DRSC/TRiP Functional Genomics Resources

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Protein Alignment IDH3A and Idh3b

DIOPT Version :9

Sequence 1:NP_005521.1 Gene:IDH3A / 3419 HGNCID:5384 Length:366 Species:Homo sapiens
Sequence 2:NP_001163682.1 Gene:Idh3b / 42586 FlyBaseID:FBgn0038922 Length:370 Species:Drosophila melanogaster


Alignment Length:343 Identity:144/343 - (41%)
Similarity:207/343 - (60%) Gaps:11/343 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    22 QVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKE 86
            :.|..:.....|.|||||||:|||:..::.::|.||..|:.:|...::.|..     ::.::.::
  Fly    28 RATDNYGANRTTCTLIPGDGVGPELVYSLQEVFKAASVPVDFECYFLSEINP-----VLSAKLED 87

Human    87 ---SMDKNKMGLKGPLKTP---IAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTI 145
               |:.|||:.:||.|.||   ......::|:.||...||||||....|:.|.||.:|:::.|.|
  Fly    88 VVASIQKNKVCIKGVLATPDYSNVGDLQTLNMKLRNDLDLYANVVHVRSLPGVKTRHTNIDTVII 152

Human   146 RENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGL 210
            ||.||||||.:||..|.|:|:.:|:||...|.|||:|||:||..|.|..||||||||||::.|||
  Fly   153 REQTEGEYSALEHESVPGIVECLKIITAKKSMRIAKFAFDYATKNQRKKVTAVHKANIMKLGDGL 217

Human   211 FLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPS 275
            ||:.|.||:.....|:|.:|.:|...:.||.:|:||||:|.|||||.|:.:|.:||:||.||...
  Fly   218 FLRSCEEVSRLYPRIQFEKMIVDNTTMQMVSNPNQFDVMVTPNLYGAIVDNLASGLVGGAGVVAG 282

Human   276 GNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKS 340
            .:..:..|........|..:..||::|||||:||..|.:|||:.|..:...|:.|....:.|||.
  Fly   283 ASYSSESVVFEPGARHTFAEAVGKNVANPTAMLLCGVKLLRHINLPTYGEIIQNAINKVLNDGKV 347

Human   341 LTKDLGGNAKCSDFTEEI 358
            .||||||.:...|||..|
  Fly   348 RTKDLGGQSTTQDFTRAI 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IDH3ANP_005521.1 mito_nad_idh 29..362 CDD:272942 143/336 (43%)
Idh3bNP_001163682.1 Iso_dh 37..369 CDD:294303 143/334 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0473
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53770
OrthoDB 1 1.010 - - D325037at33208
OrthoFinder 1 1.000 - - FOG0000244
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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