DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acer and ace2

DIOPT Version :9

Sequence 1:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_005169416.1	Gene:	ace2 / 492331	ZFINID:	ZDB-GENE-041114-6	Length:	818	Species:	Danio rerio

Alignment Length:	601	Identity:	225/601 - (37%)
Similarity:	340/601 - (56%)	Gaps:	20/601 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SCSASVLE-ARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNAELNKRLAQQI 89
            :|..:|.: ||.|....:|:.....::..|:.:.|||::::.|.....|.||..:|...:::::.
Zfish    15 ACCQTVEDRAREFLNKFDEEASDIMYQYTLASWAYNTDISQENADKEAEAYAIWSEYYNKMSEES 79

  Fly    90 KSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSYTNRSDCSLTL 154
            .:....|..|..|:.|.:.|...|:.||:.|....|:|.:|.|.|.|.|||||...:.:||. ||
Zfish    80 NAYPIDQISDPIIKMQLQKLQDKGSGALSPDKASELRNIMSEMSTIYNTATVCKIDDPTDCQ-TL 143

  Fly   155 EPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSYADYWVQFYE- 218
            ||.::..::.|||..|....|..|...:|..||..:.:||.|..:|::||.:..:.|||...||
Zfish   144 EPGLESIMAESRDYDERLHVWEGWRVATGMKMRPLYEKYVDLKNEAAKLNNYEDHGDYWRGDYET 208

  Fly   219 --DPDFERQLDAT-------FKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQ 274
              ||.:....|..       :|::||.|::||.|||.:|:..| |..:.::..:|..|||:|||:
Zfish   209 IDDPKYSYSRDQVIEDARRIYKEILPLYKELHAYVRAKLQDVY-PGHIGSDACLPAHLLGDMWGR 272

  Fly   275 SWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRPDD 339
            .|..|..|..|||::|.:||.:.|.:||:...:||:..::||.|:.|.|:..:|||.|:..:|::
Zfish   273 FWTNLYPLMIPYPDRPDIDVSSAMVEQGWDEIRLFKEAEKFFMSVNMPAMFDNFWNNSMFIKPEE 337

  Fly   340 RHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEA 404
            |.||||.:|||.....|.||||||:|:...|..||||:||.||.:.|...|.:.|...|.|||||
Zfish   338 RDVVCHPTAWDMGNRKDFRIKMCTKVNMDDFLTVHHEMGHNQYQMAYRNHPYLLRDGANEGFHEA 402

  Fly   405 VGDVIALSVMSAKHLKAIGLIENG-RLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNEL 468
            ||::::||..:..||:::||:.:. :.|.::.||.|.||||:.:..|||.|.::::|:.||:.::
Zfish   403 VGEIMSLSAATPSHLQSLGLLPSDFKQDYETDINFLLKQALTIVGTLPFTYMLEEWRWQVFKAKI 467

  Fly   469 DESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRKA 533
            .:.:|...:|||:.|..||...|.|.|...||||.:|:..|..::|||...|:||||.:|||:.|
Zfish   468 PKDEWMQQWWQMKRELVGVAEAVPRDETYCDPPALFHVSGDYSFIRYFTRTIYQFQFQEALCKAA 532

  Fly   534 GQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLY 598
            |...|      |..|||..|..||..|...|..|.|..|...|||..|.|:||...||.||..|.
Zfish   533 GHTGP------LYKCDITNSTKAGDKLRHMLELGRSMSWTRALEEVAGTTKMDSQPLLHYFSTLM 591

  Fly   599 QWLKQENSRLGVPLGW 614
            :|||:||.:.....||
Zfish   592 EWLKEENQKNNRVPGW 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	217/578 (38%)
ace2	XP_005169416.1	M2_ACE	27..598	CDD:188999	217/578 (38%)
ace2	XP_005169416.1	Collectrin	630..781	CDD:293564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1740
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830