DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema4b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_031755080.1	Gene:	sema4b / 100489037	XenbaseID:	XB-GENE-922109	Length:	850	Species:	Xenopus tropicalis

Alignment Length:	897	Identity:	264/897 - (29%)
Similarity:	395/897 - (44%)	Gaps:	221/897 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 WQENIRPKLYVELGPEDVLKFVGNESVVDHFK--LVTKDGNSLLIGARNTVFNLSIHDLVE---Q 126
            |.|..|.      .||...|....:.|. :|.  |:.|||::|.:||:..:|:|:..|...   .
Frog    41 WDETFRG------SPERSFKTFEADGVT-YFTTLLLGKDGSALYVGAQEALFSLNSTDFTSADYH 98

  Fly   127 QRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYI-ISDSNYT 189
            .::.|.:.|:..|.|..|||| :..|||||:|::..:...|:.|||.:|.|.| ||| |||  ::
Frog    99 SKIAWQADEEKKKECAFKGKDPQRDCQNYIKILLQLNSTHLYTCGTFAFSPTC-TYIKISD--FS 160

  Fly   190 LEAT-------KNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIY-----REPLQTEQY 242
            ||..       ::|:..||:||.:|||:::.|.|:|:|||::|.|::||||     |..|:||
Frog   161 LEKNALGHPILEDGKVRCPFDPEYNSTAIMVDGEMYAGTVSNFQGNEPIIYKSHDSRITLKTE-- 223

  Fly   243 DSLS-LNAPNFV-SSFTQ-----------GDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGG 294
            :||. |..|.|| |::.|           .|.:|:||.||..||......|.||:|||||.|.||
Frog   224 NSLYWLQDPAFVGSAYIQESLPKGNPVGDDDKIYYFFSETGKEFDFFENTIVSRIARVCKGDLGG 288

  Fly   295 PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSN--SIPG 357
            ....:.|||||||::|.||.||| .|.||.::....|..|: ....|.:.||||.:..|  ....
Frog   289 ERVLQRRWTSFLKAQLICSCPGD-GFPFNVLKDMFVLTPGE-EHWKSTIFYGVFTSQWNKGGAGS 351

  Fly   358 SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---------HNDSRALPDPT 413
            ||||||::.::.:.|.|.|||.......|....|: ||:||||:|         .|.|..:||..
Frog   352 SAVCAFSMDEVQNAFNGLFKEVNRETQQWYTYTNS-VPEPRPGACITNSARDKKINSSLQMPDRV 415

  Fly   414 LNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG-GKTYDVIFVGTDHGKIIKS 477
            |||:|.|.|||.   |..|||:|:::.  .|:.||:|.   :..| .|||||:|:|||.|::.|:
Frog   416 LNFVKDHFLMDS---AIRSQPLLLQSQ--IRYQQISVQ---RVRGLKKTYDVLFLGTDDGRLHKA 472

  Fly   478 VNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQ 542
            |      |.:|:.. :||||.:....:|::.|.:              |..|.:|...|:...:|
Frog   473 V------SVNKMVH-IIEEIKLFQDMQPVQELLL--------------DPSKGLIYASSRSAVVQ 516

  Fly   543 LHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAP---------RWLEENYFYQNVATGQHA 598
            :...:.....||.||:..:||||||:|..  |  |..|         .|:::   .::..|..|.
Frog   517 VPVSNCSMYRSCGECILSRDPYCAWNKKG--C--HSVPHHTHDTKNQHWVQD---IEDANTDAHC 574

  Fly   599 ACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEI--------------IDNIDKN---FEG 646
                     |.:|:.|..|.....|      :|:.|||              :.|:...   ..|
Frog   575 ---------KPSNSTEAIGRAGKPD------ESECQEISMESNPANTLPCKLLSNLASRVWLHNG 624

  Fly   647 PQI--------SADII--NAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRC---HKDEDDNLP 698
            .:|        |.|:|  ::...|.|.....:......|:|.:..|...|.:.   .:.|.:.:.
Frog   625 KEIDSSYFVLPSGDLILVSSPDRVGTYECWSVEEGFRKLMVRYCVGTQEGIKATTTQRTETEKVF 689

  Fly   699 YPDTEYEYFEQRQNVNSFPSSC--------------------------------RIQQEPK-LLP 730
            ...:..|......:|:||||:.                                |.::|.| :|.
Frog   690 SKISVIEKIVNASSVSSFPSNTAKLTGKSYWMEFVIMSTLFGIMVVILGLLLLYRNRKEMKSILK 754

  Fly   731 QVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQP-DGYNTQQSYRGRD 794
            .||                   ||.     |||......|..:|:|    | :|.|....  ..|
Frog   755 PVE-------------------HSD-----KPPKKLRKNGMPAESL----PLNGTNVPSP--AAD 789

  Fly   795 NFGTLRSHQVMGDNYRRG----DGFSTTRSVKKAVNNTNTRNRSLGRARRQP 842
            :.|    :|.:.|||...    |....|.|.|:.::.|......:..|.::|
Frog   790 HKG----YQTLNDNYIISTPIHDPVIATESEKRPLSITRDTYVEVSPACQRP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	183/498 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
sema4b	XP_031755080.1	Sema	55..520	CDD:417757	183/502 (36%)
		PSI	521..564	CDD:214655	15/46 (33%)
		Ig	594..669	CDD:416386	13/74 (18%)
		Ig strand B	602..610	CDD:409353	0/7 (0%)
		Ig strand C	616..622	CDD:409353	0/5 (0%)
		Ig strand C'	624..627	CDD:409353	1/2 (50%)
		Ig strand D	631..635	CDD:409353	0/3 (0%)
		Ig strand E	637..643	CDD:409353	2/5 (40%)
		Ig strand F	649..658	CDD:409353	1/8 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100