DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acer and Ace3

DIOPT Version :9

Sequence 1:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001245166.1	Gene:	Ace3 / 498012	RGDID:	1561299	Length:	737	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	236/612 - (38%)
Similarity:	348/612 - (56%)	Gaps:	16/612 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLVIMLW---LPHGLSMGNSC---SASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANR 68
            |||::.:   ||...::|...   ..|..:|:.|.:...:..|...:|...:.:||.||:|:.|:
  Rat     8 LLVLLYYGQPLPWPKTVGEPSLDEFYSEAQAKMFLQFYEQTARVVLNELMEATWNYVTNITKQNQ 72

  Fly    69 QAMIEVYARNAELNKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQ 133
            :.|::.....::.......:.:.......:|.|::|:...|..:..|||..:|:......::.|:
  Rat    73 ENMLQKEVERSQFMLYFGTRARMFRIDHFQDLDVKRRLSKLRNIDKSALPVEDFQEFNRLLTYMK 137

  Fly   134 TNYATATVCSYTNRSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTR 198
            |.|..|.||  .:...| :.|||.::|.::.|||..||.|.|:.|.|..|..:|..|.:||.|:.
  Rat   138 TAYGRAEVC--LDEGPC-MPLEPDLEEIMATSRDQKELLWAWQGWRDAIGRQLRPVFEDYVHLSN 199

  Fly   199 KASQLNGHRSYADYWVQFYEDPDFERQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNI 263
            ||:|.||::.....|...||....|..|:..:|:|.|.|..||.|||..|.::|||:::...|.|
  Rat   200 KAAQYNGYKDMGALWRSKYESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPI 264

  Fly   264 PISLLGNMWGQSWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSF 328
            |..||||||.||||.:|||..|||.||..|:...|:.|.:..:|:||..:.||.|:||...||:|
  Rat   265 PAHLLGNMWAQSWNNILDLVLPYPNKPPEDITKIMKNQHWRPEKMFEEANLFFTSMGMLPAPPAF 329

  Fly   329 WNLSVLTRP-DDRHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAV 392
            |..|::.:| |.|.|.||.|:|:||:.:|.|:|.||||.......:.|::||||||||.:....:
  Rat   330 WMKSMMEKPVDGREVECHTSSWNFYRLNDFRVKKCTEVTIGDLLSIFHQMGHIQYYLQCQNLSII 394

  Fly   393 YRGAPNPGFHEAVGDVIALSVMSAKHLKAIGLIENGRLDEKSRINQLFKQALSKIVFLPFGYAVD 457
            |:...:|.|.||||..|.||..|.|:|...||:.....|.:..:|.|...||.||.|:||||.:|
  Rat   395 YQEGASPAFEEAVGSTITLSAFSHKYLLTRGLLSQQHQDSEEEVNFLLSIALEKIAFIPFGYMID 459

  Fly   458 KYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQ 522
            .:|:.||...:.::.:|..:|.:|.::.|:.|||.|:|.||||.||:||.|::.|:|||.:.:.|
  Rat   460 LFRWKVFDGTIQKNAYNQEWWSLRLKYQGLCPPVPRSEDDFDPGAKFHIPANMPYIRYFLSLVLQ 524

  Fly   523 FQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDP 587
            ||.|:.|||.:|...|      |..|||:.||.||:.|..||..|:||.|:|||:|.||:..:..
  Rat   525 FQLHEVLCRASGHVGP------LHRCDIYNSKVAGKILGDFLKVGSSRPWQEVLKEITGKPNIST 583

  Fly   588 AALLEYFEPLYQWLKQENSRLGVPLGW 614
            .|||.||:||..||..||.:.|..|||
  Rat   584 KALLTYFKPLLNWLVTENVKQGDILGW 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	222/568 (39%)
Ace3	NP_001245166.1	Peptidase_M2	34..610	CDD:279709	228/584 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339579
Domainoid	1	1.000	532	1.000	Domainoid score	I271
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1420
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8935
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900