DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and mab-20

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_490875.1	Gene:	mab-20 / 171727	WormBaseID:	WBGene00003111	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	677	Identity:	174/677 - (25%)
Similarity:	284/677 - (41%)	Gaps:	160/677 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVD----HFK--LVTKDGNSLL 108
            |:.||:.:|:.|...|....||:                .:.:..|    .|:  |:.....:|.
Worm     1 MRNFLVFSVIFIAYNSCEAANIQ----------------ADNTFADPNIGEFRELLIDPKAGALF 49

  Fly   109 IGARNTVFNL---SIHDLVE----QQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSP-GR 165
            :|:...:|.|   :|:|..|    :::||.:..|:..  |.....||..|:...|.:...:. ..
Worm    50 VGSEGAIFRLWAYNINDTGENVFAKKQLVLSESEESE--CRSTASDERLCRPSTRFLAFTNNLDS 112

  Fly   166 LFVCGTNSFRP---MCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADN-------ELYSG 220
            ::||.:...||   :.::..:.|.    :..:....:|..||..|.|:|:.|:       .:|||
Worm   113 IYVCSSVGMRPEIRVLDSLSLRDQ----QEPRTEIGICVVDPTFNFTAVVVDSGNPEDATSVYSG 173

  Fly   221 TVADFSGSDPIIYREPL-----------QTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFI 274
            ......|.:.:|||.||           :|...|:..||.|.||.||..|..|:|||||.|.:..
Worm   174 IRTGMGGENHLIYRPPLTKNGKQLHASIRTIYSDNKWLNEPQFVGSFDVGQHVFFFFREIAHDNS 238

  Fly   275 NCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSM 339
            ...:.::||||||||.|.||.:..|..||||:|:|||||:..::||||:.|||...:  .::|
Worm   239 FGERIVHSRVARVCKKDIGGRNVLRQVWTSFVKARLNCSVSANFPFYFDHIQSVKRV--DKHG-- 299

  Fly   340 SSKLIYGVFNTPSNSIPGSAVCAFALQDI----------ADTFEGQFKEQTGINSNWLPVNNAKV 394
             ....|..|:|...:...||:|.|.|..|          .:|..|||.           |...::
Worm   300 -ETYFYATFSTSETAFTSSAICMFQLSSINHLLDTGLLMEETANGQFS-----------VTADEI 352

  Fly   395 PDPRPGSCHNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGG 459
            |..|||:|..:|.::.|..|:|.|||.|:.:::..  ..|||.....:  ||.|.||   :.|
Worm   353 PAHRPGTCSQNSHSISDTDLHFAKTHLLVSDSISG--GTPILPLRDHV--FTHIVVD---QLP-- 408

  Fly   460 KTYDVIFVGTDHGKIIKSVNAESADSAD----KVT---------SVVIEEIDVLTKSEPIRNLEI 511
             ..:|||               :.|||:    |::         |.:|||..:...:..|.::.:
Worm   409 -NQNVIF---------------AFDSANRRVWKISHWKEGNEWKSNLIEEKSLKIAASRINDVAL 457

  Fly   512 VRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC-- 574
            :       |.:..:      :.:.:.|....:.||...  .||:.|..  ||||:|:.:..||
Worm   458 L-------PAEFFF------VTSGAGVSQFSVARCSEQ--PSCALCSL--DPYCSWNAVNSKCSL 505

  Fly   575 ------RSHGAPRWLEENYFYQNVATGQHAACPS-GKINSKDANAGE---QKGFRNDMDLLDSRR 629
                  :|.|   |:..::     |......|.: .|:..||...|:   ..|.:|.:...|.|.
Worm   506 KTKTNEKSVG---WISSSW-----AGRISPECSAVEKLTVKDVYLGDGLRLVGAKNGVWQKDGRS 562

  Fly   630 QSKDQEIIDNIDKNFEGPQISADIINA 656
            ....|..:  :.:|.|...:.|.:.:|
Worm   563 VESGQRHV--VTRNGELVVLDAQLEDA 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	136/512 (27%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/41 (32%)
mab-20	NP_490875.1	Sema_2A	34..477	CDD:200499	135/502 (27%)
		PSI	478..521	CDD:279745	15/49 (31%)
		IGc2	<556..596	CDD:197706	7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020