Protein Alignment IDH3A and idha-1

DIOPT Version :10

• Sequence 1: NP_005521.1
• Gene: IDH3A / 3419
• HGNCID: 5384
• Length: 366
• Species: Homo sapiens
• Sequence 2: NP_492330.2
• Gene: idha-1 / 172655
• WormBaseID: WBGene00009664
• Length: 358
• Species: Caenorhabditis elegans
• Alignment Length: 360
• Identity: 249/360 - (69%)
• Similarity: 280/360 - (77%)
• Gaps: 7/360 - (1%)

Human     7 ISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAI 71
            |.|.|..:|      |..|..:|.|:.|||||||||||||||:|.|||:||.|||.|:..:||.:
 Worm     6 IKKASSTVG------QSIRYSSGDVRRVTLIPGDGIGPEISASVQKIFEAADAPIAWDPVDVTPV 64

Human    72 QGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTP 136
            :|..|.:.|||...|.|..||:||||||:|||..||.|:||.:||.|.||||||||.|:||:||.
 Worm    65 KGRDGVFRIPSRCIELMHANKVGLKGPLETPIGKGHRSLNLAVRKEFSLYANVRPCRSLEGHKTL 129

Human   137 YTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKA 201
            |.:|::||||||||||||||||.||.|||||||||||.||:.:|.|||||||.|.|..|||||||
 Worm   130 YDNVDVVTIRENTEGEYSGIEHEIVPGVVQSIKLITETASRNVASFAFEYARQNGRKVVTAVHKA 194

Human   202 NIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGL 266
            ||||.||||||..|||.|....||||.|.|||||||||||||||:||||||||||||||||||||
 Worm   195 NIMRQSDGLFLSICREQAALYPDIKFKEAYLDTVCLNMVQDPSQYDVLVMPNLYGDILSDLCAGL 259

Human   267 IGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAAC 331
            :|||||||||||| .|.|:|||||||||||||:|.|||||||||||||||:|.|..||||||.|.
 Worm   260 VGGLGVTPSGNIG-KGAAVFESVHGTAPDIAGQDKANPTALLLSAVMMLRYMNLPQHAARIEKAV 323

Human   332 FATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD 366
            |..|.||::.|.||||...||.||.::|.|||||:
 Worm   324 FDAIADGRAKTGDLGGTGTCSSFTADVCARVKDLE 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH3A	NP_005521.1	mito_nad_idh	29..362	CDD:272942	238/332 (72%)
idha-1	NP_492330.2	Iso_dh	22..354	CDD:444908	238/332 (72%)