DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acer and Ace3

DIOPT Version :9

Sequence 1:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_006533116.1	Gene:	Ace3 / 217246	MGIID:	3644400	Length:	774	Species:	Mus musculus

Alignment Length:	641	Identity:	249/641 - (38%)
Similarity:	358/641 - (55%)	Gaps:	44/641 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NITVLLLVIML----WLPHGLSMGNSC---SASVLEARRFFELENEQLRRRFHEEFLSG-YNYNT 61
            |:...||:::|    .||...::|.:.   ..|..:|:.|.:. .||..:....||:.. :||.|
Mouse    20 NLPWALLLVLLSHRQLLPWLRTVGETSLNDFYSEAQAKLFLQF-YEQTAQVVLNEFMEATWNYVT 83

  Fly    62 NVTEANRQAMIEVYARNAELN---KRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYL 123
            |:|:.|::.|::..|..::..   ...|:..::..::   :.|::|....|..:..|||..:|.|
Mouse    84 NITKQNQKNMLQKEADRSQFMLYFSTRARMFRTDHFL---NQDVKRMLRKLQNIDKSALPTEDLL 145

  Fly   124 AL-------------------QNAISSMQTNYATATVCSYTNRSDCSLTLEPHIQERLSHSRDPA 169
            .:                   ...::.|:|.|..|.||  .:...| |||||.:||.::.|||..
Mouse   146 EVTDRGPGRPGTHTPAPERRYNRLLTYMETAYNRAEVC--LDEGPC-LTLEPDLQEIMATSRDQK 207

  Fly   170 ELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSYADYWVQFYEDPDFERQLDATFKQLL 234
            ||.|.|:.|.|..|..:|..|.:||||:.||:|.||::.....|...||....|..|:..:|:|.
Mouse   208 ELLWAWQGWRDAVGRQLRPVFEDYVRLSNKAAQYNGYKDMGALWRSKYESDTLEEDLEQLYKELQ 272

  Fly   235 PFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQSWNELLDLFTPYPEKPFVDVKAEME 299
            |.|..||.|||..|.::|||:::...|.||..||||||.||||.:|||..|||.|...|:.|.|:
Mouse   273 PLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNMWAQSWNNILDLVLPYPTKAPEDITAIMK 337

  Fly   300 KQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRP-DDRHVVCHASAWDFYQDSDVRIKMCT 363
            .|.:..:|:||..:.||.|:||...||:||..|::.:| |.|.|.||.|:|:||:.:|.|:|.||
Mouse   338 IQHWRPEKMFEEANLFFTSMGMLPAPPAFWIKSMMEKPADGREVECHTSSWNFYKFNDFRVKKCT 402

  Fly   364 EVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEAVGDVIALSVMSAKHLKAIGLIENG 428
            ||.......|.|::|||||:|||:....:|:...:|.|.||||.||||||.|.|:|.|.||:...
Mouse   403 EVTLEDLLSVFHQMGHIQYFLQYQNLSVIYQEGASPAFEEAVGSVIALSVSSHKYLLARGLLSQP 467

  Fly   429 RLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFR 493
            ..|.:..:|.|...||.||.|:||.|.|||:|:.:|...:.:..:|..:|..|.::.|:.|||.|
Mouse   468 HQDSEEEVNFLLGIALEKIAFIPFSYLVDKFRWKIFDGTISKITYNQEWWNFRLKYQGLCPPVPR 532

  Fly   494 TEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGR 558
            ::.||||.||:||.|:|.|:|||...|.|||.|:|||..:|...|      |..||.:.||.||:
Mouse   533 SDDDFDPGAKFHIPANVPYIRYFLGLILQFQLHEALCEASGHVGP------LHQCDNYNSKVAGK 591

  Fly   559 SLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLYQWLKQENSRLGVPLGW 614
            .|...|..|:||.|:|||:|.|||:.:...|.|.||:||..||..||.:.|..|||
Mouse   592 ILGDLLKLGSSRPWREVLQEVTGESNISTKAFLTYFKPLMDWLVTENVKQGDTLGW 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	234/591 (40%)
Ace3	XP_006533116.1	Peptidase_M2	51..647	CDD:366618	240/608 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835941
Domainoid	1	1.000	533	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1397
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8699
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.800