DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Acer and Ace2

DIOPT Version :10

Sequence 1:NP_477195.1 Gene:Acer / 34189 FlyBaseID:FBgn0016122 Length:630 Species:Drosophila melanogaster
Sequence 2:NP_001012006.1 Gene:Ace2 / 302668 RGDID:728890 Length:805 Species:Rattus norvegicus


Alignment Length:624 Identity:236/624 - (37%)
Similarity:343/624 - (54%) Gaps:42/624 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 MGNSC-----SASVLEARRFFELENEQLRRRFHEE--------FLSGYNYNTNVTEANRQAMIEV 74
            |.:||     ..:|..|:...|.:.|....:|::|        .|:.:|||||:||.|.|.|.|.
  Rat     1 MSSSCWLLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENAQKMNEA 65

  Fly    75 YARNA---ELNKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNY 136
            .|:.:   |...::||.....:.   ::|.|:||.:.|.:.|:|||:.|....|...:::|.|.|
  Rat    66 AAKWSAFYEEQSKIAQNFSLQEI---QNATIKRQLKALQQSGSSALSPDKNKQLNTILNTMSTIY 127

  Fly   137 ATATVCSYTNRSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKAS 201
            :|..||:..|..:|.| |||.:.|.::.|.|.....|.|..|..:.|..:|..:.|||.|..:.:
  Rat   128 STGKVCNSMNPQECFL-LEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQLRPLYEEYVVLKNEMA 191

  Fly   202 QLNGHRSYADYWVQFYEDPDFE----------RQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDV 256
            :.|.:..|.|||...||....|          ..::.|||::.|.|.|||.|||.:|.:.| |..
  Rat   192 RANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYEQLHAYVRTKLMEVY-PSY 255

  Fly   257 MPAEGNIPISLLGNMWGQSWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGM 321
            :...|.:|..|||:|||:.|..|..|.||:.:||.:||...|..|.:..:::|:..::||.|:|:
  Rat   256 ISPTGCLPAHLLGDMWGRFWTNLYPLTTPFLQKPNIDVTDAMVNQSWDAERIFKEAEKFFVSVGL 320

  Fly   322 RALPPSFWNLSVLTRP-DDRHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQ 385
            ..:.|.||..|:||.| |||.||||.:|||. ...|.||||||:|....|...|||:|||||.:.
  Rat   321 PQMTPGFWTNSMLTEPGDDRKVVCHPTAWDL-GHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMA 384

  Fly   386 YEQQPAVYRGAPNPGFHEAVGDVIALSVMSAKHLKAIGLI-ENGRLDEKSRINQLFKQALSKIVF 449
            |.:||.:.|...|.|||||||::::||..:.||||:|||: .|.:.|.::.||.|.||||:.:..
  Rat   385 YAKQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGT 449

  Fly   450 LPFGYAVDKYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLR 514
            |||.|.::|:|:.||::::...||...:|:|:.|..||..|:...|...||.:.:|:..|..::|
  Rat   450 LPFTYMLEKWRWMVFQDKIPREQWTKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSNDYSFIR 514

  Fly   515 YFAAHIFQFQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEF 579
            |:...|:||||.:|||:.|....|      |..|||..|..||:.|...||.|||..|...||..
  Rat   515 YYTRTIYQFQFQEALCQAAKHDGP------LHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENV 573

  Fly   580 TGETEMDPAALLEYFEPLYQWLKQE--NSRLGVPLGWGP 616
            .|...||...||.||:||:.|||::  ||.:|....|.|
  Rat   574 VGSRNMDVKPLLNYFQPLFVWLKEQNRNSTVGWSTDWSP 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AcerNP_477195.1 Peptidase_M2 33..614 CDD:460196 230/605 (38%)
Ace2NP_001012006.1 Peptidase_M2 22..606 CDD:460196 228/595 (38%)
Collectrin 617..746 CDD:465322
Essential for cleavage by ADAM17. /evidence=ECO:0000250 652..659
Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000250 697..716
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..805
LIR. /evidence=ECO:0000250|UniProtKB:Q9BYF1 778..786
SH2-binding. /evidence=ECO:0000250|UniProtKB:Q9BYF1 781..785
Endocytic sorting signal. /evidence=ECO:0000250|UniProtKB:Q9BYF1 781..784
PTB. /evidence=ECO:0000250|UniProtKB:Q9BYF1 792..795
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9BYF1 803..805
Blue background indicates that the domain is not in the aligned region.

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