DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and AgaP_AGAP008656

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_314756.4	Gene:	AgaP_AGAP008656 / 1275507	VectorBaseID:	AGAP008656	Length:	812	Species:	Anopheles gambiae

Alignment Length:	831	Identity:	632/831 - (76%)
Similarity:	703/831 - (84%)	Gaps:	27/831 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 EDVLKFVGNESVVDHFKLVTKDGNS--LLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVK 144
            ::.|:|.||||..|.||||.:|.||  ||:||||.|:||||:||.|..||.|.|.:||.|||:||
Mosquito     2 KEYLRFQGNESTNDFFKLVLRDPNSNNLLVGARNIVYNLSIYDLAETTRLSWYSSDDDIKMCIVK 66

  Fly   145 GKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNST 209
            ||||:.||||||::.:|:.|.|..||||:|||:|.||.|:.:|||:|..|.|||:|||||.||||
Mosquito    67 GKDEDLCQNYIRVLAIPAQGSLLSCGTNAFRPLCRTYSINGNNYTVETEKPGQAMCPYDPTHNST 131

  Fly   210 SVLADNELYSGTVADFSGSDPIIYREPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFI 274
            :|..||||||||||||||.|||||||.|||||||||||||||||.||||||||||||||||||||
Mosquito   132 AVFVDNELYSGTVADFSGLDPIIYREHLQTEQYDSLSLNAPNFVGSFTQGDFVYFFFRETAVEFI 196

  Fly   275 NCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSM 339
            ||||||:||||||||||||||:|.:|||||:||||||||:|||:||||:||||.||||||:||..
Mosquito   197 NCGKAIFSRVARVCKWDKGGPNRLKNRWTSYLKSRLNCSMPGDFPFYFDEIQSTSNLVEGRYGHA 261

  Fly   340 SSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHN 404
            :||||||||:|..|:|.|||:|||:||:|:|||||.||||:|:||||||||...|||||||||||
Mosquito   262 NSKLIYGVFSTAPNAIAGSAICAFSLQEISDTFEGNFKEQSGLNSNWLPVNPLNVPDPRPGSCHN 326

  Fly   405 DSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGT 469
            |||.|||.||||.||||||||.|||||..|||.|.||:||||.||||.|||||||||||||||||
Mosquito   327 DSRTLPDLTLNFKKTHSLMDETVPAFFGSPILTRVSTMYRFTAIAVDPQIKTPGGKTYDVIFVGT 391

  Fly   470 DHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVT 534
            |||||:|:||||||||..|||||||||||.|..:||||.||||||.|||.|||||||||||||||
Mosquito   392 DHGKILKTVNAESADSNKKVTSVVIEEIDALQTNEPIRTLEIVRTTQYDTPKDGSYDDGKLIIVT 456

  Fly   535 DSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAA 599
            |:.|:||:||||.::|||||||||||||||||||||.|||||||||||.|||.|||:||||.|||
Mosquito   457 DTTVLAIKLHRCSSEKITSCSECVALQDPYCAWDKIVGKCRSHGAPRWSEENVFYQSVATGDHAA 521

  Fly   600 CPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLV 664
            |||||: :||||..|::|:|.:.|      |..|:...::.:.|.:||||:.|:|||||||||||
Mosquito   522 CPSGKM-AKDANVVERQGYRGEDD------QPADKIQFNSENYNDKGPQITPDLINAQYTVETLV 579

  Fly   665 MAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLL 729
            ||||||:||:|||||.||||||||||||||||||||||||||||||||: :|....|||.|||||
Mosquito   580 MAVLAGAIFALLVGFITGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNL-AFAVFFRIQAEPKLL 643

  Fly   730 PQVEEVTYAEPVLLPQPPPPNKM-HSPKNTLRKPPMHQMHQGPNSETLFQFQPDGY-NTQQSYRG 792
            |||||||||||||||||...||| ||||||||||..|  |.|.|||||||||||.| |.:.:|||
Mosquito   644 PQVEEVTYAEPVLLPQPSSQNKMQHSPKNTLRKPMGH--HHGVNSETLFQFQPDNYNNARDNYRG 706

  Fly   793 RDNFGTLRSHQVM---GDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSN 854
            ||||||||||||.   |||||||||||||||||| |.|:|||||||||.:|||||||:||||||:
Mosquito   707 RDNFGTLRSHQVRCQGGDNYRRGDGFSTTRSVKK-VLNSNTRNRSLGRMKRQPPRHGMVTQHRSD 770

  Fly   855 SPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRD 905
            ||.         |||||||||||||||||||||||||||||||||||||||
Mosquito   771 SPH---------HSSSGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRD 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	351/456 (77%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	29/33 (88%)
AgaP_AGAP008656	XP_314756.4	Sema_1A	11..468	CDD:200498	351/456 (77%)
AgaP_AGAP008656	XP_314756.4	PSI	467..523	CDD:279745	47/55 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	668	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H122327
Inparanoid	1	1.050	1175	1.000	Inparanoid score	I639
OMA	1	1.010	-	-		QHG28691
OrthoDB	1	1.010	-	-		D17608at50557
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		oto105962
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
TreeFam	1	0.960	-	-
	12	12.040