Protein Alignment IDH3A and IDH2

DIOPT Version :10

• Sequence 1: NP_005521.1
• Gene: IDH3A / 3419
• HGNCID: 5384
• Length: 366
• Species: Homo sapiens
• Sequence 2: NP_014779.1
• Gene: IDH2 / 854303
• SGDID: S000005662
• Length: 369
• Species: Saccharomyces cerevisiae
• Alignment Length: 353
• Identity: 192/353 - (54%)
• Similarity: 244/353 - (69%)
• Gaps: 13/353 - (3%)

Human    21 KQVTRG-FTG------GVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKW 78
            ||.:.| :||      |..||:.|.|||||||||.:|.|||.||..||:||..:|:.| ...|..
Yeast    19 KQPSIGRYTGKPNPSTGKYTVSFIEGDGIGPEISKSVKKIFSAANVPIEWESCDVSPI-FVNGLT 82

Human    79 MIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIV 143
            .||..|.:|:.||.:.|||||.|||..||.|:||.|||||.|:|||||..||||:||.|.:|::|
Yeast    83 TIPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTYENVDLV 147

Human   144 TIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSD 208
            .||||||||||||||::..||||||||||..||:|:..:||||||...|..|..|||:.|.|::|
Yeast   148 LIRENTEGEYSGIEHIVCPGVVQSIKLITRDASERVIRYAFEYARAIGRPRVIVVHKSTIQRLAD 212

Human   209 GLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFD--VLVMPNLYGDILSDLCAGL-IGGL 270
            |||:...:|:::...|:......:|...|.:|.:||.:.  |.|.|||||||||||.:|| .|.|
Yeast   213 GLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSVCPNLYGDILSDLNSGLSAGSL 277

Human   271 GVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATI 335
            |:|||.||| :.::|||:|||:||||||:|.|||||||||:||||.||||.:||.:|:.|..:||
Yeast   278 GLTPSANIG-HKISIFEAVHGSAPDIAGQDKANPTALLLSSVMMLNHMGLTNHADQIQNAVLSTI 341

Human   336 KDG-KSLTKDLGGNAKCSDFTEEICRRV 362
            ..| ::.|.||.|.|..|.|||.:.:|:
Yeast   342 ASGPENRTGDLAGTATTSSFTEAVIKRL 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH3A	NP_005521.1	mito_nad_idh	29..362	CDD:272942	187/342 (55%)
IDH2	NP_014779.1	Iso_dh	34..369	CDD:444908	186/336 (55%)