Protein Alignment Sema1a and SEMA4B

DIOPT Version :10

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_001310963.1
• Gene: SEMA4B / 10509
• HGNCID: 10730
• Length: 847
• Species: Homo sapiens
• Alignment Length: 867
• Identity: 249/867 - (28%)
• Similarity: 382/867 - (44%)
• Gaps: 197/867 - (22%)

  Fly    52 VFLLLTVLVIGNQSAWQENIRPKLYVELGPED--VLKF----VGNESVVDHFKLVTKDGNSLLIG 110
            :.|||.:|:......|.  :.|::.:.||.|:  .|:|    :.|.:.:    |:::||.:|.:|
Human    27 LLLLLLLLLQPPPPTWA--LSPRISLPLGSEERPFLRFEAEHISNYTAL----LLSRDGRTLYVG 85

  Fly   111 ARNTVF----NLSIHDLVEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLFVCG 170
            ||..:|    |||.....|.|.|:|.:..:..:.|..|||| :..|||||:|::..|...||.||
Human    86 AREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLSGSHLFTCG 150

  Fly   171 TNSFRPMCNTYIISDSNYTLEATKNGQAV-------CPYDPRHNSTSVLADNELYSGTVADFSGS 228
            |.:|.||| || |:..|:||...:.|..:       ||:||...||:::.|.|||:|||:.|.|:
Human   151 TAAFSPMC-TY-INMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGN 213

  Fly   229 DPIIYR----EPLQTEQYDSLS-LNAPNFVSS--------FTQG--DFVYFFFRETAVEFINCGK 278
            ||.|.|    .|.:||  .||: |..|.||:|        ..||  |.:||||.||..||.....
Human   214 DPAISRSQSLRPTKTE--SSLNWLQDPAFVASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFEN 276

  Fly   279 AIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKL 343
            .|.||:||:||.|:||....:.|||||||::|.||.|.| .|.||.:|....|..... .....|
Human   277 TIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDD-GFPFNVLQDVFTLSPSPQ-DWRDTL 339

  Fly   344 IYGVFNTP--SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---- 402
            .||||.:.  ..:..|||||.|.::|:...|.|.:||.......|..|.: .||.||||:|
Human   340 FYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFSGLYKEVNRETQQWYTVTH-PVPTPRPGACITNS 403

  Fly   403 -----HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG-GKT 461
                 .|.|..|||..|||:|.|.|||..|.   |:.:|::...  |:.::||.   :.|| ..|
Human   404 ARERKINSSLQLPDRVLNFLKDHFLMDGQVR---SRMLLLQPQA--RYQRVAVH---RVPGLHHT 460

  Fly   462 YDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYD 526
            |||:|:||..|::.|:|:.     ..:|.  :|||:.:.:..:|::|| ::.|.:..:|.... .
Human   461 YDVLFLGTGDGRLHKAVSV-----GPRVH--IIEELQIFSSGQPVQNL-LLDTHRVSRPTRNP-G 516

  Fly   527 DGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPR-----WLE-- 584
            .|.|...:.|.||.:.:..|  ....||.:|:..:||||||...:.|..|...|:     |::
Human   517 RGLLYAASHSGVVQVPMANC--SLYRSCGDCLLARDPYCAWSGSSCKHVSLYQPQLATRPWIQDI 579

  Fly   585 ENYFYQNVATGQHAACPS----------------GKINSKD----ANAGEQKGFRN--------- 620
            |....:::.:......||                ..:|:..    :|...:...||
Human   580 EGASAKDLCSASSVVSPSFVPTGEKPCEQVQFQPNTVNTLACPLLSNLATRLWLRNGAPVNASAS 644

  Fly   621 -------DMDLLDSRRQSKDQ-----------------EIIDN--IDKNFEGPQ----ISADIIN 655
                   |:.|:.:::..:.|                 |::::  .|:..||..    ||...::
Human   645 CHVLPTGDLLLVGTQQLGEFQCWSLEEGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVS 709

  Fly   656 A------------QYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFE 708
            |            .|..|.|||..|  .:.::|:......:..|...|             .:.:
Human   710 APAGGKASWGADRSYWKEFLVMCTL--FVLAVLLPVLFLLYRHRNSMK-------------VFLK 759

  Fly   709 QRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQG--- 770
            |.:..:..|.:|                   ||:||....|.....|.:|   |..|:.:|.
Human   760 QGECASVHPKTC-------------------PVVLPPETRPLNGLGPPST---PLDHRGYQSLSD 802

  Fly   771 --PNSETLFQFQPDGYNTQQSY 790
              |.|....:.:....:.|.|:
Human   803 SPPGSRVFTESEKRPLSIQDSF 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	180/493 (37%)
		PSI	545..601	CDD:396154	15/62 (24%)
SEMA4B	NP_001310963.1	Sema	61..534	CDD:472829	182/500 (36%)
		PSI	535..581	CDD:396154	14/47 (30%)
		Ig_Sema4B_like	604..687	CDD:409456	8/82 (10%)
		Ig strand A	604..610	CDD:409456	0/5 (0%)
		Ig strand B	614..622	CDD:409456	1/7 (14%)
		Ig strand C	628..634	CDD:409456	0/5 (0%)
		Ig strand C'	636..639	CDD:409456	0/2 (0%)
		Ig strand D	645..649	CDD:409456	0/3 (0%)
		Ig strand E	651..657	CDD:409456	2/5 (40%)
		Ig strand F	662..671	CDD:409456	1/8 (13%)
		Ig strand G	674..687	CDD:409456	1/12 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..815		8/40 (20%)