DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acer and Ace

DIOPT Version :9

Sequence 1:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_036676.1	Gene:	Ace / 24310	RGDID:	2493	Length:	1313	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	236/602 - (39%)
Similarity:	351/602 - (58%)	Gaps:	16/602 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LPHGLSMGNSCSASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNAEL 81
            ||.....|........:|.||.|..:...:..::|...:.::||||:|....:.:::   :|.|:
  Rat   638 LPDNYPEGIDLETDEAKANRFVEEYDRTAKVLWNEYAEANWHYNTNITIEGSKILLQ---KNKEV 699

  Fly    82 NK---RLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCS 143
            :.   :.....|:.|....:::.|:|..:.:..:..:.|..::.......:..|:|.|:.|.||
  Rat   700 SNHTLKYGTWAKTFDVSNFQNSTIKRIIKKVQNVDRAVLPPNELEEYNQILLDMETTYSVANVC- 763

  Fly   144 YTNRSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRS 208
            ||| ..| |:|||.:...::.||...||.|.|:.|.||.|..:...|.:||..:.|.::|||:..
  Rat   764 YTN-GTC-LSLEPDLTNIMATSRKYEELLWVWKSWRDKVGRAILPFFPKYVDFSNKIAKLNGYSD 826

  Fly   209 YADYWVQFYEDPDFERQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWG 273
            ..|.|...||..|.|:.|:..:::|.|.|..||.|||..|.:|||.:.:..:|.||..||||||.
  Rat   827 AGDSWRSSYESDDLEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWA 891

  Fly   274 QSWNELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRP- 337
            |:|:.:.||..|:|..|.:|....|.|||:|.:::|:..|.||.|||:..:||.|||.|:|.:|
  Rat   892 QTWSNIYDLVAPFPSAPSIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPT 956

  Fly   338 DDRHVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFH 402
            |.|.|||||||||||...|.|||.||.|:.....:.|||:|||||::||:..|..:|...|||||
  Rat   957 DGREVVCHASAWDFYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFH 1021

  Fly   403 EAVGDVIALSVMSAKHLKAIGLIENGRLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNE 467
            ||:|||:||||.:.|||.::.|:.:.....:..||.|.|.||.||.|:||.|.:|::|:.||...
  Rat  1022 EAIGDVLALSVSTPKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGS 1086

  Fly   468 LDESQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRK 532
            :.:..:|..:|.:|.::.|:.|||.|::.||||.:|:|:.|:|.|:|||.:.|.|||||:||||.
  Rat  1087 ITKENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYIRYFISFIIQFQFHEALCRA 1151

  Fly   533 AGQYAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPL 597
            ||...|      |..|||:.||.||:.|:..:..|.|:.|.|.::..||:..|..:|::.||:||
  Rat  1152 AGHTGP------LYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPL 1210

  Fly   598 YQWLKQENSRLGVPLGW 614
            .:||..||.|.|..|||
  Rat  1211 TEWLVTENRRHGETLGW 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	224/571 (39%)
Ace	NP_036676.1	Peptidase M2 1	36..636
		Peptidase_M2	46..629	CDD:279709
		Peptidase M2 2	637..1238		236/602 (39%)
		Peptidase_M2	650..1227	CDD:279709	231/588 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	532	1.000	Domainoid score	I271
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1420
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8935
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830