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Protein Alignment Acer and ACE2

DIOPT Version :9

Sequence 1:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001358344.1	Gene:	ACE2 / 59272	HGNCID:	13557	Length:	805	Species:	Homo sapiens

Alignment Length:	616	Identity:	219/616 - (35%)
Similarity:	331/616 - (53%)	Gaps:	24/616 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WLPHGLSMGNSCSASVLE-ARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNA 79
            ||...|....:..:::.| |:.|.:..|.:....|::..|:.:|||||:||.|.|.|.....:.:
Human     6 WLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWS 70

  Fly    80 ELNKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSY 144
            ...|..:...:.....:.::..::.|.:.|.:.|:|.|:.|....|...:::|.|.|:|..||:.
Human    71 AFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNP 135

  Fly   145 TNRSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSY 209
            .|..:| |.|||.:.|.:::|.|..|..|.|..|..:.|..:|..:.|||.|..:.::.|.:..|
Human   136 DNPQEC-LLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDY 199

  Fly   210 ADYWVQFYE-----DPDFER-----QLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIP 264
            .|||...||     ..|:.|     .::.||:::.|.|..||.|||.:|...| |..:...|.:|
Human   200 GDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAY-PSYISPIGCLP 263

  Fly   265 ISLLGNMWGQSWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFW 329
            ..|||:|||:.|..|..|..|:.:||.:||...|..|.:..|::|:..::||.|:|:..:...||
Human   264 AHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFW 328

  Fly   330 NLSVLTRPDD-RHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVY 393
            ..|:||.|.: :..|||.:|||..: .|.||.|||:|....|...|||:|||||.:.|..||.:.
Human   329 ENSMLTDPGNVQKAVCHPTAWDLGK-GDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLL 392

  Fly   394 RGAPNPGFHEAVGDVIALSVMSAKHLKAIGLIE-NGRLDEKSRINQLFKQALSKIVFLPFGYAVD 457
            |...|.|||||||::::||..:.||||:|||:. :.:.|.::.||.|.||||:.:..|||.|.::
Human   393 RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLE 457

  Fly   458 KYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQ 522
            |:|:.||:.|:.:.||...:|:|:.|..||..||...|...||.:.:|:..|..::||:...::|
Human   458 KWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQ 522

  Fly   523 FQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDP 587
            |||.:|||:.|....|      |..|||..|..||:.|...|..|.|..|...||...|...|:.
Human   523 FQFQEALCQAAKHEGP------LHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNV 581

  Fly   588 AALLEYFEPLYQWLKQE--NSRLGVPLGWGP 616
            ..||.|||||:.|||.:  ||.:|....|.|
Human   582 RPLLNYFEPLFTWLKDQNKNSFVGWSTDWSP 612

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.