DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and AgaP_AGAP006634

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_316666.4	Gene:	AgaP_AGAP006634 / 1277221	VectorBaseID:	AGAP006634	Length:	718	Species:	Anopheles gambiae

Alignment Length:	603	Identity:	214/603 - (35%)
Similarity:	311/603 - (51%)	Gaps:	86/603 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GWMQ------VFLLLTVLVIG---NQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKD 103
            ||.:      .|:||.:|..|   .::.|      ..|.|.....|.:|...:.....|.| .::
Mosquito    14 GWWRRLVLTVAFVLLQLLRPGAGDYENTW------NFYYEQPCYHVREFQCGKFYYRTFYL-DEE 71

  Fly   104 GNSLLIGARNTVFNLSIHDL----VEQQRLVWTSPEDDTKMCLVKGKDEE-ACQNYIR-IMVVPS 162
            .::|.:||.:.||.|::.::    .|:..:|......|.:.|:.|||.|. .|:|:|| |..:.|
Mosquito    72 RDTLYVGAMDRVFKLNLKNVSMTSCERDTIVLDPTSSDIRNCVSKGKSEMFDCKNHIRVIQPMDS 136

  Fly   163 PGRLFVCGTNSFRP-----MCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADN------- 215
            ..||::||||:..|     ..|...:..|.| :.....|.|.|||||..|||::..:.
Mosquito   137 GNRLYICGTNAHNPKDLVIYSNLTHLPRSEY-VPGIGLGIAKCPYDPYDNSTAIYVEQGNPGDLP 200

  Fly   216 ELYSGTVADFSGSDPIIYREPL-------------QTEQYDSLSLNAPNFVSSFTQGDFVYFFFR 267
            .|||||.|:|:.:|.:|:|..|             :|.:|||..|:.||||.||..|:.||||||
Mosquito   201 ALYSGTNAEFTKADTVIFRTDLYNMTTGKKVFNFKRTLKYDSKWLDKPNFVGSFDIGEHVYFFFR 265

  Fly   268 ETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLV 332
            |||||:||||||:|||||||||.|.||.:.....|.::||:|:||||.|::||||||||....|
Mosquito   266 ETAVEYINCGKAVYSRVARVCKKDTGGKNILNQNWATYLKARINCSISGEFPFYFNEIQDVYQL- 329

  Fly   333 EGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDP 397
                 .......|..|.|.:|.:.|||||:|.:.:|...|.|:||||...||.||||.|:|:|:|
Mosquito   330 -----PTDKTKFYATFTTSTNGLVGSAVCSFDINEIHGAFAGKFKEQASSNSAWLPVLNSKIPEP 389

  Fly   398 RPGSCHNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTP-GGKT 461
            |||:|.||:..|||..||||::|.|||:.|....:.|:..:...:  ||::.|| :||.. ..:.
Mosquito   390 RPGTCVNDTSTLPDSVLNFIRSHPLMDKAVNHEHNNPVYYKRDLV--FTKLVVD-KIKIEILSQE 451

  Fly   462 YDVIFVGTDHGKIIKSVN-AESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSY 525
            |.|.::||:.|:|.|.|. ..:.:|..|:       :|:.    .|...|.::.|:..|.:...|
Mosquito   452 YTVFYIGTNAGRIYKIVQYLRNGESKSKL-------LDIF----EIAQNEAIQVMELSQKRKSLY 505

  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQ 590
                  :.||.::..|.|..| |.:..:|..||  :||||.|||....|:.:       |....|
Mosquito   506 ------VATDYRIKQIDLAMC-NRRYDNCFRCV--KDPYCGWDKDTSTCKPY-------EPGLLQ 554

  Fly   591 NVATGQHAACPSGKINSK 608
            :|....:..|.:..:..|
Mosquito   555 DVGNETYDICDTSVLKKK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	184/487 (38%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
AgaP_AGAP006634	XP_316666.4	Sema_2A	62..518	CDD:200499	183/483 (38%)
		Ig_Semaphorin_C	568..659	CDD:143180	1/5 (20%)
		IG_like	571..656	CDD:214653	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820