DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema5b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_031748739.1	Gene:	sema5b / 100493363	XenbaseID:	XB-GENE-959729	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	948	Identity:	271/948 - (28%)
Similarity:	404/948 - (42%)	Gaps:	259/948 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVC 169
            |.|::||||.:|.||:|::...|...|:|.||..:.|..|||.|:.||||:|:::| |..|:|.|
Frog    86 NQLIVGARNYLFRLSLHNVSLIQAAEWSSDEDTQRSCQSKGKTEDECQNYVRVLIV-SGKRVFTC 149

  Fly   170 GTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLAD-NELYSGTVADFSGSDPIIY 233
            |||:|.|:|.:..:.:.:..:|.. ||.|.||||||||||:|:.. .|||:.||.||||.||:||
Frog   150 GTNAFSPVCTSRQVGNLSKVIEKI-NGVARCPYDPRHNSTAVMTTRGELYAATVIDFSGRDPVIY 213

  Fly   234 RE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKG 293
            |.     ||:|.||:|..||.||||:::..|.|.||||||.|||. :|||.:|||||||||.|.|
Frog   214 RSLGSVPPLRTAQYNSKWLNEPNFVAAYDIGIFTYFFFRENAVEH-DCGKTVYSRVARVCKNDYG 277

  Fly   294 GPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGS 358
            |.....:.||:|:|:|||||.||:.|||:||:||...|.|       ..||||||.|..|||..|
Frog   278 GRFLLEDTWTTFMKARLNCSRPGEIPFYYNELQSTFLLPE-------QDLIYGVFTTNVNSIAAS 335

  Fly   359 AVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDS-------RALPDPTLNF 416
            |||||.|..|...|.|.|:.|....|.|||..| .:|:.:.|..::||       |:|.|....|
Frog   336 AVCAFNLSAITQAFNGPFRYQENPRSAWLPTIN-PIPNFQCGILNDDSPNENLTERSLQDAQRLF 399

  Fly   417 IKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKT-YDVIFVGTDHGKIIKSVNA 480
                 ||::.|.....:|::.:.|.  ||:::.||.   ..|..| |.|:::||:||.|:|:::.
Frog   400 -----LMNDVVQPVSVEPLVTQDSV--RFSKLVVDI---VQGKDTLYHVMYIGTEHGTILKALST 454

  Fly   481 ESADSADKVTSVVIEEIDVLT--KSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQL 543
            .:.    .:.|..:||:.:|.  :.||||:|:|:            :.:..|.:..::.|:.:.|
Frog   455 ANR----SLRSCYLEEMHILPIGQQEPIRSLQIL------------HSNRSLFVGLNNGVLKVPL 503

  Fly   544 HRC-----HNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPR---------------------- 581
            .||     ..|::       ..:||||.||....:|.. ..|.
Frog   504 ERCSIYRTEGDRL-------GARDPYCGWDSKKKRCTPXAYPHYITGPRNTLSCPVSGLTVHGGR 561

  Fly   582 ---WLEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKN 643
               |:..    ::..||....||..::..            |.:.....|.....:..|.|..:|
Frog   562 GAWWVRA----KHSPTGLFGLCPFPRVCD------------NPLPRCGGRDCDGTRIEIANCSRN 610

  Fly   644 -------------------FE---------GPQISADIINAQYTVETLVMAVLAGSIFSLLVGFF 680
                               |:         .|:. ..:...|...|.:.|             ..
Frog   611 GGWTPWSSWAQCSTSCGIGFQVRQRTCSNPAPRCXGRVCVGQSREERVKM-------------ML 662

  Fly   681 TGYFCGRRCHKDEDDNLPYPDTEY-----------------EYFEQR--QNVNSFPSSCRIQQEP 726
            .|.||        ::|.|.|...:                 .:..||  :|.|:.| .|.::..|
Frog   663 DGLFC--------NENSPCPVPIFWTSWGSWTKCSSDCGGGTHSRQRSCENGNTCP-GCAMEFRP 718

  Fly   727 ---KLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKP--PMHQMHQGPNSETLFQFQ-----P 781
               :..|:|.                      :||...|  |::....|...|..|::.     .
Frog   719 CNSEPCPEVR----------------------RNTPWTPWTPVNITQGGARQEQRFRYTCRAQLA 761

  Fly   782 DGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFS---TTRSVKKAVNNTNTRNRSLG------- 836
            |.:|.|        ||..::......|    ||.:   |...|...:.|:.|..|::.
Frog   762 DPHNLQ--------FGRKKTETRFCPN----DGSAACETDTLVDDLMRNSKTPGRTVSGGWSPWS 814

  Fly   837 -------------RARRQ-----PPRHGIVTQHRSNSPQQQQQQSQQPHSSSGS----SPVMSNS 879
                         |.|::     .||:|.:.  .:.|..:.|..:.||....||    ||....|
Frog   815 GWSSCSRECELGFRTRKRTCSNPEPRNGGLP--CAGSAMEYQDCNPQPCPVKGSWSCWSPWTQCS 877

  Fly   880 SS------SPAPPSSSPSPQESPKNCSYIYRDXLICNT 911
            ::      ......::|.|......|..::.:..:|||
Frog   878 ATCGGGHYQRTRTCTNPPPSNGGDICIGLHTEEALCNT 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	190/456 (42%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	10/38 (26%)
sema5b	XP_031748739.1	Sema_5B	68..504	CDD:200525	189/454 (42%)
		PSI	505..>533	CDD:214655	9/34 (26%)
		TSP1	613..674	CDD:214559	10/81 (12%)
		TSP1	679..725	CDD:214559	7/46 (15%)
		TSP1	810..862	CDD:214559	9/53 (17%)
		TSP1	867..919	CDD:214559	9/49 (18%)
		TSP1	922..963	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910