGAFHPIC-TYIEVGHHPEDNIFKLQDSHF-----ENGRGKSPYDPKLLTASLLIDGELYS 188

  Fly   220 GTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETAVE 272
            ||.|||.|.|..|:|     .|::|||:||..||.|.|:|:.       .:.|.|||||||.|::
Mouse   189 GTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAID 253

  Fly   273 FINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEGQ 335
            ..:.|||.::|:.::||.|.||.....|:||:|||:||.||:||  ....:|:|:|...
Mouse   254 GEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVF------ 312

  Fly   336 YGSMSSK-----LIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVP 395
              .|:||     ::||||.|.||...|||||.:::.|:...|.|.:..:.|.|..|:|. ..:||
Mouse   313 --LMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPY-QGRVP 374

  Fly   396 DPRPGSC-------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQ 453
            .||||:|       .:.::.|||..:.|.::|..|...|....::||:::|...|:||||.|| :
Mouse   375 YPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVD-R 438

  Fly   454 IKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYD 518
            :....|: |||:|:|||.|.::|.|:.......| :..|::||:.|..:...|..:|:....|
Mouse   439 VDAEDGQ-YDVMFIGTDVGTVLKVVSVPKETWHD-LEEVLLEEMTVFREPTTISAMELSTKQQ-- 499

  Fly   519 QPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCR-------- 575
                      :|.|.:.:.|..:.|||| :....:|:||...:|||||||  ...|.
Mouse   500 ----------QLYIGSTAGVAQLPLHRC-DIYGKACAECCLARDPYCAWD--GSSCSRYFPTAKR 551

  Fly   576 -----------------------SHGAPRWLEENYFY--QNVATGQHAACPSGKI--------NS 607
                                   :|..|. |||...|  :|.:|....:..|.:.        .:
Mouse   552 RTRRQDIRNGDPLTHCSDLQHHDNHHGPS-LEERIIYGVENSSTFLECSPKSQRALVYWQFQRRN 615

  Fly   608 KDANAGEQKG---FRNDMDLLDSRRQSKD--QEIIDNIDKNFEGP--QISADIINAQYTVETLVM 665
            :|.....:.|   .|.:..||....|.||  ..:...::..|...  :::.::|:.::..|.|
Mouse   616 EDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELL-- 678

  Fly   666 AVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLP 730
                                    |||:|.:                      ..:|::....:.
Mouse   679 ------------------------HKDDDGD----------------------GSKIKEMSSSMT 697

  Fly   731 QVEEVTYAEPVLLPQPPPPNKMHS--------PKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQ 787
            ..::|.|.:.:.|...|..|.|..        .:...|:.|.|.  ||.:::        ..:.|
Mouse   698 PSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHS--QGSSNK--------WKHMQ 752

  Fly   788 QSYRGRDNFGTLRSHQ 803
            :|.:||:.    |:|:
Mouse   753 ESKKGRNR----RTHE 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	165/493 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/64 (22%)
Sema3a	NP_001230001.1	Sema_3A	26..518	CDD:200510	177/524 (34%)
		PSI	516..>552	CDD:214655	13/38 (34%)
		Ig_Sema3	580..671	CDD:409455	17/91 (19%)
		Ig strand B	594..598	CDD:409455	1/3 (33%)
		Ig strand C	606..610	CDD:409455	0/3 (0%)
		Ig strand E	633..637	CDD:409455	1/3 (33%)
		Ig strand F	647..652	CDD:409455	0/4 (0%)
		Ig strand G	664..667	CDD:409455	0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..772		11/50 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910