DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and SEMA6B

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_011525941.1	Gene:	SEMA6B / 10501	HGNCID:	10739	Length:	894	Species:	Homo sapiens

Alignment Length:	1080	Identity:	299/1080 - (27%)
Similarity:	441/1080 - (40%)	Gaps:	299/1080 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVELGPEDVLK----FVGN--------ESVVD-HFKLVTKDGN 105
            |||.:|:.|....:.|...|   :.:.|.|.|.    |||:        |...| :.:.|.:...
Human    14 LLLLLLLGGAHGLFPEEPPP---LSVAPRDYLNHYPVFVGSGPGRLTPAEGADDLNIQRVLRVNR 75

  Fly   106 SLLIGARNTVFNLSIH-----DLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGR 165
            :|.||.|:.::.:.:.     :|..|::|.|.|...|..:|.:|||.|..|:|:::::::.....
Human    76 TLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGKQEGECRNFVKVLLLRDEST 140

  Fly   166 LFVCGTNSFRPMCNTYIISDSNYTLEATK------NGQAVCPYDPRHNSTSVLADNELYSGTVAD 224
            |||||:|:|.|:|       :||:::..:      :|.|.|||||:|.:.::.:|..|::.||.|
Human   141 LFVCGSNAFNPVC-------ANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTATVTD 198

  Fly   225 FSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRV 284
            |...|.:|||.     .|:|.::||.....|.||.:...|..|||||||.|:||....|.:.|||
Human   199 FLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRV 263

  Fly   285 ARVCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK-LIYGV 347
            |||||.|.|| |.....:||||||:|||||:|||..||||.:|:.:.:|     |:..: ::..|
Human   264 ARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVV-----SLGGRPVVLAV 323

  Fly   348 FNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC------HNDS 406
            |:||||||||||||||.|..:|..|||:|:||....|.|.||...:||.||||.|      :|.|
Human   324 FSTPSNSIPGSAVCAFDLTQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNAS 388

  Fly   407 RALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDH 471
            .||||..|||:|||.||||.||:....|.::||...::.|::|||......|.:|  |:|:|::.
Human   389 SALPDDILNFVKTHPLMDEAVPSLGHAPWILRTLMRHQLTRVAVDVGAGPWGNQT--VVFLGSEA 451

  Fly   472 GKIIK-SVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTD 535
            |.::| .|...::.|.....||.:||            .|..|..:..:|..|......|.:..|
Human   452 GTVLKFLVRPNASTSGTSGLSVFLEE------------FETYRPDRCGRPGGGETGQRLLSLELD 504

  Fly   536 SQ-----------VVAIQLHRCHN----DKITSCS-ECVALQDPYCAWDKIAGKCRSHGAPRWLE 584
            :.           ||.:.:.||..    .|...|| .|:..|||||.|.. .|.|
Human   505 AASGGLLAAFPRCVVRVPVARCQQYSGCMKSLVCSRNCIGSQDPYCGWAP-DGSC---------- 558

  Fly   585 ENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQI 649
              .|   ::.|..||.      .:|.:.....|..:...||   |.|..::
Human   559 --IF---LSPGTRAAF------EQDVSGASTSGLGDCTGLL---RASLSED-------------- 595

  Fly   650 SADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR------CHKDEDDNLPYPDTEYEYFE 708
            .|.:::....|.:.|.|.:.|::.|   ||..|:|.|.|      ..||::..|.:...|.....
Human   596 RAGLVSVNLLVTSSVAAFVVGAVVS---GFSVGWFVGLRERRELARRKDKEAILAHGAGEAVLSV 657

  Fly   709 QRQNVNSFPSSCRIQQEP----------------KLLPQVEEVTYAEPVLL---PQP------PP 748
            .|...       |..|.|                .||..:.:..:|:..||   |..      |.
Human   658 SRLGE-------RRAQGPGGRGGGGGGGAGVPPEALLAPLMQNGWAKATLLQGGPHDLDSGLLPT 715

  Fly   749 PNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGD 813
            |.:...|:..|..|..|....||                   |..|:     .|.::
Human   716 PEQTPLPQKRLPTPHPHPHALGP-------------------RAWDH-----GHPLL-------- 748

  Fly   814 GFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSN 878
                     .|..:::....:..||..|||..|..|      |..:...::...:|.|..|:
Human   749 ---------PASASSSLLLLAPARAPEQPPAPGEPT------PDGRLYAARPGRASHGDFPL--- 795

  Fly   879 SSSSPAPPSSSPSPQESPKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQSHPHPLPPP----- 938
                  .|.:||..:.             :.:..:.||..|.:....|.|.|     |||
Human   796 ------TPHASPDRRR-------------VVSAPTGPLDPASAADGLPRPWS-----PPPTGSLR 836

  Fly   939 ---GPTTPPAQPRARSPMIGRTYAKSMPVTPVQPQSPLAETPSYELYERHSDAATFHFGDEDDDD 1000
               ||..|||      ..:.||:                               ||:.|:....|
Human   837 RPLGPHAPPA------ATLRRTH-------------------------------TFNSGEARPGD 864

  Fly  1001 DDEHDHEDTSSLAMITPPPPYDTPHLI-------ASPPLP 1033
            .....|          ..|..|..||:       .:||:|
Human   865 RHRGCH----------ARPGTDLAHLLPYGGADRTAPPVP 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	182/491 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/38 (37%)
SEMA6B	XP_011525941.1	Sema_6B	57..524	CDD:200528	182/492 (37%)
SEMA6B	XP_011525941.1	PSI	525..>560	CDD:279745	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.860