DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgp and FarO

DIOPT Version :9

Sequence 1:	NP_001260257.1	Gene:	Sgp / 34188	FlyBaseID:	FBgn0032055	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_652021.1	Gene:	FarO / 45707	FlyBaseID:	FBgn0023550	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	162/539 - (30%)
Similarity:	255/539 - (47%)	Gaps:	89/539 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QFYKDKSVFVTGGTGFLGKVIIEKLLRSTDVRRVYLLVRPKKNETVEGRFQAWKDEPVFKILLKA 71
            :|::|..:|||||:|.:||.::||||||.:|||:|:|:||:|..|.|.|....:...||.:|...
  Fly    11 EFFEDSEIFVTGGSGVVGKALVEKLLRSCNVRRIYVLLRPRKQLTAEQRLVRLRQATVFHVLAVQ 75

  Fly    72 KPEALKLVTPISGDCSEPGLGLSDGDRRMVTADVQVIIHSAASIRFVEPLQRALNINTRATRLMI 136
            |||.|..:..:.||.|.||||: |.........|.::.|.||::||.|||:.|:.:|...|...:
  Fly    76 KPEELDKIVAVPGDVSLPGLGI-DPSMMQRMKGVSLVYHCAATVRFDEPLREAVRLNVGGTLEAL 139

  Fly   137 QLAKEMKGLEAFVHISTAFSNCPSQHIEERFYPEHL---TCPAAKVLEFNETLSPD-LLDKMAPA 197
            :.|:.:..|.||:|:||.:||.....:|.::|...:   .|     |...:.::.| :|:.:...
  Fly   140 KFAETLPQLRAFIHVSTFYSNPYLTRVEPKYYSSPMDWRLC-----LRMIDDVADDGMLNALTRK 199

  Fly   198 LMGKFPNTYTYTKALAEQVIQMEGQDLPICVFRPAIILANFKEPMSGWIDNLHGVVALIYGNTYG 262
            |:..||||||:||.|||.::......||:.|:||:|:|...::|..|:..:|.|.:.|......|
  Fly   200 LIMGFPNTYTFTKNLAESLVNDYRHRLPVIVYRPSIVLFAVEDPSPGFSPSLMGAMGLFALVGAG 264

  Fly   263 ILRLLYVNPKADAIIVPGDYCANVALA---SGWQVAKNSESRSSSQLAAKKPP---PIYTLATTK 321
            ||:.:|:.......|.|.|......|.   .|:.:.:..            ||   |::.
  Fly   265 ILKTVYLGKDIRLDITPQDIGIKSMLCYTKMGYDIYRQG------------PPADLPVFL----- 312

  Fly   322 SNSITFGKAVKLGIHHNHT----------------IPVTKTIWYPFAHFTTCPWLFKLGCIFYHL 370
            |:|.|         |..||                :...|.:..|..|:|...|.::.......:
  Fly   313 SSSCT---------HVPHTFTQIAEQMDTLDLWRDVAFEKNLMIPGCHYTDKRWAYQFLVFTKQI 368

  Fly   371 IPGFFFDLLLRIQGKKPILMRSYQKIHEVLLLLFPFNGKTYEMDMNNTNQLWDSMSPEDR----- 430
            :|....||||||.|:||:||.:.:|.::.|.::.||.       .||    |||....|.
  Fly   369 LPALILDLLLRIFGQKPVLMSAVRKAYQTLEVMQPFM-------FNN----WDSPGVSDMETLSK 422

  Fly   431 ----SIFPFDMATLNWEEYF-------TRILSGMRVFLYKESWDTLEQAKKRLFRFYILHRSLQL 484
                |.|.||  ..|..:..       :.:|..:|..|.:|...|||::|:.|.....|:|.|:|
  Fly   423 HGEGSAFNFD--AFNHPDIHGLVIQSCSNMLHSIRTHLLREDPKTLERSKRILRIKVFLYRLLRL 485

  Fly   485 VLCLALGKIVWILYSVIAN 503
            .|...|  |:|:..|.:|:
  Fly   486 FLLYKL--ILWLWRSYLAH 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgp	NP_001260257.1	PLN02996	1..449	CDD:215538	143/483 (30%)
		FAR-N_SDR_e	12..333	CDD:187547	106/330 (32%)
		FAR_C	367..457	CDD:176924	29/105 (28%)
FarO	NP_652021.1	FAR-N_SDR_e	18..328	CDD:187547	109/341 (32%)
FarO	NP_652021.1	FAR_C	379..>410	CDD:296071	13/41 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466754
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26995
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.860