DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema6bb

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_021327709.1	Gene:	sema6bb / 100148883	ZFINID:	ZDB-GENE-081105-129	Length:	874	Species:	Danio rerio

Alignment Length:	942	Identity:	275/942 - (29%)
Similarity:	401/942 - (42%)	Gaps:	240/942 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 HFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQ-----RLVWTSPEDDTKMCLVKGKDEEACQNYI 155
            |.:.:.:...:|.||||:.:|.:.:.::|.::     :..|.|.::|.::|.:|||.|:.|:||:
Zfish    58 HIQRILQVNRTLYIGARDDLFRVELDNVVGEEMFYSKKRTWESNKNDIRICRMKGKHEDECRNYM 122

  Fly   156 RIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLE---ATKNGQAVCPYDPRHNSTSVLADNEL 217
            ::: :...|.||:||||:|.|:|..|    :..|||   .|.:|.|.|||||:|.:.::.|:..|
Zfish   123 KVL-LSRQGGLFICGTNAFNPLCANY----TGDTLEMVGETVSGMARCPYDPKHANVALFAERNL 182

  Fly   218 YSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCG 277
            |:.||.||...|.:|||.     .|:|.::||.....|.|||:...|..|||||||.|:||....
Zfish   183 YTATVTDFLAIDAVIYRSLGDNPALRTVKHDSKWFREPYFVSAVEWGPHVYFFFREMAMEFNYLE 247

  Fly   278 KAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSS 341
            |.:.||||||||.|:||..| ...:||||||:|||||||||..||||.:.|.|.::. .:|   .
Zfish   248 KVVVSRVARVCKADQGGSQRVLEKQWTSFLKARLNCSIPGDSHFYFNLLHSTSPIIR-MHG---R 308

  Fly   342 KLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC---- 402
            .:|..||:||||||||||||||.::.:|..|:|:||||....|.|.||.:..:|.||||.|
Zfish   309 DIILAVFSTPSNSIPGSAVCAFDMEQLAGVFDGRFKEQKSPESIWTPVPDEALPKPRPGGCAVQG 373

  Fly   403 --HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVI 465
              .|.|.:.||..|.|:|||.||||.||:...:|.:|||...|:..::.||......|.:|  |:
Zfish   374 SKFNSSNSFPDDMLTFVKTHPLMDEAVPSLGQRPWIVRTMVRYQLNKMVVDTNAGPYGNQT--VL 436

  Fly   466 FVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVL------TKSEPIRNLEIVRTMQYDQPKDGS 524
            |:|:..|.|:|.:...:.|:.....:|.:||.:..      |.|...|.|   .::..|:...
Zfish   437 FLGSSRGTILKFLVTPNRDNTVTNNNVFLEEFEGYNPDRCGTDSPQARQL---LSLTLDRISH-- 496

  Fly   525 YDDGKLIIVTDSQVVAIQLHRCHNDKITSC-SECVALQDPYCAWDKIAGKCRSHGAPRWLEENYF 588
                .|::...|.|:.:.:.||  ...::| ..|:|.:||||.|
Zfish   497 ----SLLLTFPSCVIKVPVARC--QLYSACMKNCIASRDPYCGW--------------------- 534

  Fly   589 YQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISA-- 651
                        .:|.|.| ...||.:..|..|::      |.....:.|     .:|||...
Zfish   535 ------------TTGDICS-FLRAGTRLPFEQDVE------QGNTSHLGD-----CDGPQQGRFI 575

  Fly   652 ----DIINAQYTVETLVMAVLAGSIFS-LLVGFF-----------TGYFCGRRCHKDEDDNL--- 697
                .:::....|.:.|.|...|:..| |:|.:.           .|...|.|...|::.::
Zfish   576 EEPDGLVSVNLLVVSAVSAFATGAALSGLMVCWIMSLKHRQRSRANGSGLGSRRKSDKEQSMLGH 640

  Fly   698 ---------------PYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPP 747
                           ..|.::.|    ....|.:|.|..|...   ||..|           |.|
Zfish   641 GRSGSVISVTRISGSERPRSQIE----NMFTNGWPKSGEIDTG---LPTPE-----------QTP 687

  Fly   748 PPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQ---PDGYNTQQSYRGRDNFGTLRSHQVMGDNY 809
            ...|..||...|......|.|       .|..|   |...|:...|        |.|..:.|..
Zfish   688 LQQKRPSPNVHLTDCDWDQSH-------TFLAQTGTPCPANSAIIY--------LSSKYLQGGR- 736

  Fly   810 RRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHG-----IVTQHRSNSPQQQQQQSQQPHSS 869
            :.|.|                          ..|.|.     ::..|    |..|::|..:|
Zfish   737 QEGSG--------------------------DVPPHSERQRYLILAH----PPNQREQGSRP--- 768

  Fly   870 SGSSPVMSNSSSS---PAPPSSSPSPQE--SPKNCSYIY-------RDXLICNTKSMPLIQAQST 922
              |:|...||:..   ||.|..||..:.  |.......|       ||.|..|          |.
Zfish   769 --SAPPTRNSTGEYNYPATPQDSPDRRRVVSAPTTQSDYGEQLRWSRDGLNFN----------SN 821

  Fly   923 HAQPHPQSHPHPLPPPGPTTPPAQPRARSPMI 954
            :|.| ...||:|:          |||..:.:|
Zfish   822 NATP-SNHHPYPI----------QPRTNAALI 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	183/475 (39%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	10/34 (29%)
sema6bb	XP_021327709.1	Sema	49..512	CDD:326631	183/473 (39%)
sema6bb	XP_021327709.1	PSI	513..571	CDD:214655	21/104 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1228
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm6502
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960