DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema3d

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_002935293.5	Gene:	sema3d / 100492784	XenbaseID:	XB-GENE-490694	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	683	Identity:	193/683 - (28%)
Similarity:	325/683 - (47%)	Gaps:	97/683 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 MKHKLSKFYGYGWMQ------VFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGN----- 90
            ||.|..|:.| .|::      :..::.::.:....:.::|| |:|  :|..:|:|  :.|
Frog     1 MKEKHQKYLG-RWLKPQHSSTMLSMVLLMFLPATDSLKQNI-PRL--KLSYKDLL--LSNSCVPF 59

  Fly    91 -----ESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEE 149
                 |.:.....|:.::...||:||::.::.|.:.||.:..|.: |.:.::..:.|...|||..
Frog    60 LHPLTEGLEFQTLLLDEERGKLLLGAKDHIYLLDLVDLNKNLRKIHWPAAKEKIEFCKRAGKDNN 124

  Fly   150 -ACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSN----YTLEATKN---GQAVCPYDPRH 206
             .|.|:|:::...:....:.|||.:|.|:|....:....    :.|: |:|   |:..||:||:.
Frog   125 LECANFIKVLHHYNKTHAYTCGTGAFHPLCGYVELGTPKEEVVFQLD-TQNLESGRLKCPFDPQP 188

  Fly   207 NSTSVLADNELYSGTVADFSGSDPIIYREP--------LQTEQYDSLSLNAPNFVSSFT------ 257
            ...|::.|..|::||.:||.|.:....|..        ::|:..|...||...|..::.
Frog   189 PFASIMTDEYLFAGTASDFLGKETTFTRSMGPPPDHHFIKTDTDDHYWLNGAKFFGAYAIPDTYN 253

  Fly   258 -QGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIP----GD 317
             ..|.:||||||::.|.....|:::|||.||||.|.||.....|:||:|||:||.||||    ||
Frog   254 PDDDKIYFFFRESSPEGSFSEKSVFSRVGRVCKNDIGGQRSLINKWTTFLKARLVCSIPAQDGGD 318

  Fly   318 YPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGI 382
              .||:|:|....|   ......:.::||:|.|.|:....||||.:::.||...|.|.:..:...
Frog   319 --TYFDELQDIFLL---PTKDERNPVVYGIFTTTSSIFKASAVCVYSMADIRAVFNGPYAHKESP 378

  Fly   383 NSNWLPVNNAKVPDPRPGSCHN--------DSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRT 439
            :..|:.. :.::|.||||:|.:        .::..||..:||:|.|.||.:.|.....:|:..|.
Frog   379 DHRWVQY-DGRIPYPRPGTCPSKTYDPTIRSTKDFPDDVINFVKNHPLMYKAVYPLHGKPVFTRL 442

  Fly   440 STIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSAD--KVTSVVIEEIDVLTK 502
            :..|:.||||||..:...|  .|||:|:|||.|.::|.:..    :.|  .:..|::||:.:..:
Frog   443 NVDYKLTQIAVDHVVAEDG--QYDVMFLGTDIGTVLKVITV----TKDIWNMEEVLLEEMQIFKQ 501

  Fly   503 SEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAW 567
            ...|.|:|:            |....:|.|.::..:|.:.|||| :....:|::|...:||||||
Frog   502 PAAITNIEL------------SLKQQQLYITSEVGLVQLSLHRC-DTYGKACTDCCLARDPYCAW 553

  Fly   568 DKIAGKCRSHGAPRWLEENYFYQNVATGQH-AACPSGKINSKDANAGEQK--GFRNDMDLLDSRR 629
            |   |...|...|. .:.....|:|..|.. ..|...:.|:....|.|:.  |..|:...|:...
Frog   554 D---GNSCSRYVPT-SKRRARRQDVKNGDPLTQCWDVEDNTNQEPAEEKVIFGIENNSTFLECMP 614

  Fly   630 QSKDQEIIDNIDKNFEGPQ--ISAD--IINAQY 658
            :|:...|...|....|..|  |::|  ||...|
Frog   615 KSQQASIRWFIQHTGEEHQEEITSDERIIKTDY 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	145/492 (29%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
sema3d	XP_002935293.5	Sema_3D	60..533	CDD:200513	145/497 (29%)
		PSI	532..569	CDD:214655	14/41 (34%)
		Ig_Sema3	594..685	CDD:409455	15/54 (28%)
		Ig strand B	608..612	CDD:409455	1/3 (33%)
		Ig strand C	620..624	CDD:409455	1/3 (33%)
		Ig strand E	647..651	CDD:409455	1/1 (100%)
		Ig strand F	661..666	CDD:409455
		Ig strand G	678..681	CDD:409455
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110