DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema6c

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_002937315.2	Gene:	sema6c / 100486277	XenbaseID:	XB-GENE-989787	Length:	1043	Species:	Xenopus tropicalis

Alignment Length:	1092	Identity:	302/1092 - (27%)
Similarity:	481/1092 - (44%)	Gaps:	210/1092 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVE------------LGPEDVLKFVGNESVVDHFKLVTKDGNS 106
            |||....:.:...:.:::.|...:|            |..:|....:|.:     |:.:.|...:
Frog    10 LLLVCTYLSSALVFPKDLTPIRIIETLTTSSYPWFRGLASDDDTAHLGLD-----FQKMLKLNQT 69

  Fly   107 LLIGARNTVFNLSI----HDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLF 167
            |.:.||:.|:.:.:    ..::..:.:.|.:  .|.:.|.::||..:.|.|||:::|..:...|.
Frog    70 LFVAARDHVYAIDLRRAKEAIIPDKYVTWKT--QDMENCAMRGKLRDECYNYIKVLVPKNDQTLV 132

  Fly   168 VCGTNSFRPMCNTYIISDSNYTLEATK---NGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSD 229
            .||||||.|||.:|.|.    |||...   ||||.||:|.:..:.::.||..|||.|:|||..||
Frog   133 ACGTNSFNPMCRSYKIK----TLEQEGEEFNGQARCPFDAKQANVALFADGNLYSATMADFQASD 193

  Fly   230 PIIYRE------PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVC 288
            .:|||.      .|:|.:|||..|..|:|:.:...|::|||||||.::|:...||..:|||.|||
Frog   194 AVIYRSLGEKSPVLRTVKYDSKWLREPHFIHAVEYGNYVYFFFREISMEYTTIGKVTFSRVGRVC 258

  Fly   289 KWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK-LIYGVFNTP 351
            |.|.|| |......||||||:|||||:|||..|||:.:||.|:::     ::::: .:.|||.|.
Frog   259 KNDMGGSPRVLEKYWTSFLKARLNCSVPGDSFFYFDVLQSVSDIL-----TINNRPAVIGVFGTQ 318

  Fly   352 SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRA 408
            :|||.||.|||:.:.||...|.|:||||....|.|.|:...|||.||||.|        :..|..
Frog   319 ANSITGSGVCAYYMDDIEKVFNGKFKEQKTTESAWTPIPEDKVPTPRPGCCAGYGKAATYKTSNE 383

  Fly   409 LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGK 473
            .||.||:|||::.|:||.|.:....|...:|::.::.|.:|.|......|  .|.|:|:|::.||
Frog   384 FPDETLSFIKSYPLLDEAVLSITETPWFTKTTSRFKLTHLAADTSAGPYG--NYTVLFLGSEDGK 446

  Fly   474 IIKSVNAESADSADKVTSVVIEEIDVL------TKSEPIRNLEIVRTMQYDQPKDGSYDDGKLII 532
            ::|.::..:.:|.  |.::::|:|:|.      .|.|..|    :..:|.|:      ::..|.:
Frog   447 VLKVLSGTTENST--VETLLLEDINVYNPAKCNVKKEDRR----ILGLQLDR------ENHALFV 499

  Fly   533 VTDSQVVAIQLHRCHNDKITSC-SECVALQDPYCAWDKIAGKCRSH------GAPRWLEENYFY- 589
            ...|.::.:.|.||  :...:| ..|:|.:||||.|.| :|.|.|:      ...:.:|::..:
Frog   500 AFSSCIIRVPLSRC--ELYGTCRRSCLASRDPYCVWLK-SGACASYRNDIRGSFEQDIEQSKNWG 561

  Fly   590 --QNVAT--------GQHA---ACPSGKIN-SKDANAG-------EQKGFRND-MDLLDSRRQSK 632
              |:|.|        |..|   |.|||.|. :..|:.|       ...|..:| ...|.:....|
Frog   562 NCQDVVTSSGSVGNEGDSAYGKAPPSGDIAIASVASLGHVTRLGYSPPGVTSDGYYQLSAWHTLK 626

  Fly   633 DQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHK------ 691
            .|.:...:     |...|:..::..:.:..:.:|.:.|:|||   |.|...:|.....|
Frog   627 TQGVRQEV-----GSMESSKSVHFTFLIGCVFVAFVVGAIFS---GLFVSCYCNHMFQKNKHVGR 683

  Fly   692 DEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQ-QEPKLL--------PQVEEVTYAE----PVLL 743
            |.:.:|..|.:.....:....:.|.....|:: ..|||.        .|..|.|..|    |.|.
Frog   684 DPESSLQRPLSLRSLAKMNGLLESQSKEGRMEPTSPKLYTTLLHGEKEQTTETTKGESKDHPELS 748

  Fly   744 PQPPPPNKMHSPKNTLR--------------------KPPMHQMHQGPNSETLFQF--------Q 780
            ..|.|.:....|...|:                    |.|:  .|...::..:|||        .
Frog   749 GLPTPESTPELPMKNLKAFKNQWERNQNCNNAKEIQGKSPV--FHFPVSNSQVFQFPSTLVLPTN 811

  Fly   781 PDGYNTQQSYRGRD------NFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRAR 839
            ..||:...|..|.|      ....:|..|..   ..:|...:|...:.|.:..::...|.:....
Frog   812 MHGYDQPLSGYGDDKKIPNSERALIRHSQCY---LPKGVEMTTLDELLKHLPESSGSPRKMSGMM 873

  Fly   840 RQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSP-----SPQESPKNC 899
            ...|:  .|:.|   ||.....:.|.....:.|:|..   |||..|..|.|     .|..:|::|
Frog   874 AISPQ--AVSPH---SPMSFINKVQPKIPDTESAPYY---SSSTLPRDSLPRRLDIPPDVTPQSC 930

  Fly   900 ----SYIYRDXLICNTKSM------PLIQAQSTHAQPHPQSHPHPLPPP-----GPTTPPAQPRA 949
                |...|..|....|.|      |::..|.:..|.:.|   || |||     ..|..|....:
Frog   931 LEKQSRSQRHSLSSGHKLMNIGPGGPILSRQHSLGQGNRQ---HP-PPPLLTRMHSTGTPVPMES 991

  Fly   950 RSPMIGR--TYAKSMPVTPVQPQSPLA---ETPSYELYERHS---DAATFHF 993
            .|..:.|  :|.:..|::....:..|:   :.||..::...|   |||.|.:
Frog   992 HSVFLSRQLSYQEQTPMSRSMVKRTLSLRPDVPSNSVFLPSSPVKDAAQFKY 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	171/483 (35%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/40 (35%)
sema6c	XP_002937315.2	Sema_6E	50..511	CDD:200531	172/490 (35%)
sema6c	XP_002937315.2	PSI	512..>533	CDD:214655	9/22 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm9356
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010