Protein Alignment Sema1a and plx-2

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_001364609.1
• Gene: plx-2 / 175101
• WormBaseID: WBGene00004048
• Length: 1785
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 126/566 - (22%)
• Similarity: 216/566 - (38%)
• Gaps: 155/566 - (27%)

  Fly    52 VFLLLT--VLVIGNQSAWQ-ENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARN 113
            |||||.  .|....|..:: |.::.||:         .|.|:   :|.| :|::|..::.:.:.|
 Worm     6 VFLLLISHFLRAVTQPPFETEGVKQKLF---------HFSGH---IDDF-IVSRDQQTIYVASLN 57

  Fly   114 TVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKG----KDEEACQNYIR---IMVVPSPGRLFVCGT 171
            .:.:|||.:...|.. |...|..|:..|...|    ||.......:|   :.::|: .::..||:
 Worm    58 RLTSLSISNFSIQHE-VSLGPVQDSPWCSADGKSCLKDNRPFPTDVRTKILQILPT-NQILQCGS 120

  Fly   172 NSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREP 236
            ... ..|:|:   :|..:| .|::..||....|..::.|.:.||.|.  ..|..:...|  ||:|
 Worm   121 VKL-GSCSTF---NSKLSL-ITESTIAVAANSPDASTVSKIIDNRLI--VAASATKESP--YRDP 176

  Fly   237 -----------LQTEQYDSLS-----------LNAPNFVSSFTQGDFVYFFFRETAVEFINCGKA 279
                       |..|....|.           .||..|:.:||...||:.....|..|   ....
 Worm   177 FPAVAIRNLPGLNVENAGDLEGEAAVFLRAAYKNAFKFLYTFTHQHFVFVVAMVTPRE---SRLP 238

  Fly   280 IYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGD----YPFYFNEIQSASNLVEGQYGSMS 340
            :.:|:.|.|:.|        .::.|:.:..|.|.  |:    |||....|||...|:..
 Worm   239 MTTRLIRFCRND--------TKFESYSEIELQCR--GEDNTNYPFLNAIIQSYDKLIAS------ 287

  Fly   341 SKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHND 405
                   |:|.|.| |.|::|.|::|.:..||             |..|:..     |.|:   |
 Worm   288 -------FSTSSTS-PKSSICVFSMQKVKLTF-------------WYNVDRC-----RSGT---D 323

  Fly   406 SRALPD---PTLNFIKTHSLMDEN-----------VPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |..||.   .|....|.|..:||:           :....::.|:.:.:::     :|||.:
 Worm   324 SIRLPHIGRDTKCVNKAHIPLDEDSCELGVGGSIELVEMSTKDIMGKVTSL-----MAVDQK--- 380

  Fly   457 PGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPK 521
                   .||.||...:|:..       ..|:..|..:||.......:.....|:.:.:::
 Worm   381 -------AIFAGTTTSQIVMF-------KWDEHHSNQLEEYGRKEVGDGRTGSEVSKMVKF---- 427

  Fly   522 DGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAW 567
             |.:    :|:.....::..:|..|.:.  :||:||:...||.|.|
 Worm   428 -GDF----VIVQMPYGIILEELSTCSHH--SSCTECLVSVDPLCQW 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	105/501 (21%)
		PSI	545..>579	CDD:214655	9/23 (39%)
plx-2	NP_001364609.1	Sema	38..415	CDD:417757	101/461 (22%)
		PSI	447..488	CDD:214655	9/22 (41%)
		TIG_plexin	496..>546	CDD:407808
		PSI	577..>615	CDD:396154
		IPT_plexin_repeat1	750..839	CDD:238585
		IPT_plexin_repeat2	841..925	CDD:238584
		IPT	928..1017	CDD:417750
		Plexin_cytopl	1213..1744	CDD:400574

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910