Protein Alignment Acer and ACE

DIOPT Version :9

• Sequence 1: NP_001260258.1
• Gene: Acer / 34189
• FlyBaseID: FBgn0016122
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_000780.1
• Gene: ACE / 1636
• HGNCID: 2707
• Length: 1306
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 246/599 - (41%)
• Similarity: 348/599 - (58%)
• Gaps: 10/599 - (1%)

  Fly    17 LPHGLSMGNSCSASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVYARNAEL 81
            ||.....|........||.:|.|..:...:..::|...:.:|||||:|....:.:::...:.|..
Human   632 LPDNYPEGIDLVTDEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANH 696

  Fly    82 NKRLAQQIKSSDYVQSEDADIRRQAEHLSKLGASALNADDYLALQNAISSMQTNYATATVCSYTN 146
            ..:...|.:..|..|.::..|:|..:.:..|..:||.|.:.......:..|:|.|:.|||| :.|
Human   697 TLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVC-HPN 760

  Fly   147 RSDCSLTLEPHIQERLSHSRDPAELAWYWREWHDKSGTPMRQNFAEYVRLTRKASQLNGHRSYAD 211
            .| | |.|||.:...::.||...:|.|.|..|.||:|..:.|.:.:||.|..:|::|||:....|
Human   761 GS-C-LQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGD 823

  Fly   212 YWVQFYEDPDFERQLDATFKQLLPFYRQLHGYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQSW 276
            .|...||.|..|:.|:..|::|.|.|..||.|||..|.:|||...:..||.||..||||||.|:|
Human   824 SWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTW 888

  Fly   277 NELLDLFTPYPEKPFVDVKAEMEKQGYTVQKLFELGDQFFQSLGMRALPPSFWNLSVLTRP-DDR 340
            :.:.||..|:|..|.:|....|.|||:|.:::|:..|.||.|||:..:||.|||.|:|.:| |.|
Human   889 SNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGR 953

  Fly   341 HVVCHASAWDFYQDSDVRIKMCTEVDSHYFYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEAV 405
            .|||||||||||...|.|||.||.|:.....|.|||:|||||::||:..|...|...|||||||:
Human   954 EVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAI 1018

  Fly   406 GDVIALSVMSAKHLKAIGLIENGRLDEKSRINQLFKQALSKIVFLPFGYAVDKYRYAVFRNELDE 470
            |||:||||.:.|||.::.|:.:....::..||.|.|.||.||.|:||.|.||::|:.||...:.:
Human  1019 GDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITK 1083

  Fly   471 SQWNCGFWQMRSEFGGVEPPVFRTEKDFDPPAKYHIDADVEYLRYFAAHIFQFQFHKALCRKAGQ 535
            ..:|..:|.:|.::.|:.|||.||:.||||.||:||.:.|.|:|||.:.|.|||||:|||:.||.
Human  1084 ENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGH 1148

  Fly   536 YAPNNSRLTLDNCDIFGSKAAGRSLSQFLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLYQW 600
            ..|      |..|||:.||.||:.|:..:..|.||.|.|.::..||:..|..:|:|.||:||..|
Human  1149 TGP------LHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDW 1207

  Fly   601 LKQENSRLGVPLGW 614
            |:.||...|..|||
Human  1208 LRTENELHGEKLGW 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	235/568 (41%)
ACE	NP_000780.1	Peptidase M2 1	30..630
		Peptidase_M2	40..623	CDD:279709
		Peptidase M2 2	631..1232		246/599 (41%)
		Peptidase_M2	643..1221	CDD:279709	241/586 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	529	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm40361
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2384
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760