DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema3bl

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001116184.1	Gene:	sema3bl / 100004611	ZFINID:	ZDB-GENE-030131-2956	Length:	771	Species:	Danio rerio

Alignment Length:	866	Identity:	229/866 - (26%)
Similarity:	370/866 - (42%)	Gaps:	181/866 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVD------HFKLVTKD--GNSLLIG 110
            |:|..||:...|..:.|: |:|  .|..:|:|. ....||.:      |...|..|  .:.|.:|
Zfish     6 LVLVALVLPLSSCTKVNV-PRL--RLTHKDLLD-TNRTSVFNGLHGDLHLSAVFLDEYHDRLFLG 66

  Fly   111 ARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEE-ACQNYIRIMVVPSPGRLFVCGTNSF 174
            .::.:::|.:....:.:.:.|.|...:.:.|::||||.| .|.|::|::...:...|..|||.:|
Zfish    67 GKDVLYSLRLDHTHDAKEIHWPSLPGNREDCILKGKDPEMECANFVRLLQPFNRTHLLACGTGAF 131

  Fly   175 RPMC---NTYIISDSNYTLEAT--KNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPII-- 232
            :|:|   |.....:..::|:.|  :||:..||:||:....|.....|||:|..|||.|.|.:|
Zfish   132 QPVCAYVNVGHRGEHVFSLDQTTVQNGRGRCPHDPKLPFASTFTGGELYTGLTADFLGRDSVISR 196

  Fly   233 ---YREPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFI--NCGKAIYSRVA 285
               .|.|::||. |...|:.|.||       |:....|.:||||.|.|.|..  :...||::|:.
Zfish   197 GFGTRSPMRTET-DQRILHEPRFVAAHLIPDSADRDDDKIYFFFTERATETAERDDDGAIHTRIG 260

  Fly   286 RVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPF--YFNEIQSASNLVEGQYGSMSSKLIYGVF 348
            |:|..|.||.....|:|::|:|:||.||:||.:..  :|::::....|   :....::..||.:|
Zfish   261 RLCANDVGGQRVLVNKWSTFIKARLVCSVPGPHGIQTHFHQLEDVFLL---RTKDETNPEIYAIF 322

  Fly   349 NTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRA----- 408
            :|.||...|.|||.:::.||.:.|.|.|..:.|.:..|.|. ..:||.||||.|.:...|
Zfish   323 STISNVFQGYAVCVYSMADIREAFNGPFAHKEGPDYQWGPY-EGRVPYPRPGVCPSKITAQPGRA 386

  Fly   409 ------LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFV 467
                  .||..|.|.:||.||...|.....||:|:||...||.|.|.||......|  .|||:|:
Zfish   387 FRSTLEFPDTVLQFARTHPLMWRPVYPSHRQPLLLRTGAPYRLTHITVDRTQAEDG--YYDVMFI 449

  Fly   468 GTDHGKIIKSVNAESADS--ADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKL 530
            |||.|.::|.:.....:|  .:::|   :||:.|.....||.:::|            |.....|
Zfish   450 GTDIGTVLKVIVLGKGNSLAGEEIT---LEEMQVFKVPTPITSMDI------------SVKRQTL 499

  Fly   531 IIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATG 595
            .:.:.:.||.:.|||| :....:|:||...:|||||||   |:..:...|. .:..|..|::
Zfish   500 FVGSQTAVVQVPLHRC-SMYGKACAECCLARDPYCAWD---GQTCTRYLPN-TKRRYRRQDI--- 556

  Fly   596 QHA----ACPSGKINSKDANAGEQK---GFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADI 653
            :||    .|....::.:|.:..|::   |..|:...|:...:|....:..:|.:         |.
Zfish   557 KHANPAVQCMDQNLSVEDVDLSEERVVYGTENNSTFLECVPRSPQATVTWHIQR---------DD 612

  Fly   654 INAQYTVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCH---------------KDEDDNLPYPDT 702
            ...:...:..::....|.:|..::....| |.|..|.|               .|...:|...|:
Zfish   613 YLGEVVFDERIIKTDDGLLFRRVLRQDEGIYVCRSREHGFTQTLSRFWLDVLNADTLSDLLSRDS 677

  Fly   703 EYEYFE----QRQNVNSFPSSCRIQQ-----EPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNT 758
            :|:.:.    ....:|..|:....:.     .|..|||||:  |.|.|..            ...
Zfish   678 KYKVWSPCPANSATMNRGPARAWFKDVLQLIGPSNLPQVEQ--YCERVWC------------NEK 728

  Fly   759 LRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKK 823
            ||                                       |.|:.|.|.||:....:....|:|
Zfish   729 LR---------------------------------------RKHKSMMDKYRQAQDSARRARVQK 754

  Fly   824 AVNNTNTRNRSLGRARRQPPR 844
                      |.|.:|.:.||
Zfish   755 ----------STGESRHRSPR 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	154/497 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
sema3bl	NP_001116184.1	Sema_3G	42..515	CDD:200516	152/494 (31%)
		PSI	514..>550	CDD:214655	14/40 (35%)
		Ig_Semaphorin_classIII	579..664	CDD:143279	14/93 (15%)
		IG_like	581..663	CDD:214653	13/90 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910