DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and dvl3

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001116929.1	Gene:	dvl3 / 100144702	XenbaseID:	XB-GENE-977362	Length:	713	Species:	Xenopus tropicalis

Alignment Length:	810	Identity:	158/810 - (19%)
Similarity:	254/810 - (31%)	Gaps:	291/810 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 ISDSNYTLEATKNGQAVC----PYDPRHNSTSVLADNEL-------YSGTVADFSGSDPIIYREP 236
            |||.|..|... ||:.||    ....:.::.||.|||:.       .:|.:.|   |.|..:...
Frog    60 ISDDNAKLPCF-NGRVVCWLVSADGSQSDAGSVCADNQSDLPPPIERTGGIGD---SRPPSFHPN 120

  Fly   237 LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGP-HRFRN 300
            .:..|.:         :.:.|:.|.|....||              |..|     |..| |..|.
Frog   121 TRGSQEN---------LDNETETDSVVSAHRE--------------RPRR-----KETPEHATRL 157

  Fly   301 RWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFAL 365
            ..||.::.|.:   .|.|       :|:|.|       |||:|
Frog   158 NGTSKMERRRD---TGGY-------ESSSTL-------MSSEL---------------------- 183

  Fly   366 QDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPD-PTLNFIKTHSLMDENVPA 429
             |....|:....:.|...||....::|.    |....|...|..|. |.:....:.|.:.::.
Frog   184 -DSTSFFDSDEDDSTSRFSNSTEQSSAS----RLMRRHKRRRRKPKAPRIERSSSFSSITDST-- 241

  Fly   430 FFSQPILVRTSTI--YRFTQIAVDAQI--KTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVT 490
             .|..|:..|..:  |.|..|::..|.  :..||     |::|:    |:|. .|.:||...:..
Frog   242 -MSLNIITVTLNMEKYNFLGISIVGQSNERGDGG-----IYIGS----IMKG-GAVAADGRIEPG 295

  Fly   491 SVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSC- 554
            .::::..|  |..|.:.|.:.||.::....|.|.              :.:.:.:|.:....:|
Frog   296 DMLLQVND--TNFENMSNDDAVRVLREIVHKPGP--------------ITLTVAKCWDPSPRNCF 344

  Fly   555 ----SECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAA---CPS-GKINSKDAN 611
                ||.:...|| .||       .||.|            ..||.:.|   .|| ..|.|..::
Frog   345 TLPRSEPIRPIDP-AAW-------VSHTA------------AMTGSYPAYGMSPSMSTITSTSSS 389

  Fly   612 AGE-----------QKGFRNDMDLL-------DSRRQSKDQ--------------EIIDNIDKNF 644
            ...           |....:||..:       :|..:.:|:              :::|.:..:.
Frog   390 ITSSIPETERFDDFQLSIHSDMVTIVKAMRSPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHHV 454

  Fly   645 EG-------PQISADIINAQY---TVETLVMAVLAGSIFSLLVGFFTGYFCGRRCH--------- 690
            ||       .:.:::::.|.|   ||..:.        ||....:..|..||...:
Frog   455 EGFTDRREARKYASNLLKAGYIRHTVNKIT--------FSEQCYYIFGDLCGNMANLSLNDHDGS 511

  Fly   691 ---KDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKM 752
               .|:|...|.|                        .|...|......|..|  ||.|
Frog   512 SGTSDQDTLAPLP------------------------HPGAAPWPIAFQYQYP--LPHP------ 544

  Fly   753 HSPKNTLRKPPMHQMHQG-PNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVM--------GDN 808
            :||            |.| |  :..:.:......:|.| .|..:.|:.||....        ||.
Frog   545 YSP------------HPGFP--DPAYSYGGGSAGSQHS-EGSRSSGSNRSSTEKRKEREAKGGDT 594

  Fly   809 YRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSG-- 871
            ...|.|..:..:.:.:|.    |.|:..........|    .|||:.......:|...|.|.|
Frog   595 KSGGSGSESDHTTRSSVR----RERAASERSVPASEH----SHRSHHSIAHSIRSHHTHHSFGPP 651

  Fly   872 ------SSPVMSNSSSSPA----PPSSSPS 891
                  .:|:|  ...:||    ||.:.||
Frog   652 GIPPLYGAPMM--MMPAPASVIGPPGAPPS 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	78/379 (21%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	10/38 (26%)
dvl3	NP_001116929.1	DAX	1..82	CDD:197474	9/22 (41%)
		Dishevelled	87..244	CDD:367060	45/234 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..235		44/222 (20%)
		PDZ_signaling	246..333	CDD:238492	23/112 (21%)
		DEP_dishevelled	413..495	CDD:239885	11/89 (12%)
		Dsh_C	499..701	CDD:372040	45/238 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..527		4/42 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..652		26/129 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm9356
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000