DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema3b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001120908.1	Gene:	sema3b / 100151737	XenbaseID:	XB-GENE-921561	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	772	Identity:	215/772 - (27%)
Similarity:	342/772 - (44%)	Gaps:	100/772 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVG------NESVVDHFKLVTKDGNSLL 108
            :.:.|||...:||:     ..:.|:|  :|..:|::...|      ..|.......:.::...|.
Frog     8 LSLCLLLYFGLIGS-----NKVTPRL--KLSYQDLMSLHGLRTFTLERSCCYDALFLDEERGRLF 65

  Fly   109 IGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGT 171
            :|.:|.:.:||:.::.:|:..: |.:|.:..:.|...|||... |.||::|:...:...||.|||
Frog    66 VGGKNYLMSLSLDNISKQELAIHWPAPVEWREECNWAGKDINVDCMNYVKILQPYNRTHLFTCGT 130

  Fly   172 NSFRPMCNTYII----SDSNYTLEATK--NGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDP 230
            .:|.|.|....:    .|:.:.::..:  :|:..|||||:|.:.:||..:|||||...|..|.|.
Frog   131 GAFHPTCGFVHVGQRTDDTVFKMDLRRMEDGKGRCPYDPKHIAAAVLVGDELYSGVATDLMGRDF 195

  Fly   231 IIYRE-----PLQTEQYDSLSLNAPNFVSSF-------TQGDFVYFFFRETAVEFINCGKAIYSR 283
            .|:|.     ||:|||:||..||.|.||..|       ...|.:||||:||.||.....|..|:|
Frog   196 TIFRSLGRRPPLRTEQHDSRWLNEPKFVKVFWIPESENPDDDKIYFFFKETPVEGAGGVKQSYAR 260

  Fly   284 VARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDY---PFYFNEIQSASNLVEGQYGSMSSKLIY 345
            :.::|:.|.||.....|:||:|||:||.||:||:.   ..:|:|::....|   |.....:.|||
Frog   261 IGQICRNDLGGQRSLVNKWTTFLKARLVCSVPGNEIGGDTHFDELRDVFLL---QTRDRRNPLIY 322

  Fly   346 GVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC-------H 403
            .:|:|.|:...|||:|.:.:.|:...|.|.|..:.|.|..|:.. ..|||.||||.|       .
Frog   323 ALFSTSSSVFRGSAICVYTMNDVRRAFLGPFAHKEGPNYQWVSY-QGKVPYPRPGMCPSKTFGSF 386

  Fly   404 NDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVG 468
            ..:::.||..|.|.:.|.||...|.....:|:.:|:.....|||:|||......|  .|||:|:|
Frog   387 ESTKSFPDDVLQFARNHPLMFNPVVPGSGRPVFLRSHGDLSFTQLAVDRVAAADG--EYDVMFIG 449

  Fly   469 TDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIV 533
            ||.|.::|.::... .|...|..||:||:.|...:.||..::|....|            ::.:.
Frog   450 TDVGSVLKVISVPK-QSWHHVEQVVLEELQVFKNASPITTMQISSKRQ------------QIYVG 501

  Fly   534 TDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWL---EENYFYQNVATG 595
            :.|.:..:.|||| .....:|:||...:|||||||  ...|     .|:|   :.....|:|..|
Frog   502 SASGISQLPLHRC-GIYGKACAECCLARDPYCAWD--GASC-----TRFLPNTKRRSRRQDVRNG 558

  Fly   596 QHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTV 660
            ......||:............|.......|:...:|...::.....|   .|:.|...:.....|
Frog   559 DPNTLCSGEQQRFSVQEKRLLGVEGSSIFLECLPKSLRAQVTWTYQK---APESSRTEVQFDERV 620

  Fly   661 ETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDED-----------DNLPYPDTEYEYFEQRQNVN 714
            ......::..::.....|.|.       |:..|.           :.:|...||.....||...|
Frog   621 LQTDRGIVVRNVLRRDAGTFI-------CYSSEHGFTQTLLRLHLEVIPSSRTEEHLGLQRVPHN 678

  Fly   715 S-FPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPP-PPNKMHSPKNTLRK----PPMH 765
            . :....|:.|:|..:.|:.|..:........|| |....|.|.:..|.    ||::
Frog   679 RWYQDFMRLVQQPGSVEQMCEEIWTRKGRTSHPPGPQGAPHVPGSQGRSLPAVPPLN 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	155/484 (32%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
sema3b	NP_001120908.1	Sema_3B	43..514	CDD:200511	155/489 (32%)
		PSI	513..550	CDD:214655	15/44 (34%)
		Ig	575..663	CDD:299845	11/97 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020