DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and SEMA4F

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_004254.2	Gene:	SEMA4F / 10505	HGNCID:	10734	Length:	770	Species:	Homo sapiens

Alignment Length:	793	Identity:	214/793 - (26%)
Similarity:	337/793 - (42%)	Gaps:	159/793 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVELGPED------VLKFVGNESVVDHFKLVTKDGNSLLIGAR 112
            |||..::.|..|.......|:..:.:...|      .:....|.||:    ||....::|.:|||
Human    22 LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVL----LVDPASHTLYVGAR 82

  Fly   113 NTVFNLSIHDLVEQ-QRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRP 176
            :|:|.||:....|: :|:.|..||...:.|..|||.|:.|.|:::|:.:.:...|..|||.:|.|
Human    83 DTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDP 147

  Fly   177 MCNTYIISDSNY-TLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREPLQTE 240
            .|.  :|..|.: .:|..::|:..||::|...|.:|:|...||:.||.::.|::|||.|...:.|
Human   148 KCG--VIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAE 210

  Fly   241 QY---DSLS--LNAPNFVSSFTQG----------DFVYFFFRETAVEFINCGKAIYSRVARVCKW 290
            .:   |:|.  ||||.||::....          |.:||||.||:..|.:..:....||||||..
Human   211 DWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAG 275

  Fly   291 DKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG------QYGSMSSKLIYGVFN 349
            |.||....:.|||:|||:.|.|  ||.      |...||::::.      :.|: .:.:.||:|:
Human   276 DLGGRKTLQQRWTTFLKADLLC--PGP------EHGRASSVLQDVAVLRPELGA-GTPIFYGIFS 331

  Fly   350 TPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---------HND 405
            :.......||||||..|||.....|.|:|.....:..|||.:..||.||||.|         ...
Human   332 SQWEGATISAVCAFRPQDIRTVLNGPFRELKHDCNRGLPVVDNDVPQPRPGECITNNMKLRHFGS 396

  Fly   406 SRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDA-QIKTPGGKTYDVIFVGT 469
            |.:|||..|.||:.|.|||..|......|:||.|.|.|    :.|.| ::.:..||.|||:::||
Human   397 SLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAY----LRVVAHRVTSLSGKEYDVLYLGT 457

  Fly   470 DHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVT 534
            :.|.:.::|...:..|       |:|::.:..:.:|:.|:::..:.              |::.:
Human   458 EDGHLHRAVRIGAQLS-------VLEDLALFPEPQPVENMKLYHSW--------------LLVGS 501

  Fly   535 DSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSH-GAPRWLEEN------------ 586
            .::|..:....|  .::.|||||:..|||.|||.....:|.:| |..|.|.::
Human   502 RTEVTQVNTTNC--GRLQSCSECILAQDPVCAWSFRLDECVAHAGEHRGLVQDIESADVSSLCPK 564

  Fly   587 -------YFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNF 644
                   .|...|||..|...|....::..:....|.   :.:..|..||...:..:.......:
Human   565 EPGERPVVFEVPVATAAHVVLPCSPSSAWASCVWHQP---SGVTALTPRRDGLEVVVTPGAMGAY 626

  Fly   645 --EGPQISADIINAQYTV-----------ETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDN 696
              |..:..|..:.|.|::           ...|.|.|||....:|....|....|||..:.....
Human   627 ACECQEGGAAHVVAAYSLVWGSQRDAPSRAHTVGAGLAGFFLGILAASLTLILIGRRQQRRRQRE 691

  Fly   697 L-------------PYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVT------------ 736
            |             |...|.|.                 |..|...|:.|.:.
Human   692 LLARDKVGLDLGAPPSGTTSYS-----------------QDPPSPSPEDERLPLALAKRGSGFGG 739

  Fly   737 YAEPVLLPQPPPP 749
            ::.|.||...|.|
Human   740 FSPPFLLDPCPSP 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	152/487 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/34 (41%)
SEMA4F	NP_004254.2	Sema_4F	52..511	CDD:200522	153/498 (31%)
		PSI	512..563	CDD:279745	17/52 (33%)
		Ig_Sema4B_like	570..649	CDD:143280	14/81 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..725		6/45 (13%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q9Z123	768..770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910