Protein Alignment Acer and ACE

DIOPT Version :10

• Sequence 1: NP_477195.1
• Gene: Acer / 34189
• FlyBaseID: FBgn0016122
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 246/599 - (41%)
• Similarity: 348/599 - (58%)
• Gaps: 10/599 - (1%)

  Fly    17 LPHGLSMGNSCSASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNAEL 81
            ||.....|........||.:|.|..:...:..::|...:.:|||||:|....:.:::...:.|..
Human   632 LPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANH 696

  Fly    82 NKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSYTN 146
            ..:...|.:..|..|.::..|:|..:.:..|..:||.|.:.......:..|:|.|:.|||| :.|
Human   697 TLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HPN 760

  Fly   147 RSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSYAD 211
            .| | |.|||.:...::.||...:|.|.|..|.||:|..:.|.:.:||.|..:|::|||:....|
Human   761 GS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGD 823

  Fly   212 YWVQFYEDPDFERQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQSW 276
            .|...||.|..|:.|:..|::|.|.|..||.|||..|.:|||...:..||.||..||||||.|:|
Human   824 SWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTW 888

  Fly   277 NELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRP-DDR 340
            :.:.||..|:|..|.:|....|.|||:|.:::|:..|.||.|||:..:||.|||.|:|.:| |.|
Human   889 SNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGR 953

  Fly   341 HVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEAV 405
            .|||||||||||...|.|||.||.|:.....|.|||:|||||::||:..|...|...|||||||:
Human   954 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAI 1018

  Fly   406 GDVIALSVMSAKHLKAIGLIENGRLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNELDE 470
            |||:||||.:.|||.::.|:.:....::..||.|.|.||.||.|:||.|.||::|:.||...:.:
Human  1019 GDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITK 1083

  Fly   471 SQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRKAGQ 535
            ..:|..:|.:|.::.|:.|||.||:.||||.||:||.:.|.|:|||.:.|.|||||:|||:.||.
Human  1084 ENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH 1148

  Fly   536 YAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLYQW 600
            ..|      |..|||:.||.||:.|:..:..|.||.|.|.::..||:..|..:|:|.||:||..|
Human  1149 TGP------LHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDW 1207

  Fly   601 LKQENSRLGVPLGW 614
            |:.||...|..|||
Human  1208 LRTENELHGEKLGW 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_477195.1	Peptidase_M2	33..614	CDD:460196	241/581 (41%)
ACE	NP_000780.1	Peptidase_M2	40..623	CDD:460196
		Peptidase_M2	643..1221	CDD:460196	241/586 (41%)
		Juxtamembrane stalk. /evidence=ECO:0000269|PubMed:11274151	1215..1256		4/7 (57%)