DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and SEMA4D

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001358123.1	Gene:	SEMA4D / 10507	HGNCID:	10732	Length:	862	Species:	Homo sapiens

Alignment Length:	859	Identity:	237/859 - (27%)
Similarity:	368/859 - (42%)	Gaps:	158/859 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            |:::|.::|.||||..||.::..::.|:|..| |...||....|..|||.::. |.||||::...
Human    54 LLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPL 118

  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226
            |...|:|||||:|:|.|:...::...: |...::|:..||:||.|:.|||:.|.||||||..:|.
Human   119 SATSLYVCGTNAFQPACDHLNLTSFKF-LGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFL 182

  Fly   227 GSDPIIYR----EPLQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFFRETAVEFINCG 277
            ||:|||.|    .||:|| |....||.|:||          |...:.|.|||||.|.:||:....
Human   183 GSEPIISRNSSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVF 246

  Fly   278 KAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK 342
            :.:..|:|||||.|:||....:.:||||||:||.||.| |....||.::....|   :...:...
Human   247 RVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVL---RSPGLKVP 307

  Fly   343 LIYGVFNTPSNSIPGSAVCAFALQDIADTF-EGQFKEQTGI---NSNWLPVNNAKVPDPRPGSC- 402
            :.|.:|....|::..|||||:.|....:.| .|::.:.|.:   ::.|:.. |..||.||||:|
Human   308 VFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRY-NGPVPKPRPGACI 371

  Fly   403 HNDSRA--------LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGG 459
            .:::||        |||.||.|:|.|.|||::|....::|.|::....|  |||.|| :.:...|
Human   372 DSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVD-RTQALDG 433

  Fly   460 KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGS 524
            ..|||:||.||.|.:.|:::.|.|..       :|||..:....||::.|.:            |
Human   434 TVYDVMFVSTDRGALHKAISLEHAVH-------IIEETQLFQDFEPVQTLLL------------S 479

  Fly   525 YDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC----RSHGAPRWLEE 585
            ...|...:...|....:|.......|..:|.:||..:||||||......|    ::....|.|.:
Human   480 SKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQ 544

  Fly   586 NYFYQNVATGQHAACPSGKINS------KDANAGEQK------------GFRNDMDLLDSRR--- 629
            .      .:|..:.||.....|      |.....|.|            .|:|.:...:|.:
Human   545 E------MSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGL 603

  Fly   630 QSKDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDED 694
            ..:...:|.|:.   ||.......::.:......|..|:|..:..:.|
Human   604 MGRKNLLIFNLS---EGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKV----------------- 648

  Fly   695 DNLPYP---------DTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750
              :|.|         .||......:..|.|...|     .|. .|.|:..:.....|.|:|.|..
Human   649 --VPKPVVAPTLSVVQTEGSRIATKVLVASTQGS-----SPP-TPAVQATSSGAITLPPKPAPTG 705

  Fly   751 KMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDG-------------------YNTQQSYRGRDNF 796
            ....||..:...|  |:|   :.:|::....|.                   ||..:.|..|...
Human   706 TSCEPKIVINTVP--QLH---SEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCL 765

  Fly   797 GTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQ 861
             ..||..::|....:.|.....:|:|:    |.....|..:...:.|:..:.|.:.:   :|...
Human   766 -KFRSALLIGKKKPKSDFCDREQSLKE----TLVEPGSFSQQNGEHPKPALDTGYET---EQDTI 822

  Fly   862 QSQQPHSSSGSSPV 875
            .|:.|.....|..:
Human   823 TSKVPTDREDSQRI 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	167/475 (35%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/37 (30%)
SEMA4D	NP_001358123.1	Sema_4D	31..501	CDD:200520	167/475 (35%)
		PSI	503..554	CDD:214655	14/56 (25%)
		Ig_Sema4D_like	559..645	CDD:143281	14/88 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..837		7/46 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910